Constitutional pericentric inversion of chromosome 9 and haemopoietic stem cell transplantation: delayed engraftment

Imashuku, Shinsaku; Naya, Mayumi; An, Byongmun; Nakabayashi, Yoshinobu; Kuriyama, Kikuko; Udeda, Ikuyo; Morimoto, Akira; Hibi, Shigeyoshi; Todo, Shinjiro

doi:10.1046/j.1365-2141.2002.36618.x

Cited by 7 publications

(4 citation statements)

References 3 publications

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“…Previous case reports of delayed engraftment after autologous and allogeneic transplantation of inv(9) donors (Imashuku et al , 2002; Keung et al , 2002) suggest impaired engraftment potential of the inv(9) haematopoietic stem cells. The failure of recovery from pancytopenia induced by consolidation chemotherapy in this patient with inv(9), followed by uneventful engraftment after transplant from a normal donor further supports this hypothesis.…”

Section: Case Historymentioning

confidence: 90%

“…In response to our initial observation of delayed engraftment in two bone marrow transplantation patients from unrelated donors with constitutional inv(9) (Keung et al , 2002), Imashuku et al (2002) reported a case of autologous peripheral blood stem cell transplantation and delayed engraftment in a patient with acute myeloid leukaemia (AML) in second remission and constitutional inv(9). We describe another patient with AML and inv(9), similar to the case of Imashuku et al (2002), who subsequently underwent allogeneic bone marrow transplantation from a normal unrelated donor instead of autologous transplantation. In this case, there was no engraftment problem.…”

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confidence: 99%

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Constitutional pericentric inversion of chromosome 9 and bone marrow transplantation

Keung¹,

Knovich²,

Hurd³

et al. 2003

Br J Haematol

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Section: Case Historymentioning

confidence: 90%

mentioning

confidence: 99%

Constitutional pericentric inversion of chromosome 9 and bone marrow transplantation

Keung¹,

Knovich²,

Hurd³

et al. 2003

Br J Haematol

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“…Other studies reported little difference in the incidences of constitutional chromosome aberration between patients with hematologic malignancies and the general population; however, this may either be due to the low incidence of inv(9) [6][7][8] or the exclusion of inv(9) [9]. Although the association between inv(9) variation and CML is still a controversial topic, constitutional pericentric inv(9) may be important for predicting impaired engraftment potential of hematopoietic stem cells harboring inv(9) [10,11].…”

Section: Discussionmentioning

confidence: 99%

“…A careful review of literature and Mitelman database revealed that concomitant inv(9) and t(9;22) variations occurred sporadically in 8 patients [2,3,[12][13][14][15][16][17], which included 4 CML patients, 3 ALL patients, and 1 acute basophilic leukemia patient (Table 1) [7][8][9][10][11][12][13]. In this study,…”

Section: Discussionmentioning

confidence: 99%

Constitutional Pericentric Inversion 9 in Korean Patients with Chronic Myelogenous Leukemia

et al. 2010

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218Background : Although the pericentric inversion of chromosome 9, inv(9)(p11q13), is generally considered a normal variation, it is also associated with solid tumors and several hematologic malignancies such as biphenotypic acute leukemia, ALL, AML, and myeloproliferative neoplasms. However, to the best of our knowledge, there have been no reports that suggest an association between CML and constitutional pericentric inversion of chromosome 9. The purpose of this retrospective study was to investigate the frequency and clinical features of CML patients with concomitant inv(9) and t(9;22)(q34;q11.2) variation at our institution.Methods : We reviewed the bone marrow chromosome database entries between October 2006 and December 2008 to identify patients with concomitant inv(9) and t(9;22) variations. Laboratory and clinical data of the patients were obtained from the electronic medical record system.Results : Among the 51 CML patients, 4 (7.8%) had concomitant inv(9) and t(9;22) variations. Conclusions : Although the association between inv(9) variation and CML is still controversial, we believe that hematologists should consider the role of constitutional inv(9) variation in CML patients to avoid overlooking the impaired engraftment potential of hematopoietic stem cells harboring inv(9). Therefore, we suggest that more effort should be invested to develop cytogenetic tests for detecting constitutional inv(9) variation in CML patients. (Korean J Lab Med 2010;30:218-23)

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Constitutional pericentric inversion of chromosome 9 and hematopoietic recovery after allogeneic stem cell transplantation

et al. 2006

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Recent reports suggest that hemopoietic stem cells with constitutional pericentric inversion of chromosome 9 [inv(9)] may be related to delayed engraftment or hemopoietic defect after stem cell transplantation (SCT). We conducted a retrospective study on five allogeneic SCT in which constitutional inv(9) was detected either in the donor or the recipient. The results showed that hematologic recovery was within the expected time range for all our patients. However, one patient exhibited decreasing blood counts between day +45 and +272 after transplantation, possibly due to protracted cytomegalovirus (CMV) infection and gansiclovir and imatinib treatment. Our findings suggest that constitutional inv(9) may not be associated with delayed hemopoietic recovery after SCT.

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Constitutional pericentric inversion of chromosome 9 and haemopoietic stem cell transplantation: delayed engraftment

Cited by 7 publications

References 3 publications

Constitutional pericentric inversion of chromosome 9 and bone marrow transplantation

Constitutional pericentric inversion of chromosome 9 and bone marrow transplantation

Constitutional Pericentric Inversion 9 in Korean Patients with Chronic Myelogenous Leukemia

Constitutional pericentric inversion of chromosome 9 and hematopoietic recovery after allogeneic stem cell transplantation

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