Constitutive activation of estrogen receptor α signaling in muscle prolongs exercise endurance in mice

Yoh, Kenta; Ikeda, Kazuhiro; Saki, Najmaldin; Horie, Kuniko; Takeda, Satoru; Inoue, Satoshi

doi:10.1016/j.bbrc.2022.08.064

Cited by 1 publication

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Section: Estrogen-er Signaling In the Regulation Of Skeletal Muscle F...mentioning

confidence: 99%

“…Our group generated Mck-caERα transgenic mice, which express a constitutively active mutant of human ERα (caERα) with a Y537S substitution in muscle [62,65,66]. The Mck-caERα transgenic mice muscle-specifically express caERα that exhibits ligandindependent transcriptional activation [62]. The Mck-caERα transgenic mice have no changed weights of skeletal muscles normalized to body weight, but prolonged running time in a treadmill exercise test, indicating that ERα activation in muscle elevated endurance capacity in mice.…”

Section: Estrogen-er Signaling In the Regulation Of Skeletal Muscle F...mentioning

confidence: 99%

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Roles of Estrogen, Estrogen Receptors, and Estrogen-Related Receptors in Skeletal Muscle: Regulation of Mitochondrial Function

Yoh

Ikeda

Horie

et al. 2023

IJMS

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Estrogen is an essential sex steroid hormone that functions primarily in female reproductive system, as well as in a variety of tissues and organs with pleiotropic effects, such as in cardiovascular, nervous, immune, and musculoskeletal systems. Women with low estrogen, as exemplified by those in postmenopause, are therefore prone to suffer from various disorders, i.e., cardiovascular disease, dementia, metabolic syndrome, osteoporosis, sarcopenia, frailty, and so on. Estrogen regulates the expression of its target genes by binding to its cognate receptors, estrogen receptors (ERs) α and β. Notably, the estrogen-related receptors (ERRs) α, β, and γ are originally identified as orphan receptors that share substantial structural homology and common transcriptional targets with ERs. Accumulating evidence suggests that ERs and ERRs play crucial roles in skeletal muscles, such as muscle mass maintenance, muscle exercise physiology, and muscle regeneration. In this article, we review potential regulatory roles of ERs and ERRs in muscle physiology, particularly with regard to mitochondrial function and metabolism.

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Section: Estrogen-er Signaling In the Regulation Of Skeletal Muscle F...mentioning

confidence: 99%

Section: Estrogen-er Signaling In the Regulation Of Skeletal Muscle F...mentioning

confidence: 99%

Roles of Estrogen, Estrogen Receptors, and Estrogen-Related Receptors in Skeletal Muscle: Regulation of Mitochondrial Function

Yoh

Ikeda

Horie

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

Constitutive activation of estrogen receptor α signaling in muscle prolongs exercise endurance in mice

Cited by 1 publication

References 40 publications

Roles of Estrogen, Estrogen Receptors, and Estrogen-Related Receptors in Skeletal Muscle: Regulation of Mitochondrial Function

Roles of Estrogen, Estrogen Receptors, and Estrogen-Related Receptors in Skeletal Muscle: Regulation of Mitochondrial Function

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