Construction and Aromatization of Hantzsch 1,4‐Dihydropyridines under Microwave Irradiation: A Green Approach

Abstract

Hantzsch reaction, leading to the synthesis of 1,4-dihydropyridines (1,4-DHPs) with momentous biological activities and pharmacological properties is a well-known MCR. In recent years, microwave irradiation (MWI) has been successfully used as the unconventional and green source of energy to promote organic transformations including Hantzsch 1,4-dihydropyri-dines. Literature survey disclosed that construction of 1,4-DHPs as well as their aromatization can be successfully performed under MWI in solution as well as in dry media. In this review, we try to underscore recent advances in the synthesis and aromatization of Hantzsch 1,4-DHPs under MWI as green approach.

Synthesis, Biological Evaluation, in silico ADMET and Molecular Docking of new 1,4‐Dihydropyridine Derivatives Bearing Ether Substitution as Calcium Channel Blockers

“…In this study, the synthesis of new 1,4‐dihydropyridine derivatives with methyl or ethyl esters in positions 3 and 5 and the substitution of different ethers in the C2 position of the dihydropyridine ring were performed ( 5 a – h ). In the first step, 1,4 dihydropyridine was synthesized using Hantzsch's synthesis [21] . As a result, symmetric 1,4‐dihydropyridines ( 2 a – b ) were prepared from thiophene‐2‐carbaldehyde and ammonium acetate and β‐Keto esters [22] .…”

“…In the first step, 1,4 dihydropyridine was synthesized using Hantzsch's synthesis. [21] As a result, symmetric 1,4-dihydropyridines (2 a-b) were prepared from thiophene-2-carbaldehyde and ammonium acetate and β-Keto esters. [22] In the next step, the monobromo derivatives (3 a-b) were synthesized using pyridinium bromideperbromide in the presence of pyridine in chloroform.…”

Synthesis of hydrazone-based polyhydroquinoline derivatives – antibacterial activities, α-glucosidase inhibitory capability, and DFT study

“… 3 Usually, the synthesis of PHQ derivatives involves the coupling of three or four components, such as dimedone, aldehyde, ethyl acetoacetate, and ammonia reflux in ethanol or acetic acid. 4 In drug discovery, the multi-component reaction plays a pivotal role. Therefore, for synthetic purposes, multi-component reactions are a more favored approach by younger researchers in academic and industrial realms.…”

Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs

“…For the generation of a diverse scaffold, other NIMCRs implemented are, namely, Pavarov-3CR, Dobener-3CR, Betti-3CR, and Petasis-3CR ( Figure 4 ). For further information on NIMCRs chemistry, the reader is directed toward comprehensive review articles and other very interesting recent publications [ 89 , 90 , 92 , 93 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 ].…”