Construction and adaptation of an open source rapid prototyping machine for biomedical research purposes—a multinational collaborative development

Filho, Arnaldo Luís Lixandrão; Noritomi, Pedro Yoshito; Silva, J.V.L. da; Neto, Paulo Inforçatti; Cheung, P.Y.C.; Colangelo, N W; Kang, Hyun Jeong; Butcher, Jonathan T.; Lipson, Hod; Neto, Eliana

doi:10.1201/9780203859476-83

Cited by 3 publications

References 5 publications

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Laser microfabricated poly(glycerol sebacate) scaffolds for heart valve tissue engineering

Masoumi

Johnson

Zugates

et al. 2011

2011 IEEE 37th Annual Northeast Bioengineering Conference (NEBEC)

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Microfabricated poly(glycerol sebacate) (PGS) scaffolds may be applicable to tissue engineering heart valve leaflets by virtue of their controllable microstructure, stiffness, and elasticity. In the current study, PGS scaffolds were computationally designed and microfabricated by laser ablation to match the anisotropy and peak tangent moduli of native bovine aortic heart valve leaflets. Finite element simulations predicted PGS curing conditions, scaffold pore shape, and strut width capable of matching the scaffold effective stiffnesses to the leaflet peak tangent moduli. Based on simulation predicted effective stiffnesses of 1.041 MPa and 0.208 MPa for the scaffold preferred (PD) and orthogonal, cross-preferred (XD) material directions, scaffolds with diamond-shaped pores were microfabricated by laser ablation of PGS cured 12 hours at 160°C. Effective stiffnesses measured for the scaffold PD (0.83 ± 0.13 MPa) and XD (0.21 ± 0.03 MPa) were similar to both predicted values and peak tangent moduli measured for bovine aortic valve leaflets in the circumferential (1.00 ± 0.16 MPa) and radial (0.26 ± 0.03 MPa) directions. Scaffolds cultivated with fibroblasts for 3 weeks accumulated collagen (736 ± 193 μg/g wet weight) and DNA (17 ± 4 μg/g wet weight). This study provides a basis for the computational design of biomimetic microfabricated PGS scaffolds for tissue engineered heart valves.

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Laser microfabricated poly(glycerol sebacate) scaffolds for heart valve tissue engineering

Masoumi

Johnson

Zugates

et al. 2011

2011 IEEE 37th Annual Northeast Bioengineering Conference (NEBEC)

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Ascending in Space Dimensions: Digital Crafting of M.C. Escher's Graphic Art

Pasko

Vilbrandt³

et al. 2011

Leonardo

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M.C. Escher's artwork has inspired and arguably even informed computer science, as well as geometric and shape modeling. Even today, much of his work poses challenges to conventional digital shape modeling systems. The authors introduce several interesting problems presented by Escher's graphic artworks and describe their use of a novel approach, based on implicit surfaces and their extension (Function Representation), to produce 2D, 2.5D and 3D computer models. They also discuss several physical objects or sculptures based on these models, crafted using digital fabrication processes.

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