Constituents of Stem Bark of Callistemon rigidus Showing Inhibitory Effects on Mouse .ALPHA.-Amylase Activity

Kobayashi, Kyoko; Ishihara, Tamaki; Khono, Eriko; Miyase, Toshio; Yoshizaki, Fumihiko

doi:10.1248/bpb.29.1275

Cited by 34 publications

(28 citation statements)

References 14 publications

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“…Consistent with these reports, our results indicated that the inhibitory effects of scirpusin B (4) against a-glucosidase were stronger than those of the less hydroxylated derivative, scirpusin A. The a-glucosidase inhibition may contribute to the blood glucose-lowering effect of scirpusin B in the glycogen-loaded mouse model reported previously by Kobayashi et al (2006). Although the a-amylase inhibitory activity of the aerial parts of C. rotundus has been reported (Sayed et al, 2008), this is the first study of the effects of C. rotundus rhizomes on a-amylase and a-glucosidase activities.…”

Section: Resultssupporting

confidence: 92%

Inhibitors ofα-glucosidase andα-amylase fromCyperus rotundus

Tran

Nguyen

et al. 2013

Pharmaceutical Biology

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Context: A methanol extract of Cyperus rotundus L. (Cyperaceae) rhizomes showed inhibitory activity against a-glucosidase and a-amylase, two enzymes involve in carbohydrate digestion. Objective: Identification of compounds from C. rotundus rhizomes responsible for the inhibition of a-glucosidase and a-amylase. Materials and methods: Compounds were identified by a phytochemical investigation using combined chromatographic and spectroscopic methods. a-glucosidase and a-amylase inhibitory activities were evaluated by in vitro enzyme inhibition assays.0 ,5,6,7,8-hexahydroxyflavane (1), together with three known stilbene dimers cassigarol E (2), scirpusin A (3) and B (4) were isolated. Compound 2 inhibited both a-glucosidase and a-amylase activities while the flavane 1 only showed effect on a-amylase, and compounds 3 and 4 were active on a-glucosidase. All four compounds showed significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. Discussion: The inhibitory activities against a-amylase and a-glucosidase of the C. rotundus rhizomes were reported for the first time. Stilbene dimers are considered as potent inhibitors of a-glucosidase and promising antihyperglycemic agents. Conclusion: The isolated compounds may contribute to the antidiabetic property of C. rotundus.

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Section: Resultssupporting

confidence: 92%

Inhibitors ofα-glucosidase andα-amylase fromCyperus rotundus

Tran

Nguyen

et al. 2013

Pharmaceutical Biology

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“…Scirpusin B is reported to repress increases in blood glucose after oral administration of glycogen through inhibition of α-amlylase. 25) Inhibition of α-glucosidase is a major mechanism of reducing blood glucose by foods. Isorhapontigenin and scirpusin B may contribute the antidiabetic effect of PFSE.…”

Section: Discussionmentioning

confidence: 99%

Piceatannol Lowers the Blood Glucose Level in Diabetic Mice

Uchida-Maruki

Inagaki

Ito

et al. 2015

Biological & Pharmaceutical Bulletin

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We previously found that passion fruit (Passiflora edulis) seeds contained a high amount of piceatannol (3,5,3′,4′-trans-tetrahydroxystilbene), a natural analog of resveratrol (3,5,4′-trans-trihydroxystilbene). Resveratrol has been proposed as a potential anti-metabolic disorder compound, by its activation of sirtuin and AMP-activated protein kinase. Many reports show that resveratrol ameliorates diet-induced obesity and insulin resistance. However, it is not known whether piceatannol also affects diet-induced obesity. We explored the effect of piceatannol on high fat diet-fed mice. The results showed that piceatannol did not affect high fat diet-induced body weight gain or visceral fat gain in mice. However, piceatannol did reduce fasting blood glucose levels. Furthermore, to explore the potential of passion fruit seed extract containing piceatannol as a functional food, passion fruit seed extract was administered in a genetic diabetic mouse model (db/db mice). Single administration of passion fruit seed extract, as well as piceatannol reduced the blood glucose levels of these db/db mice. These results suggest that piceatannol and passion fruit seed extract may have potential application in the prevention of diabetes.Key words piceatannol; passion fruit seed; antidiabetic activity; high fat diet; db/dbThe incidence of metabolic syndrome is increasing worldwide due to aging and changes in lifestyle. In particular, this increase is largely attributed to the rise in the prevalence of obesity, and this common metabolic disorder is associated with increased risk of cardiovascular diseases and type II diabetes, and the latter substantially decreases quality of life and increases health care costs. It is difficult to strictly control blood glucose levels over the long term, even though many anti-diabetic medications are clinically available. Therefore, the development of functional foods that can prevent or improve type II diabetes is an urgent matter.Resveratrol is a natural component of several plants, including grapes, berries, and peanuts. Resveratrol displays widespread functions and has several health-promoting effects owing to its anti-cancer, anti-inflammation, and antioxidant activity.1) Recently, resveratrol has been proposed as a potential anti-metabolic syndrome compound because of its role in activating sirtuin and AMP-activated protein kinase (AMPK).2-5) Indeed, several studies have shown that resveratrol protects mice against diet-induced obesity.6-8) Resveratrol has also been shown to have a favorable effect on glucose metabolism in humans.9,10) However, it should be noted that no weight loss has been reported after resveratrol treatment in any human study. 11)Piceatannol is a hydroxylated analog of resveratrol and is also found in various plants, including grapes and rhubarb. Although piceatannol shows activities similar to resveratrol, its levels in plants are significantly lower than those of resveratrol, 12) and it has therefore received far less research attention. We previously found that passion...

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“…Nobiletin (15), piceatannol (16) were purified from a peel of Citrus unshiu and Callistemon rigidus, respectively. Rosmarinic acid and lithospermic acid (17) were purified from Lithospermum erythrorhizon.…”

Section: Methodsmentioning

confidence: 99%

Effect of natural flavonoids, stilbenes and caffeic acid oligomers on protein glycation

2014

Self Cite

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Abstract. The aim of the present study was to identify the inhibitory activity of natural flavonoids, stilbenes and caffeic acid oligomers on protein glycation. Antioxidant activity was evaluated using 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activity. The production of 3-deoxyglucosone (3-DG) and advanced glycation end products (AGEs) by glycation reactions were determined by high-performance liquid chromatography and fluorescence, respectively. Certain flavonoids, stilbenes and caffeic acid oligomers prevented AGE production and the IC 50 values of the compounds were compared. These examined compounds are assumed to suppress AGE generation by inhibiting the increase in 3-DG production through a specific unknown mechanism in the early phase of the Maillard reaction, by inhibiting the generation of active oxygen in the later phase and by suppressing the progression of the reaction. Regular, daily consumption of these compounds in the form of a food or extract is expected to aid in the prevention or inhibition of non-enzymatic amino acid glycation in the living body, which is possibly associated with aging, diabetic complications, arteriosclerotic diseases and Alzheimer's disease, and they may also be effective agents in cosmetics promoting anti-aging.

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Constituents of Stem Bark of Callistemon rigidus Showing Inhibitory Effects on Mouse .ALPHA.-Amylase Activity

Cited by 34 publications

References 14 publications

Inhibitors ofα-glucosidase andα-amylase fromCyperus rotundus

Inhibitors ofα-glucosidase andα-amylase fromCyperus rotundus

Piceatannol Lowers the Blood Glucose Level in Diabetic Mice

Effect of natural flavonoids, stilbenes and caffeic acid oligomers on protein glycation

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