Constituents ofCrataegus pinnatifida var.psilosa leaves (II) —Flavonoids from BuOH fraction—

Oh, In Se; Whang, Wan Kyunn; Kim, Il Hyuk

doi:10.1007/bf02974168

Cited by 7 publications

(6 citation statements)

References 3 publications

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“…psilosa Schneid. by nuclear magnetic resonance (NMR) 15. A compound of the same molecular weight was found in fruits of C. pinnatifida var.…”

Section: Phenolic Compounds In Hawthorn Of Different Originsmentioning

confidence: 80%

“…3). 14, 15, 17 Vitexin and vitexin‐2″‐ O ‐rhamnoside were identified in flowering tops of C. laevigata, Crataegus rhipidopylla Gand. and their hybrid Crataegus × macrocarpa Hegetschw.…”

Section: Phenolic Compounds In Hawthorn Of Different Originsmentioning

confidence: 99%

“…by thin layer chromatography (TLC) and HPLC 17. Oh et al 15 reported vitexin‐2″‐rhamnoside in leaves of C. pinnatifida var. psilosa .…”

Section: Phenolic Compounds In Hawthorn Of Different Originsmentioning

confidence: 99%

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Composition and health effects of phenolic compounds in hawthorn (Crataegus spp.) of different origins

Yang¹,

Liu²

2012

J Sci Food Agric

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Epicatechin, aglycons and glycosides of B-type oligomeric procyanidins and flavonols, phenolic acids and C-glycosyl flavones are the major groups of phenolic compounds in hawthorn (Crataegus spp). The total content of phenolic compounds is higher in the leaves and flowers than in the fruits. Procyanidins dominate in the fruits, whereas flavonol glycosides and C-glycosyl flavones are most abundant in the leaves. Genotype and developmental/ripening stage have strong impacts. Procyanidin glycosides and C-glycosyl flavones may be chemotaxonomic markers differentiating species and varieties of hawthorn. Future research shall improve the separation, identification and quantification of procyanidins with degree of polymerisation (DP) ≥ 6, procyanidin glycosides, C-glycosyl flavones and some flavonol glycosides. In vitro and animal studies have shown cardioprotective, hypolipidaemic, hypotensive, antioxidant, radical-scavenging and anti-inflammatory potentials of hawthorn extracts, suggesting different phenolic compounds as the major bioactive components. However, the varying and insufficiently defined composition of the extracts investigated, as a result of different raw materials and extraction methods, makes comparison of the studies very difficult. Clinical evidence indicates that some hawthorn extracts may increase the exercise tolerance of patients with congestive heart failure. More clinical studies are needed to establish the effects of hawthorn, especially in healthy humans.

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“…psilosa Schneid. by nuclear magnetic resonance (NMR) 15. A compound of the same molecular weight was found in fruits of C. pinnatifida var.…”

Section: Phenolic Compounds In Hawthorn Of Different Originsmentioning

confidence: 80%

Section: Phenolic Compounds In Hawthorn Of Different Originsmentioning

confidence: 99%

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Composition and health effects of phenolic compounds in hawthorn (Crataegus spp.) of different origins

Yang¹,

Liu²

2012

J Sci Food Agric

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“…These data suggested that compound 1 comprised a flavan skeleton with a 3,5,7,3′,4′,5′-hexasubstitution pattern, and was identified as (−)-epigallocatechin 3- O -( E )- p -coumaroate, based on its NMR data and rotation data,

: −204.5 (MeOH) [ 22 ]. The other flavonoids were also determined based on their NMR and ESI-MS data, as (−)-epigallocatechin 3- O -( Z )- p -coumaroate (flavonoid 2) [ 23 ], (−)-gallocatechin (flavonoid 3) [ 24 ], (+)-catechin (flavonoid 4) [ 22 ], (−)-epigallocatechin (flavonoid 5) [ 25 ], (−)-epicatechin (flavonoid 6) [ 22 ], dihydroquercetin (flavonoid 7) [ 26 ], (+)-dihydrokaempferol (flavonoid 8) [ 27 ], quercetin (flavonoid 9) [ 28 ], rutin (flavonoid 10) [ 29 ], and quercetin-3- O - α - l -rhamnopyranosyl-(1→6)- β - d -galactopyranoside (flavonoid 11) [ 30 ], respectively (see Supporting Information ). All of the flavonoids 1–11 were isolated from P. pulchellum for the first time, and flavonoids 1 , 2 , 8 , and 1 1 were obtained from the genus Phyllodium initially.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Composition, Hepatoprotective, and Antioxidant Activities of Phyllodium pulchellum (L.) Desv

et al. 2018

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Phyllodiumpulchellum has been traditionally used as a medicinal herb because of its health-promoting effects, such as its hepatoprotective and antioxidant activities. In the present study, the petroleum ether fraction, ethyl acetate fraction, n-butanol fraction, and aqueous fraction were successively obtained from the ethanol extract of P. pulchellum. Two fractions, ethyl acetate fraction and n-butanol fraction, were found to display hepatoprotective and antioxidant activities. Further chemical investigation of the active fractions led to the isolation of its main constituents, including 11 flavonoids (1–11) and 8 indole alkaloids (12–19). There were 9 flavonoids (1–9) that were obtained from the ethyl acetate fraction, and 2 flavonoids (10 and 11) and 8 alkaloids (12–19) from the n-butanol fraction. Compounds 1–11 and 16–19 were isolated for the first time from P. pulchellum, and 1, 2, 8, 11, and 18 were obtained from the genus Phyllodium initially. Subsequently, the isolated compounds were evaluated for their in vitro hepatoprotective effects on the human normal hepatocyte cell line L-O2 injured by d-galactosamine and radical scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH). The flavonoids (−)-epigallocatechin (5) and (−)-epicatechin (6) exhibited prominent hepatoprotective activities with higher cell viability values (65.53% and 62.40% at 10 μM·mL−1, respectively) than the positive control, silymarin (61.85% at 10 μM·mL−1). In addition, compared with the positive control of vitamin C (IC50: 5.14 μg·mL−1), (−)-gallocatechin (3) and (−)-epigallocatechin (5) exhibited stronger antioxidant activities with IC50 values of 3.80 and 3.97 μg·mL−1, respectively. Furthermore, the total flavonoids from P. pulchellum were characterized using a high-performance liquid chromatography-linear ion trap quadrupole-Orbitrap-mass spectrometry (HPLC-LTQ-Orbitrap-MS). In total, 34 flavonoids were tentatively identified, which had not been previously reported from P. pulchellum. In addition, we performed a semi-quantitative analysis of the isolated flavonoids. The contents of compounds 1–11 were 3.88, 17.73, 140.35, 41.93, 27.80, 4.34, 0.01, 0.20, 9.67, 795.85, and 5.23 μg·g−1, respectively. In conclusion, this study revealed that the flavonoids that were isolated from P. pulchellum showed hepatoprotective and antioxidant activities, indicating that, besides alkaloids, the flavonoids should be the potential pharmacodynamic ingredients that are responsible for the hepatoprotective and antioxidant activities of P. pulchellum.

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“…To the best of our knowledge, this is the first time that the two compounds have been isolated from microorganisms. [19][20][21]. Compound 2 was readily soluble in water, slightly soluble in ethanol, and hardly soluble in chloroform.…”

mentioning

confidence: 99%

Two Compounds from the Endophytic Colletotrichum sp. of Ginkgo biloba

Zhou

Wang

et al. 2011

Natural Product Communications

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Two compounds, apigenin-8-C-β-D-glucopyranoside and 2-(hydroxymethylthio)ethanol, were extracted from the fermentation products of a strain of endophytic fungus, Colletotrichum sp. NTB-2, isolated from the leafstalk of Ginkgo biloba. The structures of the two compounds were determined on the basis of extensive spectroscopic analysis, including 1D and 2D NMR spectral data. The compounds were obtained from microorganisms for the first time.

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Constituents ofCrataegus pinnatifida var.psilosa leaves (II) —Flavonoids from BuOH fraction—

Cited by 7 publications

References 3 publications

Composition and health effects of phenolic compounds in hawthorn (Crataegus spp.) of different origins

Composition and health effects of phenolic compounds in hawthorn (Crataegus spp.) of different origins

Phytochemical Composition, Hepatoprotective, and Antioxidant Activities of Phyllodium pulchellum (L.) Desv

Two Compounds from the Endophytic Colletotrichum sp. of Ginkgo biloba

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