Constitutive relationship of tissue behavior with damage accumulation of human cortical bone

Luo, Qing; Leng, Huijie; Acuna, Rae L.; Dong, Xuesong; Rong, Qin; Wang, Xiaodu

doi:10.1016/j.jbiomech.2010.04.026

Cited by 12 publications

(16 citation statements)

References 33 publications

(49 reference statements)

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“…[1], [2], [3], [4] Several studies have reported microdamage in human trabecular bone occurring naturally. [5], [6], [7], [8], [9], [10] Increased microdamage is associated with decreased bone strength in vitro, and thus may play a role in fragility fractures.…”

Section: Introductionmentioning

confidence: 99%

Determinants of Microdamage in Elderly Human Vertebral Trabecular Bone

et al. 2013

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Previous studies have shown that microdamage accumulates in bone as a result of physiological loading and occurs naturally in human trabecular bone. The purpose of this study was to determine the factors associated with pre-existing microdamage in human vertebral trabecular bone, namely age, architecture, hardness, mineral and organic matrix. Trabecular bone cores were collected from human L2 vertebrae (n = 53) from donors 54–95 years of age (22 men and 30 women, 1 unknown) and previous cited parameters were evaluated. Collagen cross-link content (PYD, DPD, PEN and % of collagen) was measured on surrounding trabecular bone. We found that determinants of microdamage were mostly the age of donors, architecture, mineral characteristics and mature enzymatic cross-links. Moreover, linear microcracks were mostly associated with the bone matrix characteristics whereas diffuse damage was associated with architecture. We conclude that linear and diffuse types of microdamage seemed to have different determinants, with age being critical for both types.

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Section: Introductionmentioning

confidence: 99%

Determinants of Microdamage in Elderly Human Vertebral Trabecular Bone

et al. 2013

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“…When the damaged trabecular bone underwent creep loading, stress distribution within the bone will be rearranged, resulting in stress concentration and new fracture in undamaged trabeculae [32,33]. Evidence suggests that stress rearrangement depends on degree of bone damage [34]. Stress rearrangement in bone was negligible when modulus reduction was below 30%, but became significant if modulus reduction was greater than 30% [34].…”

Section: Explanation Of Resultsmentioning

confidence: 99%

Effects of bone damage on creep behaviours of human vertebral trabeculae

O’Callaghan

Szarko

Wang

et al. 2018

Bone

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A subgroup of patients suffering with vertebral fractures can develop progressive spinal deformities over time. The mechanism underlying such clinical observation, however, remains unknown. Previous studies suggested that creep deformation of the vertebral trabeculae may play a role. Using the acoustic emission (AE) technique, this study investigated effects of bone damage (modulus reduction) on creep behaviours of vertebral trabecular bone. Thirty-seven human vertebral trabeculae samples were randomly assigned into five groups (A to E). Bones underwent mechanical tests using similar experimental protocols but varied degree of bone damage was induced. Samples first underwent creep test (static compressive stress of 0.4MPa) for 30min, and then were loaded in compression to a specified strain level (0.4%, 1.0%, 1.5%, 2.5%, and 4% for group A to E, respectively) to induce different degrees of bone damage (0.4%, no damage control; 1.0%, yield strain; 1.5%, beyond yield strain, 2.5% and 4%, post-ultimate strains). Samples were creep loaded (0.4MPa) again for 30min. AE techniques were used to monitor bone damage. Bone damage increased significantly from group A to E (P<0.05), with >30% of modulus reduction in group D and E. Before compressive loading, creep deformation was not different among the five groups and AE hits in creep test were rare. After compressive loading, creep deformation was significantly greater in group D and E than those in other groups (P<0.05). The number of AE hits and other AE measurements during creep test were significantly greater in group D and E than in group A, B, and C (P<0.05 for all). Data suggested that with the increase of vertebral trabecular bone damage, substantial creep deformation may occur even when the vertebra was under physiological loads. The boosted creep deformation observed may be attributed to newly created trabecular microfractures. Findings provide a possible explanation as to why some vertebral fracture patients develop progressive spinal deformity over time.

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“…For this study, an intermediate value of 1.2 was selected. J 1 and ′ J 2 are strain invariants defined as (4) where ε − eq MAX is the highest equivalent strain encountered in the loading history. The form of the equation is similar to that used in a previous quasi-brittle damage model of bone.…”

Section: The Quasi-brittle Materials Modelmentioning

confidence: 99%

“…Osteoporotic hip fractures are an important source of morbidity and mortality, and understanding the mechanisms surrounding hip fracture may help to develop more effective preventative intervention strategies. Material level studies have demonstrated that the structural response of bone is history dependent . As bone material is loaded, it suffers progressive damage in the form of micro‐fractures .…”

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confidence: 99%

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Previous Damage Accumulation Can Influence Femoral Fracture Strength: A Finite Element Study

Haider

Frei

2019

Journal Orthopaedic Research

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To manage osteoporotic hip fracture risk, it is necessary to understand failure mechanisms of bone at both the material and organ level. The structural response of bone is dependent on load history. Repeated loading causes progressive microstructural cracking, resulting in reduced apparent‐level stiffness and, if damage is significant, reductions to peak load bearing capability. However, the effect of previous damage accumulation has not been well explored at the organ level. It was hypothesized that femoral fracture load and fracture pattern may be sensitive to damage accumulation from previous loading events. Six cadaveric specimens were used to develop patient specific finite element (FE) models from quantitative tomographic (qCT) scans. Material properties were assigned from qCT intensity at each element location, and damage evolution was predicted using a previously validated quasi‐brittle FE model. Three scenarios were investigated: stumble followed by another stumble (S‐S), fall followed by another fall (F‐F), and stumble followed by a fall (S‐F). Fracture load and pattern were compared to FE predictions for a single stumble (S) or single fall (F) loading event. Most specimens were resilient to accumulated damage, showing little (<5%) change in fracture load from the multiple‐load scenarios (S‐S, F‐F, and S‐F) compared to an equivalent single load scenario (S or F). Only one specimen demonstrated moderate (5–15%) reductions in strength from all three multiple‐load scenarios. However, two specimens experienced moderate (20–30%) increase in fracture load in some load cases. In these cases, initial damage caused the load to be more evenly distributed upon subsequent loading events. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2197–2203, 2019

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Constitutive relationship of tissue behavior with damage accumulation of human cortical bone

Cited by 12 publications

References 33 publications

Determinants of Microdamage in Elderly Human Vertebral Trabecular Bone

Determinants of Microdamage in Elderly Human Vertebral Trabecular Bone

Effects of bone damage on creep behaviours of human vertebral trabeculae

Previous Damage Accumulation Can Influence Femoral Fracture Strength: A Finite Element Study

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