Constitutive and induced cytokine production by human placenta and amniotic membrane at term

Paradowska, Edyta; Błach-Olszewska, Z; E, Gejdel

doi:10.1016/s0143-4004(97)80045-8

Cited by 75 publications

(46 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…IL-10 is produced by human placenta during gestation and the concentration decreases only at parturition (Paradowska et al, 1997;Simpson et al, 1998). IL-10 is also an important placental product in mice and anti-IL-10 can increase the fetal resorption rate in CBA ϫ DBA/2 matings (Chaouat et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Uterine lymphocyte distribution and interleukin expression during early pregnancy in cows

Leung¹,

Derecka²,

Mann³

et al. 2000

Reproduction

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Uterine lymphocyte distribution and interleukin expression during early pregnancy in cows

Leung¹,

Derecka²,

Mann³

et al. 2000

Reproduction

View full text Add to dashboard Cite

“…Interleukins 1 (IL-1), IL-6 and IL-10 can exhibit antiviral activity, at least in some cellular systems (Paradowska et al, 1997). CD40 and FAS ligands can inhibit viral replication by different pathways (McFadden, 1995).…”

Section: Resultsmentioning

confidence: 99%

“…In humans IFN-α was observed in the amniotic fluid and syncytiotrophoblast (Lebon et al, 1982;Howatson et al, 1988). In addition, in the first trimester of gestation, the presence of IFN-γ was verified (Paulesu et al, 1994). Duc-Goiran et al (1994) described the occurrence, in the rat, in fetal annexes (between day 10 to 21 of gestation) and in the fetus (from day 14 to birth) of a typical IFN-α.…”

Section: Introductionmentioning

confidence: 97%

Antiviral activity of bovine uterus and placenta induced by Newcastle disease virus

Filho¹,

Júnior²,

Golgher

et al. 2007

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

The antiviral activity profile of the uterus and fetal membranes from bovine placenta, induced by the Newcastle disease virus (NDV) throughout gestation, was investigated. Explants of the endometrium and caruncles were collected from the uterus, and amniochorion, allantochorion and cotyledons, from fetal placenta. Tissue cultures were induced with ~6.0 hemagglutinating units (HU) of NDV. Supernatants were concentrated 20 fold, filtered in 100kDa cut-off membranes and antiviral activity was titrated in MDBK x VSV system. Tissues of the uterus did not exhibit antiviral activity, while allantochorion and amniochorion produced antiviral factors throughout gestation. Antiviral factors were not related with IFN-α, γ, τ or TNF-α. The antiviral activity pattern observed showed to be related with the development of fetal membranes and increased at the end of pregnancy. Such data suggest that IFN genes inducible by virus are present in fetal membranes of the cow placenta and their expression is dependent on the age of gestation.Keywords: cattle, interferon, placenta RESUMO Investigou-se a atividade antiviral do útero e da placenta bovina, ao longo da gestação, induzidos pelo vírus da doença de Newcastle (NDV). Explantes do endométrio e carúnculas foram colhidos do útero. Os tecidos corioamniótico, corioalantóide e cotilédones foram dissecados da placenta fetal. Os cultivos celulares foram induzidos com aproximadamente 6,0 unidades hemaglutinantes do NDV. Os sobrenadantes foram concentrados 20 vezes, filtrados em dispositivos com superfície de separação de 100kDa e a atividade antiviral foi titulada em células MDBK e vírus da estomatite vesicular (VSV

show abstract

“…The expression of cytokines at the interface as early as the peri-implantation period seemed to be a confirmation [see above 115, 116, 117, 118, 119, 153, 154, 155, 156, 157, 158, 159, 160, 161]; Th2 chemokines were even described by Tsuda et al [159], as important in the phenomenon so that according to most reviews [160, 161, 162, 163, 164, 165], the Th1/Th2 seemed to reign supreme. It was often expressed in its (over)simplified form as done by Tom Wegmann for didactic reasons (but it was not , I can testify, having had discussions with him in Goa during the last days before his stroke, his ultimate thought!…”

Section: Reign Of the Th1/th2 Paradigmmentioning

confidence: 91%

“…Except for one study by Delassus et al [113], the very presence of the classical Th1 and especially Th2 cytokines – Th1 were already known – and of their receptors was traced at the interface in mice and humans and was demonstrated by a variety of techniques [ELISA, immunohistochemistry (IHC), in situ hybridization, PCR] and this was taken to be highly suggestive of autocrine-paracrine interactions [114, 115, 116, 117, 118], and a support for the paradigm.…”

Section: Reign Of the Th1/th2 Paradigmmentioning

confidence: 99%

Th1/Th2 Paradigm in Pregnancy: Paradigm Lost?

Chaouat

Lédée-Bataille

Dubanchet

et al. 2004

Int Arch Allergy Immunol

219

View full text Add to dashboard Cite

In this paper, we briefly survey the history of concepts in reproductive immunology from antibody-mediated tolerance to the ‘fetal allograft’ to the current concept of an embryo ‘bathing in a sea of cytokines’. We then review the paradigm that ‘allopregnancy is a Th2 phenomenon’ and some of the evidence gained in animals and humans supporting it. We continue by discussing the light it sheds on immunologically caused recurrent abortion, and the present status of the concepts. We next show the limits of the Th1/Th2 paradigm by reviewing the role of ‘inflammatory’ cytokines in implantation (as first seen with leukemia inhibitory factor). We go on to discuss recent data showing that interferon-γ is not solely a ‘bad guy’, e.g. abortifacient as the paradigm would predict, but is needed at low doses for the vascular development and transformation of uterine spiral arteries required for implantation and successful pregnancy. We conclude by discussing the emerging role of NK and IL-12, IL-15, IL-18 tripods and other cytokines in local angiogenesis and tissue remodelling, a series of new data bringing us well beyond the Th1/Th2 paradigm in pregnancy which, in this context, appears now obsolete and an oversimplification, although it has indeed been useful at first. Rather, step-specific events have to be considered and a key role is seen in local tissue remodelling, in which immune cytokines play an important role while not always being secreted by immune cells.

show abstract

Constitutive and induced cytokine production by human placenta and amniotic membrane at term

Cited by 75 publications

References 35 publications

Uterine lymphocyte distribution and interleukin expression during early pregnancy in cows

Uterine lymphocyte distribution and interleukin expression during early pregnancy in cows

Antiviral activity of bovine uterus and placenta induced by Newcastle disease virus

Th1/Th2 Paradigm in Pregnancy: Paradigm Lost?

Contact Info

Product

Resources

About