Constraint-induced movement therapy alleviates motor impairment by inhibiting the accumulation of neutrophil extracellular traps in ischemic cortex

Li, Congqin; Hu, Jian; Xing, Ying; Zhang, Anjing; Zhang, Yuqian; Yan, Hua; Tian, Zhanzhuang; Bai, Yulong

doi:10.1016/j.nbd.2023.106064

Cited by 3 publications

(4 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…He communicated closely with Ce L and Hu J. This research has focused on areas such as ipsilateral corticospinal tracts (36), sensorymotor cortex and hippocampal synapses (37), phosphorylated extracellularly regulated protein kinase (38), AMPA receptordependent synapses in the ipsilateral hemisphere (39), and inhibition of extracellular traps of neutrophils in the ischemic cortex (40). In Taiwan, Lin KC from Natl Taiwan Univ, along with Wu CY and Chen CL, has concentrated on improving motor performance, daily functioning, and quality of life in chronic stroke patients through mCIMT, dCIMT, and constraint-induced therapy with trunk restraints (CIT-TR) in clinical randomized controlled studies (41)(42)(43).…”

Section: Discussionmentioning

confidence: 99%

“…The 261 journals that contained the 970 documents that were retrieved had the highest number of publications across the top three journals: Archives of Physical Medicine and Rehabilitation (63 articles with 1,275 total citations and 20.24 average citations), Neurorehabilitation and Neural Repair (78 articles with 1,392 total citations and an average of 17.85 citations), and Physical Therapy (33 articles with 411 total citations and 12.45 average citations). The top three journals in this field of research with high H-index and top three H-index are Archives of Physical Medicine and Rehabilitation (40), Neurorehabilitation and Neural Repair (37), and Stroke (25). There is a good amount of research in the relevant domains, as indicated by the Q1 and Q2 classifications assigned to all 10 journals.…”

Section: High-impact Journals Collaboration Analysismentioning

confidence: 99%

See 1 more Smart Citation

Global research hotspots and trends in constraint-induced movement therapy in rehabilitation over the past 30 years: a bibliometric and visualization study

Xu,

Chen,

Wang

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

BackgroundStroke is a cerebrovascular disease with high prevalence and mortality, and upper limb hemiparesis is a major factor limiting functional recovery in stroke patients. Improvement of motor function in stroke patients through various forms of constraint-induced movement therapy (CITM) has been recognized as safe and effective in recent years. This research field lacks a comprehensive systematic and clear vein combing analysis, analyzing the literature research of CIMT in the field of rehabilitation in the past three decades, summarizing the research hotspots and cutting-edge trends in this field, in an effort to offer ideas and references for subsequent researchers.MethodsRelevant literature on CIMT in rehabilitation was collected from 1996 to 2024 within the Web of Science database’s core dataset by using CiteSpace6.1, VOSviewer1.6.18, R-bibliometrix4.6.1, Pajek5.16, Scimago Graphica 1.0.26 software for visualization and analysis.ResultsThere were 970 papers in all United States was ranked first with 401 papers. Alabama Univ was ranked first for institutions with 53 papers. Neurorehabilitation and Neural Repair was ranked first for journals with 78 papers, and Taub E was ranked first for author publications with 64 papers. Research keywords were CIMT, stroke rehabilitation, upper extremity function, lower extremity gait balance, randomized controlled trials, physical therapy techniques (transcranial magnetic stimulation and sensory amplitude electrical stimulation), primary motor cortex plasticity, lateral dominance (spatial behaviors), cerebral vascular accidents, activities of daily living, hand function, disability, functional restoration, bimanual training, aphasia, acquired invalidity, type A Botulinum toxin and joystick riding toys.ConclusionThe current state of research shows that CIMT still has a vast potential for development in the field of rehabilitation research. The research hotspots are the clinical efficacy of CIMT combined with other therapies (botulinum toxin type A, transcranial direct current stimulation, virtual reality, mirror therapy, robotic-assisted) to enhance the functionality of upper limb hemiparesis in stroke patients, the mechanism of CIMT to improve the plasticity of the motor cortex through electrophysiological and imaging methods, and improvement of lower limb gait balance function in stroke patients and aphasia applications, the optimal intervention time and dose, and exploration of CIMT in new settings such as robot-assisted, telemedicine, and home rehabilitation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: High-impact Journals Collaboration Analysismentioning

confidence: 99%

Global research hotspots and trends in constraint-induced movement therapy in rehabilitation over the past 30 years: a bibliometric and visualization study

Xu,

Chen,

Wang

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…However, CIMT reduced the levels of NETs and the chemokines CCL2 and CCL5 in M1. Interestingly, CIMT did not further reduce neurological deficits after inhibiting NET formation via pharmacological inhibition of PAD4 [ 173 ].…”

Section: Nets: Treatment For Strokementioning

confidence: 99%

A promising frontier: targeting NETs for stroke treatment breakthroughs

Fang,

Bo,

Hao

et al. 2024

Cell Commun Signal

View full text Add to dashboard Cite

Stroke is a prevalent global acute cerebrovascular condition, with ischaemic stroke being the most frequently occurring type. After a stroke, neutrophils accumulate in the brain and subsequently generate and release neutrophil extracellular traps (NETs). The accumulation of NETs exacerbates the impairment of the blood‒brain barrier (BBB), hampers neovascularization, induces notable neurological deficits, worsens the prognosis of stroke patients, and can facilitate the occurrence of t-PA-induced cerebral haemorrhage subsequent to ischaemic stroke. Alternative approaches to pharmacological thrombolysis or endovascular thrombectomy are being explored, and targeting NETs is a promising treatment that warrants further investigation.

show abstract

“…Constraint-induced movement therapy (CIMT) is a rehabilitation therapy designed to improve upper limb motor function after stroke . In animal and clinical studies, CIMT is widely used to improve the affected limb function after stroke by forcing the use of the affected limb and restricting the use of the healthy side. , However, the mechanisms of CIMT are still unclear. It is necessary to explore the pathophysiological mechanism of rehabilitation therapy for a cerebral stroke.…”

Section: Introductionmentioning

confidence: 99%

Constraint-Induced Movement Therapy Modulates Neuron Recruitment and Neurotransmission Homeostasis of the Contralesional Cortex to Enhance Function Recovery after Ischemic Stroke

Zhang,

Xing,

Zheng

et al. 2024

ACS Omega

Self Cite

View full text Add to dashboard Cite

Stroke often results in long-term and severe limb dysfunction for a majority of patients, significantly limiting their activities and social participation. Constraint-induced movement therapy (CIMT) is a rehabilitation approach aimed explicitly at enhancing upper limb motor function following a stroke. However, the precise mechanism remains unknown. This study explores how CIMT may alleviate forelimb paralysis in ischemic mice, potentially through structural and functional remodeling of brain regions beyond the infarct area, especially the contralateral cortex. We demonstrated that CIMT recruits neurons from the contralesional cortex into the network that innervates the affected forelimb, as evidenced by PRV retrograde nerve tracing. Additionally, we investigated how CIMT influences synaptic plasticity in the contralateral cortex by evaluating synaptic growth marker levels and neurotransmission's homeostatic regulation. Our findings uncover a rehabilitative mechanism by which CIMT treats ischemic stroke, characterized by increased recruitment of neurons from the contralateral cortex into the network that innervates the affected forelimb, facilitated by homeostatic regulation of neurotransmission.

show abstract

Constraint-induced movement therapy alleviates motor impairment by inhibiting the accumulation of neutrophil extracellular traps in ischemic cortex

Cited by 3 publications

References 47 publications

Global research hotspots and trends in constraint-induced movement therapy in rehabilitation over the past 30 years: a bibliometric and visualization study

Global research hotspots and trends in constraint-induced movement therapy in rehabilitation over the past 30 years: a bibliometric and visualization study

A promising frontier: targeting NETs for stroke treatment breakthroughs

Constraint-Induced Movement Therapy Modulates Neuron Recruitment and Neurotransmission Homeostasis of the Contralesional Cortex to Enhance Function Recovery after Ischemic Stroke

Contact Info

Product

Resources

About