Construct of MoSe2/Bi2Se3 nanoheterostructure: Multimodal CT/PT imaging-guided PTT/PDT/chemotherapy for cancer treating

Front. Bioeng. Biotechnol.

Yang

et al. 2019

106

Conventional chemotherapy for cancer treatment is usually compromised by shortcomings such as insufficient therapeutic outcome and undesired side effects. The past decade has witnessed the rapid development of combination therapy by integrating chemotherapy with hyperthermia for enhanced therapeutic efficacy. Near-infrared (NIR) light-mediated photothermal therapy, which has advantages such as great capacity of heat ablation and minimally invasive manner, has emerged as a powerful approach for cancer treatment. A variety of nanomaterials absorbing NIR light to generate heat have been developed to simultaneously act as carriers for chemotherapeutic drugs, contributing as heat trigger for drug release and/or inducing hyperthermia for synergistic effects. This review aims to summarize the recent development of advanced nanomaterials in chemo-photothermal combination therapy, including metal-, carbon-based nanomaterials and particularly organic nanomaterials. The potential challenges and perspectives for the future development of nanomaterials-based chemo-photothermal therapy were also discussed.

Section: Metal Nanomaterials-based Chemo-photothermal Therapymentioning

confidence: 99%

Recent Advances in Nanomaterials-Based Chemo-Photothermal Combination Therapy for Improving Cancer Treatment

Front. Bioeng. Biotechnol.

Yang

et al. 2019

106

“…Development of multifunctional nanoplatforms integrating both diagnostics and treatment functions for cancer nano-theranostics have attracted widespread research interest in nano-biotechnology [ 54 , 55 ]. However, it is still worth to construct theranostic nano-systems with multi-modal imaging to guide therapy.…”

Section: Resultsmentioning

confidence: 99%

Biodegradable hollow mesoporous organosilica nanotheranostics (HMON) for multi-mode imaging and mild photo-therapeutic-induced mitochondrial damage on gastric cancer

Guo

et al. 2020

J Nanobiotechnol

Background: CuS-modified hollow mesoporous organosilica nanoparticles (HMON@CuS) have been preferred as non-invasive treatment for cancer, as near infrared (NIR)-induced photo-thermal effect (PTT) and/or photo-dynamic effect (PDT) could increase cancer cells' apoptosis. However, the certain role of HMON@CuS-produced-PTT&PDT inducing gastric cancer (GC) cells' mitochondrial damage, remained unclear. Moreover, theranostic efficiency of HMON@CuS might be well improved by applying multi-modal imaging, which could offer an optimal therapeutic region and time window. Herein, new nanotheranostics agents were reported by Gd doped HMON decorated by CuS nanocrystals (called HMON@CuS/Gd). Results: HMON@CuS/Gd exhibited appropriate size distribution, good biocompatibility, l-Glutathione (GSH) responsive degradable properties, high photo-thermal conversion efficiency (82.4%) and a simultaneous reactive oxygen species (ROS) generation effect. Meanwhile, HMON@CuS/Gd could efficiently enter GC cells, induce combined mild PTT (43-45 °C) and PDT under mild NIR power density (0.8 W/cm 2). Surprisingly, it was found that PTT might not be the only factor of cell apoptosis, as ROS induced by PDT also seemed playing an essential role. The NIR-induced ROS could attack mitochondrial transmembrane potentials (MTPs), then promote mitochondrial reactive oxygen species

“…According to previous reports, the embedding of positive and negative ions can be reflected by the change in binding energy (BE) in graphite XPS spectrum. [31] In detail, embedded ions in the active material will generate a specific shift in the BE of a specific element of the electrode if the electron (de-)intercalation occurs. Specifically, the positive-going shift in the BE elucidates the increase in cation density, whereas the negative shift elucidates a raising density of electron.…”

Section: The Electrochemical Performance and The Application Of The Dimbmentioning

confidence: 99%

The First Flexible Dual‐Ion Microbattery Demonstrates Superior Capacity and Ultrahigh Energy Density: Small and Powerful

Liu

Zhang

et al. 2020

Adv Funct Materials

Humans live today in a high‐tech and informationalized society. With the development of the emerging electronic information age, various electronic systems are inclined to be multifunctional and miniaturized. It is urgent to develop “small and powerful” micro‐batteries with flexibility and high electrochemical performance to meet the diverse needs of microelectronic components. However, low electrochemical performance exists in traditional microenergy storage devices, which fail to satisfy the energy needs for microdevices. Here, for the first time, a planar integrated flexible rechargeable dual‐ion microbattery (DIMB) is reported, which is fabricated from an interdigital pattern of graphite as an electrode and lithium hexafluorophosphate as an electrolyte. As a microbattery, the DIMB exhibits a high reversible capacity of 56.50 mAh cm−3, and excellent cycle stability with 90% capacity retention after 300 cycles under a high working voltage. The application of DIMB in microdevices, such as light‐emitting diodes (LEDs), digital electronic game consoles, and electrochromic glasses is also investigated, fully demonstrating its “small and powerful” performance. The integrated DIMB is a high‐voltage microdevice that reaches a nonpareil discharge voltage of about 100 V and a charging capacity of 102 mAh g−1. This dual ion‐based flexible microbattery could become a promising candidate for energy storage and conversion components in next‐generation microelectronic devices and integrated electronic devices.