Constituents of the Leaf and Flower Oils of<i>Agastache rugosa</i>(Fisch. et Mey) O. Kuntze from Vietnam

Dũng, Nguyên Xuân; Cu, Lu'u Dam; Thai, N.H.; Moi, La Dinh; Hac, Le Van; Leclercq, P.A.

doi:10.1080/10412905.1996.9700580

Cited by 16 publications

(11 citation statements)

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“…Generally, the volatile compounds produced from inflorescences are two to six times more volatile per gram than those found in the leaves. Our results were similar to those reported by (Vlietinck & Kubelka 2004) [ 22 ] (1996) for the essential oils found in the leaves and flowers of A. rugosa in Vietnam [ 23 ]. They also found that the essential oil in the leaves and flowers was characterised by a high amount of estragole; however, they reported greater amounts in the leaves than in the flowers, whereas in the current study, less estragole was extracted from the leaves by HS–SPME than from the flower spikes and flower with nectar.…”

Section: Resultssupporting

confidence: 92%

Analysis of the volatile organic compounds from leaves, flower spikes, and nectar of Australian grown Agastache rugosa

Yamani

Mantri

Morrison

et al. 2014

BMC Complement Altern Med

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BackgroundThe foraging choices of honey bees are influenced by many factors, such as floral aroma. The composition of volatile compounds influences the bioactivity of the aromatic plants and honey produced from them. In this study, Agastache rugosa was evaluated as part of a project to select the most promising medicinal plant species for production of bioactive honey.MethodsHeadspace solid-phase microextraction HS-SPME /GC-MS was optimized to identify the volatile bioactive compounds in the leaves, flower spikes, and for the first time, the flower nectar of Australian grown A. rugosa.ResultsMethyl chavicol (= estragole) was the predominant headspace volatile compound in the flowers with nectar, flower spikes, and leaves, with a total of 97.16%, 96.74% and 94.35%, respectively. Current results indicate that HS–SPME/GC–MS could be a useful tool for screening estragole concentration in herbal products.ConclusionRecently, estragole was suspected to be carcinogenic and genotoxic, according to the European Union Committee on Herbal Medicinal Products. Further studies are needed on safe daily intake of Agastache as herbal tea or honey, as well as for topical uses.

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Section: Resultssupporting

confidence: 92%

Analysis of the volatile organic compounds from leaves, flower spikes, and nectar of Australian grown Agastache rugosa

Yamani

Mantri

Morrison

et al. 2014

BMC Complement Altern Med

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“…Determination of volatile constituents: Essential oil hydrodistillation using Clevenger apparatus or pharmacopoeia distillation apparatus (Charles et al 1991 ; Mazza and Kiehn 1992 ; Svoboda et al 1995 ; Dung et al 1996 ; Tirillini et al 1997 ; Dapkevicius et al 1998 ; Kim et al 2001a ; Maruyama et al 2002 ; Shin and Kang 2003 ; Omidbaigi and Sefidkon 2003 , 2004 ; Estrada-Reyes et al 2004 ; Mallavarapu et al 2004 ; Shin and Pyun 2004 ; Bruni et al 2007 ; Omidbaigi et al 2008 ; Tian et al 2009 ; Ebadollahi et al 2010 , 2011; Omidbaigi and Mahmoodi 2010 ; Skakovskii et al 2010 ; Gong et al 2012a , b ; Li et al 2013 ); Essential oil distillation–extraction (Wang 2010 ); Extraction with organic solvents: hexane, hexane–EtOAc mixtures, EtOAc, EtOAc–MeOH mixtures, MeOH, dichloromethane (Kim et al 2001b ; Shin et al 2001 ; Estrada-Reyes et al 2004 ); Extraction with diethyl ether and boiling methanol followed by cold storage (−20 °C) and steam distillation (Weyerstahl et al 1992 ); Headspace (Mazza and Kiehn 1992 ; Wilson et al 1992 ; Zielinska et al 2011 ); Glass microneedles used for the determination of secretory trichomes constituents (Tirillini et al 1997 ). …”

Section: Phytochemistrymentioning

confidence: 99%

Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

2014

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Agastache is a small genus of Lamiaceae, comprising 22 species of perennial aromatic medicinal herbs. In this article, we review recent advances in phytochemical, pharmacological, biotechnological and molecular research on Agastache. The phytochemical profile of all Agastache species studied to date is generally similar, consisted of two main metabolic classes—phenylpropanoids and terpenoids. In the relatively variable essential oils, most populations of different Agastache species contain over 50 % of a phenylallyl compound—estragole. Also, other volatile compounds (methyleugenol, pulegone, menthone, isomenthone and spathulenol) were reported in various proportions. Major non-volatile metabolites belong to phenolic compounds, such as caffeic acid derivatives, especially rosmarinic acid as well as several flavones and flavone glycosides like acacetin, tilianin, agastachoside, and a rare dimeric malonyl flavone (agastachin). Two unique lignans—agastenol and agastinol—were also isolated. Terpenoids include triterpenoids of oleanane-type (maslinic acid, oleanolic acid and β-amyrin), ursane-type (ursolic acid, corosolic acid and α-amyrin), and typical plant sterols, as well as abietane-type oxidized diterpenes (e.g., agastaquinone, agastol, and others). The bioactivity of various extracts or individual compounds in vitro and in vivo include antimicrobial, antiviral and anti-mutagenic activity, cytotoxic activity to cancer cell lines, and anti-nociceptive, anti-inflammatory, anti-atherogenic, antioxidant as well as biocidal activity to several foodstuff pests. Biotechnological and molecular studies have focused on in vitro propagation and enhancing the biosynthesis of bioactive metabolites in cell or organ cultures, as well as on the expression of genes involved in phenolic biosynthesis.

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“…Meyer) O. Kuntze (Lamiaceae) (also known as giant hyssop or Korean mint) is widely distributed throughout East Asia and is used locally as a herbal drug and spice. It has antibacterial and antifungal activity (Shin 2004;Song et al 2001) and is used against fever, headache, stomach pain and other gastrointestinal disorders (Dung et al 1996).…”

Section: Introductionmentioning

confidence: 98%

“…Essential oil and headspace volatile organic compounds (HS-VOCs) of A. rugosa usually contain estragole (methyl chavicol) as a major compound (Dung et al 1996;Song et al 2001;Wilson et al 1992). Chae et al (2005) grouped Korean A. rugosa plants into five chemotypes, namely, estragole, menthone, menthone plus pulegone, methyleugenol, and methyleugenol plus limonene.…”

Section: Introductionmentioning

confidence: 99%

Influence of plant growth regulators on volatiles produced by in vitro grown shoots of Agastache rugosa (Fischer & C.A.Meyer) O. Kuntze

Zielińska

Piątczak

Kalemba

et al. 2011

Plant Cell Tiss Organ Cult

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The composition of volatile organic compounds emitted by in vitro shoots of Agastache rugosa (Fischer & C.A. Meyer) O. Kuntze (Lamiaceae) was studied using headspace solid-phase microextraction-gas chromatography-mass spectrometry and compared to the those emitted by adult plants and in vitro-germinated seedlings. Shoot-tip explants were cultured on a solid MS medium supplemented with either 4.4 lM 6-benzyladenine (BA), 9.3 lM kinetin, or 0.45 lM thidiazuron and with either 0.57 lM indole-3-acetic acid (IAA) or 0.41 lM picloram. Shoot proliferation was observed in all these treatments. The presence of these plant growth regulators in the culture medium significantly influenced the composition of volatiles as well as morphogenetic responses observed. The number and quality of regenerating shoots and frequency of axillary bud break were highest in medium containing the BA ? IAA combination. Sixty-five compounds were identified in the headspace of the in vitroproduced material and plants cultivated in the field. The in vitro shoots emitted both hydrocarbon (limonene, a-pinene) and oxidized (menthone, isomenthone, pulegone) monoterpenes. The composition of monoterpenes differed depending on the type of auxin-rather than cytokinin-in the medium. The emission of phenylallyl compounds, such as estragole, a major compound in field-grown plants, was markedly lower in shoot cultures.

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Constituents of the Leaf and Flower Oils ofAgastache rugosa(Fisch. et Mey) O. Kuntze from Vietnam

Cited by 16 publications

References 10 publications

Analysis of the volatile organic compounds from leaves, flower spikes, and nectar of Australian grown Agastache rugosa

Analysis of the volatile organic compounds from leaves, flower spikes, and nectar of Australian grown Agastache rugosa

Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

Influence of plant growth regulators on volatiles produced by in vitro grown shoots of Agastache rugosa (Fischer & C.A.Meyer) O. Kuntze

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