Constraint on boric acid resistance and tolerance evolvability inCandida albicans
Yana Syvolos,
Ola E. Salama,
Aleeza C. Gerstein
Abstract:Boric acid is a broad-spectrum antimicrobial used to treat vulvovaginal candidiasis when patients relapse on the primary azole drug fluconazole. Candida albicans is the most common cause of vulvovaginal candidiasis, colloquially referred to as a "vaginal yeast infection". Little is known about the propensity of C. albicans to develop BA resistance or tolerance (the ability of a subpopulation to grow slowly in high levels of drug). We evolved 96 replicates from eight genotypically diverse C. albicans strains to… Show more
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