Constituintes químicos das folhas e caule de Croton sellowii (Euphorbiaceae)

Júnior, Sebastião F. Palmeira; Alves, Vanessa L.; Moura, Fabyanne S.; Andrade-Vieira, Larissa Fonseca; Conserva, Lúcia M.; Lemos, Rosângela P. Lyra

doi:10.1590/s0102-695x2006000300018

Cited by 13 publications

(4 citation statements)

References 30 publications

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“…Many Croton species have shown pharmacological activities, such as anti-inflammatory [3,4], antinociceptive [5,6], anticancer [7] and, hypoglycemic [8,9]. This genus is well known chemically for the common presence of different types of diterpenes, such as clerodanes and kaurenes [10][11][12][13][14], flavonoids [15] and alkaloids [16][17][18].…”

mentioning

confidence: 99%

New 3,4-Seco Ent-Kaurenes from Croton Caracasana Flowers

Suárez

Chávez

Monachè³

et al. 2008

Natural Product Communications

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Two new 3,4-seco-ent-kaurenes, caracasine (1) and caracasine acid (2), were isolated from non-polar extracts of the flowers of Croton caracasana (Euphorbiaceae), together with six known terpenes, stigmasterol (4), stigmastenone (5), 2,6-dimethylocta-3,7-diene-2, 6-diol (6), spathulenol (7), caryophyllene oxide (8), and aromadendrene (9), and the flavonoid tribuloside (10). The chemical structures were determined by spectroscopic means and chemical correlations. All isolated compounds are being described for the first time for this species.

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confidence: 99%

New 3,4-Seco Ent-Kaurenes from Croton Caracasana Flowers

Suárez

Chávez

Monachè³

et al. 2008

Natural Product Communications

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“…Many species of Croton display anti-inflammatory, cytotoxic, antirheumatic, antiulcerogenic, antispasmodic, antidiabetic, anticholinesterasic, and analgesic activities, among others (Silva et al 2016a;Palmeira Júnior et al 2006). Antitumor activity has been found for essential oils from C. regelianus and C. flavens, as well as for some compounds isolated from C. flavens leaf oils (Sylvestre et al 2006;Bezerra et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Biological studies and chromatograms aided by chemometric analysis in evaluation of seasonality and extraction method of Croton grewioides extracts

et al. 2022

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The genus Croton is the second largest genus of Euphorbiaceae family, comprising more than 1300 registered species. The species Croton grewioides is endemic in the northeast of Brazil and distributed mainly throughout the caatinga biome presenting, in its essential oils, various compounds with biological activities such as pupicidal, larvicidal, insecticidal, and bactericidal. The secondary metabolites commonly found in their extracts include diterpenes, phenols, steroids, and aglycone and glycoside flavonoids derivatives, which can undergo variations based on climatic changes that modify processes such as photosynthesis, transpiration and nutrient cycle. To understand the effects of seasonal variability and extraction method on the biological activities of polar extracts from C. grewioides, fingerprint chromatograms were analyzed aided by chemometric analysis. In vitro assays of cytotoxicity against HL-60 and HepG2 cancer cells and anti-acetylcholinesterase activity were performed. Seasonal effects could only be observed in the chemical profiles of the methanolic and ethanolic extracts from accessions 113 and 126, respectively. Considering the extraction method, the chromatograms of aqueous and hydroalcoholic extracts of all the accessions were similar, but differed from those for the corresponding methanolic and ethanolic extracts. Five hexane partitions were active against HL-60 cell line, displaying inhibition values between 81 and 93%. Only the ethanolic extract of accession 101 (winter), the methanolic partition from the methanolic extract, and the decoction of accession 113 (winter) presented high inhibition values against the acetylcholinesterase enzyme. This study enabled elucidation of the effects of seasonality and extraction method on the biological activities presented by the C. grewioides extracts.

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“…1 Many species of Croton have strong economic potential, especially for the pharmaceutical industry, due to the various secondary metabolites that, according to many studies, are responsible for the therapeutic properties of them. 2 Pirani, a Brazilian botanist, has defined Croton as a "problem genus", mainly because of its large size and taxonomic complexity. 3 According to…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of 3,4-seco-Diterpenes Isolated from Croton blanchetianus against Streptococcus mutans and Streptococcus parasanguinis

Firmino¹,

Alexandre²,

Vasconcelos³

et al. 2017

J. Braz. Chem. Soc.

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In this study, acid and neutral fractions and three diterpenes were isolated from the hexane extracts from roots of three individual specimens of Croton blanchetianus Baill., collected from the same geographical site. Moreover, the antimicrobial activity of the extracts, fractions and diterpenes isolated was evaluated against Streptococcus mutans and Streptococcus parasanguinis, bacteria related with dental caries. The structures of the diterpenes were elucidated mainly by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, and high-resolution mass spectrometry, such as methyl 12-hydroxy-3,4-seco-cleistanta-8,11,13,15,4(18)-pentaene-3-oate; ent-3,4-secoatisa-4(18),16-dien-3-oic acid and a novel diterpene 3,4-seco-beieren-3-oic acid. Regarding to the antimicrobial activity, in general, all extracts, the neutral and acid fractions of the hexane extracts roots of all three specimens, showed antimicrobial activity in concentrations ranging from 500 to 7.8 µg mL -1 . In addition, the three diterpenes isolated showed bactericidal and bacteriostatic activity against S. mutans and S. parasanguinis, suggesting them as alternative agents with the potential to prevent oral diseases.

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Constituintes químicos das folhas e caule de Croton sellowii (Euphorbiaceae)

Cited by 13 publications

References 30 publications

New 3,4-Seco Ent-Kaurenes from Croton Caracasana Flowers

New 3,4-Seco Ent-Kaurenes from Croton Caracasana Flowers

Biological studies and chromatograms aided by chemometric analysis in evaluation of seasonality and extraction method of Croton grewioides extracts

Antimicrobial Activity of 3,4-seco-Diterpenes Isolated from Croton blanchetianus against Streptococcus mutans and Streptococcus parasanguinis

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