Constructing the cGAMP‐Aluminum Nanoparticles as a Vaccine Adjuvant‐Delivery System (VADS) for Developing the Efficient Pulmonary COVID‐19 Subunit Vaccines
Ning Wang,
Can Wang,
Chunliu Wei
et al.
Abstract:The cGAMP‐aluminum nanoparticles (CAN) are engineered as a vaccine adjuvant‐delivery system to carry mixed RBD (receptor‐binding domain) of the original severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its new variant for developing bivalent pulmonary coronavirus disease 2019 (COVID‐19) vaccines (biRBD‐CAN). High phosphophilicity/adsorptivity made intrapulmonary CAN instantly form the pulmonary ingredient‐coated CAN (piCAN) to possess biomimetic features enhancing biocompatibility. In vitro biR… Show more
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