Constitutional Delay of Growth and Adolescent Development

Bierich, J. R.

doi:10.1007/978-1-4684-5505-2_27

Cited by 5 publications

(6 citation statements)

References 43 publications

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Section: Discussionmentioning

confidence: 91%

“…In a study by Bierich (26) nighttime mean GH concentrations for children with constitutional growth delay were in the range of normal control subjects but were 53% of the control group. Bierich (26) suggested that boys with constitutional delay of growth may secrete relatively less GH than their normally maturing agemates. Whether the relative decrease in GH secretion is secondary to a pathologic process occurring in boys with constitutional delay of growth or is a reflection of their pubertal status and/or sex hormone milieu is as yet unknown.…”

Section: Discussionmentioning

confidence: 91%

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Nocturnal Serum Growth Hormone Concentration is not Augmented by Short-Term Testosterone Infusion in Pubertal Boys

et al. 1989

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ABSTRACT. Chronic exposure to testosterone (T) increases growth hormone (GH) secretion. To determine whether acute exposure to T would also enhance GH secretion, we infused saline, followed 1 wk later by T, for 18-24 h at one-third the adult male production rate in 12 pubertal boys and at the adult male production rate in eight additional pubertal boys. Blood was obtained every 20 min for GH and every 30 min for T from 2000-0800 h. Though infusion significantly increased serum T concentrations in all 20 boys, mean GH concentration, GH pulse frequency, and GH pulse amplitude did not increase compared to the saline infusion night. The secretory dynamics of GH as a function of 3-h time blocks from 2000-0800 h were also determined in the eight boys who received the higher dose of T. The profile for mean GH concentration, pulse frequency, pulse amplitude, and peak area were not affected by acute infusion of T at concentrations sufficient to alter LH secretion. This suggests that, at least in pubertal boys, one must be exposed to T for a period longer than 12-18 h to induce increased GH secretion. (Pediatr Res 26: 320-324,1989)

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 91%

Nocturnal Serum Growth Hormone Concentration is not Augmented by Short-Term Testosterone Infusion in Pubertal Boys

et al. 1989

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“…An important biochemical marker will be the IGF-1 (and possibly IGFBP-3) response to GH stimulation. 485,486 To some, it has consisted of delayed adolescent growth and maturation in the presence of decreased (even if only transiently) GH secretion. 483 Decreased serum concentrations of GHBP are obviously highly suggestive of a diagnosis of GHRD, but it is important to point out that cases of GHRD with normal serum concentrations of GHBP have already been identifi ed.…”

Section: -Treating For Growth Promotionmentioning

confidence: 99%

Disorders of Growth Hormone/Insulin-like Growth Factor Secretion and Action

Rosenfeld¹,

Cohen²

2008

Pediatric Endocrinology

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“…The two most common subgroups with these findings are genetic short stature, in which bone age is not delayed and the child is growing within the parental target range, and constitutional delay of growth, in which the child is short but bone age is delayed. 9,10 Intrinsic shortness is a familial (normal) variant. It also can occur with severe intrauterine growth retardation and in a large number of dysmorphic syndromes with genetic disorders.…”

Section: Variations In Normal Growthmentioning

confidence: 99%