Constructing multi-component organic/inorganic composite bacterial cellulose-gelatin/hydroxyapatite double-network scaffold platform for stem cell-mediated bone tissue engineering

Ran, Jiabing; Jiang, Pei; Liu, Shinian; Sun, Guanglin; Peng, Yan; Shen, Xinyu; Tong, Hua

doi:10.1016/j.msec.2017.04.062

Cited by 67 publications

(33 citation statements)

References 49 publications

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“…Besides all aforementioned usages, BNC is used (experimentally) as a scaffold in bone tissue engineering [121][122][123], cartilage regeneration [124], laryngeal medialization [125], as a patch for esophageal defect repair [126], and for closure of ventricular septal defects [127], among many others.…”

Section: In Vivo Scaffoldsmentioning

confidence: 99%

“…Biomedical sector -Further current developments in the BNC field mainly concern novel carrier materials for cell cultivation [122,137,138], encapsulation of cells/immobilization of enzymes [139], coating of medical devices [140], and the production of BNC materials using the well-known oxygen-transparent silicone supports [141,142]. In case of medical implants a lot of results is reported not only in the field of soft tissue implants (see Section In vivo scaffolds) but also regarding materials for bone regeneration [121,143,144].…”

Section: Recent Developments In Bnc Materialsmentioning

confidence: 99%

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Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

et al. 2018

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Nanocelluloses are natural materials with at least one dimension in the nano-scale. They combine important cellulose properties with the features of nanomaterials and open new horizons for materials science and its applications. The field of nanocellulose materials is subdivided into three domains: biotechnologically produced bacterial nanocellulose hydrogels, mechanically delaminated cellulose nanofibers, and hydrolytically extracted cellulose nanocrystals. This review article describes today's state regarding the production, structural details, physicochemical properties, and innovative applications of these nanocelluloses. Promising technical applications including gels/foams, thickeners/stabilizers as well as reinforcing agents have been proposed and research from last five years indicates new potential for groundbreaking innovations in the areas of cosmetic products, wound dressings, drug carriers, medical implants, tissue engineering, food and composites. The current state of worldwide commercialization and the challenge of reducing nanocellulose production costs are also discussed.

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Section: In Vivo Scaffoldsmentioning

confidence: 99%

Section: Recent Developments In Bnc Materialsmentioning

confidence: 99%

Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

et al. 2018

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“…9,46 By implanting the Alg-DA/QCHA gradient scaffold in rabbit femoral defect in vivo, the area of the defect was significantly reduced and a lot of the new bone tissues grew in the Alg-DA/QCHA gradient scaffolds group at 12 weeks after surgery, compared with the blank group and homogenous scaffold. The obtained gradient scaffolds showed high compression modulus, which were contributed to the existing of HA component and the stronger hydrogen bond and electrostatic interactions among the DA groups and the Alg and QCS chains.…”

Section: Discussionmentioning

confidence: 99%

“…This compression modulus was much higher than many CS based and other biopolymer-based scaffolds, which were reported to have only several KPa to hundred KPa, even with a high HA composition in their examples. 9,46 By implanting the Alg-DA/QCHA gradient scaffold in rabbit femoral defect in vivo, the area of the defect was significantly reduced and a lot of the new bone tissues grew in the Alg-DA/QCHA gradient scaffolds group at 12 weeks after surgery, compared with the blank group and homogenous scaffold. Moreover, the gradient scaffold was degraded after implanting into the animal body, which was satisfied with the growth of bone in the first degradation period.…”

Section: Discussionmentioning

confidence: 99%

Preparation and properties of dopamine‐modified alginate/chitosan–hydroxyapatite scaffolds with gradient structure for bone tissue engineering

Shi

Jiali

Zhang

et al. 2019

J Biomedical Materials Res

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Three‐dimensional (3D) homogenous scaffolds composed of natural biopolymers have been reported as superior candidates for bone tissue engineering. There are still remaining challenges in fabricating the functional scaffolds with gradient structures to similar with natural bone tissues, as well as high mechanical properties and excellent affinity to surround tissues. Herein, inspired by the natural bone structure, a gradient‐structural scaffold composed of functional biopolymers was designed to provide an optimized 3D environment for promoting cell growth. To increase the interactions among the scaffolds, dopamine (DA) was employed to modify alginate (Alg) and needle‐like nano‐hydroxyapatite (HA) was prepared with quaternized chitosan as template. The obtained dopamine‐modified alginate (Alg‐DA) and quaternized chitosan‐templated hydroxyapatite (QCHA) were then used to fabricate the porous gradient scaffold by “iterative layering” freeze‐drying technique with further crosslinking by calcium ions (Ca2+). The as‐prepared Alg‐DA/QCHA gradient scaffolds were possessed seamlessly integrated layer structures and high levels of porosity at around 77.5%. Moreover, the scaffolds showed higher compression modules (1.7 MPa) than many other biopolyermic scaffolds. The gradient scaffolds showed appropriate degradation rate to satisfy with the time of the bone regeneration. Both human chondrocytes and fibroblasts could adhesive and growth well on the scaffolds in vitro. Furthermore, an excellent osteogenetic activity of the gradient scaffold can effectively promote the regeneration of the bone tissue and accelerate the repair of the bone defects in vivo, compared with that of the scaffold with the homogenous structure. The novel multilayered scaffold with gradient structure provided an interesting option for bone tissue engineering. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1615–1627, 2019.

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“…Ran et al 116 prepared double-network hydrogels with BNC and gelatin by immersing the hydroxyapatite-coated BNC in a solution of gelatin at 45°C for 7 days (Fig. 10).…”

Section: Gelatinmentioning

confidence: 99%

Nanocellulose nanocomposite hydrogels: technological and environmental issues

et al. 2018

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Constructing multi-component organic/inorganic composite bacterial cellulose-gelatin/hydroxyapatite double-network scaffold platform for stem cell-mediated bone tissue engineering

Cited by 67 publications

References 49 publications

Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

Preparation and properties of dopamine‐modified alginate/chitosan–hydroxyapatite scaffolds with gradient structure for bone tissue engineering

Nanocellulose nanocomposite hydrogels: technological and environmental issues

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