Construction and application of CRISPR-mediated TBCK-Knockout system in multiple human and mouse cell models
JIN WU,
JIANJUN ZHU,
ANDREW DYNKA
et al.
Abstract:Background: Mutations in TBCK can generate truncated TBCK protein aggregates that abolish the normal function of the gene. Alterations in TBCK function have been implicated in developmental and neurogenetic disorders, as well as the progression of certain forms of cancer. Despite TBCK's involvement in various human diseases, the underlying mechanism for cancer pathogenesis remains poorly understood.
Methods: To further explore loss of function mutations in TBCK, we introduced a CRISPR-mediated … Show more
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