Abstract:Ricin,
a protein found in castor seeds, is a lethal toxin
that is designated as a category 2 select agent, and cases of attempted
ricin poisoning are relatively common. Many methods to detect protein
toxins such as ricin use targeted liquid chromatography–tandem
mass spectrometry (LC–MS/MS) to identify toxin peptides, usually
tryptic peptides. The successful use of untargeted methods has also
been reported. However, the use of untargeted proteomics methods,
including database search, for peptide and protein id… Show more
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