Constitutional Aspects of the Osteochondroses

Duthie, Robert B.; Houghton, G. R.

doi:10.1097/00003086-198107000-00004

Cited by 54 publications

(21 citation statements)

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“…[33] In general, OC of the knee is considered to be most common, representing approximately 75% of all cases,[10] with manifestations in the elbow (second most commonly affected location), ankle, and hip occurring relatively uncommonly. [17] However, it is likely that any estimate of OC prevalence in humans is an underestimate, given that diagnosis is generally delayed until the onset of clinical signs[34]; many individuals may be asymptomatically affected and never diagnosed. In contrast, in horses, where survey radiographs are routinely taken in many breeds before the onset of clinical signs, global prevalence estimates range from 20% to 80%, although prevalence varies by joint and breed.…”

Section: Prevalence Of Osteochondrosismentioning

confidence: 99%

Articular osteochondrosis: a comparison of naturally-occurring human and animal disease

McCoy

Tóth

Dolvik

et al. 2013

Osteoarthritis and Cartilage

106

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Background Osteochondrosis (OC) is a common developmental orthopedic disease affecting both humans and animals. Despite increasing recognition of this disease among children and adolescents, its pathogenesis is incompletely understood because clinical signs are often not apparent until lesions have progressed to end-stage, and examination of cadaveric early lesions is not feasible. In contrast, both naturally-occurring and surgically-induced animal models of disease have been extensively studied, most notably in horses and swine, species in which OC is recognized to have profound health and economic implications. The potential for a translational model of human OC has not been recognized in the existing human literature. Objective The purpose of this review is to highlight the similarities in signalment, predilection sites and clinical presentation of naturally-occurring OC in humans and animals and to propose a common pathogenesis for this condition across species. Study Design Review Methods The published human and veterinary literature for the various manifestations of OC was reviewed. Peer-reviewed original scientific articles and species-specific review articles accessible in PubMed (US National Library of Medicine) were eligible for inclusion. Results A broad range of similarities exists between OC affecting humans and animals, including predilection sites, clinical presentation, radiographic/MRI changes, and histological appearance of the end stage lesion, suggesting a shared pathogenesis across species. Conclusion This proposed shared pathogenesis for OC between species implies that naturally-occurring and surgically-induced models of OC in animals may be useful in determining risk factors and for testing new diagnostic and therapeutic interventions that can be used in humans.

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Section: Prevalence Of Osteochondrosismentioning

confidence: 99%

Articular osteochondrosis: a comparison of naturally-occurring human and animal disease

McCoy

Tóth

Dolvik

et al. 2013

Osteoarthritis and Cartilage

106

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“…Others 6,9 believe that the disorder of the hip is part of a generalised condition, since children with Perthes' disease may be shorter than those in the normal population. 3 They may have hormonal abnormalities, 1,2 generalised abnormal radiological findings 9 and bilateral abnormality of the epiphyseal cartilage of the hip.…”

Section: Discussionmentioning

confidence: 99%

Perthes’ disease

Guerado

Garcés

2001

The Journal of Bone and Joint Surgery. British volume

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We studied 16 patients suffering from osteoarthritis of the hip who had had Perthes’ disease during childhood. They were compared clinically and radiologically with a control group who had not had Perthes’ disease, in order to assess whether a generalised, pre-existing constitutional disorder was present. Nine patients with a previous history of Perthes’ disease had some other skeletal abnormality, but only three presented with clinical symptoms. Only one patient in the control group was found to have an abnormality but was symptom-free. Our findings provide further evidence that patients with Perthes’ disease may have a generalised abnormality related to chondrogenesis which can produce other skeletal anomalies that persist into adult life.

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“…In view of these additional reports, it is interesting to note that the patient presented in this manuscript had a long history of steroid therapy. Increasingly, authors are suggesting that the pathogenesis of Freiberg's disease, like other osteochondroses, is likely multifactorial (4,9,10).…”

Section: Case Reportmentioning

confidence: 99%