Constituents of Rhizome Essential Oils of Two Types of<i>Cyperus articulatus</i>L. Grown in Nigeria

Olawore, Nureni O.; Usman, L. A.; Ogunwande, Isiaka A.; Adeleke, Kasali A.

doi:10.1080/10412905.2006.9699179

Cited by 24 publications

(18 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cedrol is a sesquiterpene alcohol best known for its presence in the essential oil of conifers, especially in the genera Cupressus and Juniperus . However, it has been found in a large variety of plants including Sorghum [ 41 ], Artemisia [ 42 ] and swamp grasses of the genus Cyperus [ 43 ], which are all common in the study area. Sesquiterpenes are also known metabolites of fungi and to some extent bacteria [ 44 - 46 ].…”

Section: Discussionmentioning

confidence: 99%

Discovery of an oviposition attractant for gravid malaria vectors of the Anopheles gambiae species complex

Lindh

Okal

Herrera-Varela

et al. 2015

Malar J

View full text Add to dashboard Cite

BackgroundNew strategies are needed to manage malaria vector populations that resist insecticides and bite outdoors. This study describes a breakthrough in developing ‘attract and kill’ strategies targeting gravid females by identifying and evaluating an oviposition attractant for Anopheles gambiae s.l.MethodsPreviously, the authors found that gravid An. gambiae s.s. females were two times more likely to lay eggs in lake water infused for six days with soil from a natural oviposition site in western Kenya compared to lake water alone or to the same but autoclaved infusion. Here, the volatile chemicals released from these substrates were analysed with a gas-chromatograph coupled to a mass-spectrometer (GC-MS). Furthermore, the behavioural responses of gravid females to one of the compounds identified were evaluated in dual choice egg-count bioassays, in dual-choice semi-field experiments with odour-baited traps and in field bioassays.ResultsOne of the soil infusion volatiles was readily identified as the sesquiterpene alcohol cedrol. Its widespread presence in natural aquatic habitats in the study area was confirmed by analysing the chemical headspace of 116 water samples collected from different aquatic sites in the field and was therefore selected for evaluation in oviposition bioassays. Twice as many gravid females were attracted to cedrol-treated water than to water alone in two choice cage bioassays (odds ratio (OR) 1.84; 95% confidence interval (CI) 1.16-2.91) and in experiments conducted in large-screened cages with free-flying mosquitoes (OR 1.92; 95% CI 1.63-2.27). When tested in the field, wild malaria vector females were three times more likely to be collected in the traps baited with cedrol than in the traps containing water alone (OR 3.3; 95% CI 1.4-7.9).ConclusionCedrol is the first compound confirmed as an oviposition attractant for gravid An. gambiae s.l. This finding paves the way for developing new ‘attract and kill strategies’ for malaria vector control.Electronic supplementary materialThe online version of this article (doi:10.1186/s12936-015-0636-0) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Discovery of an oviposition attractant for gravid malaria vectors of the Anopheles gambiae species complex

Lindh

Okal

Herrera-Varela

et al. 2015

Malar J

View full text Add to dashboard Cite

show abstract

“…Quali-quantitative differences in the composition of volatile oils may be due to the influence of several factors such as temperature, luminosity, seasonality, developmental stage, harvesting time, water availability, UV radiation, altitude, air pollution, nutrients, pathogens etc. (Adams 2007;Olawore et al 2006;Hassanein et al 2014).…”

Section: Acta Amazonicamentioning

confidence: 99%

In vitro and in vivo antimalarial activity of the volatile oil of Cyperus articulatus (Cyperaceae)

et al. 2019

View full text Add to dashboard Cite

Malaria is a disease of global tropical distribution, being endemic in more than 90 countries and responsible for about 212 million cases worldwide in 2016. To date, the strategies used to eradicate this disease have been ineffective, without specific preventive measures such as vaccines. Currently, the existing therapeutic arsenal is limited and has become ineffective against the expansion of artemisinin-resistant Plasmodium, demonstrating the need for studies that would allow the development of new compounds against this disease. In this context, we studied the volatile oil obtained from rhizomes of Cyperus articulatus (VOCA), a plant species commonly found in the Amazon region and popularly used as a therapeutic alternative for the treatment of malaria, in order to confirm its potential as an antimalarial agent by in vitro and in vivo assays. We cultured Plasmodium falciparum W2 (chloroquine-resistant) and 3D7 (chloroquine-sensitive) strains in erythrocytes and exposed them to VOCA at different concentrations in 96-well microplates. In vivo antimalarial activity was tested in BALB/c mice inoculated with approximately 106 erythrocytes infected with Plasmodium berghei. VOCA showed a high antimalarial potential against the two P. falciparum strains, with IC50 = 1.21 μg mL-1 for W2 and 2.30 μg mL-1 for 3D7. VOCA also significantly reduced the parasitemia and anemia induced by P. berghei in mice. Our results confirmed the antimalarial potential of the volatile oil of Cyperus articulatus.

show abstract

“…Germacrone (1) is found as part of the essential oils of different plants that are widely distributed throughout the world (for example, Bulgaria, Bolivia, Vietnam, Alaska, China, Serbia, India, North America, Nigeria, Formosa [13], Asarum caulescens [14], Pogostemon formosanus [15], Ledum palustre [16], Artemisia lagopus [17], Fluorensia oolepis [18], Fagara macrophylla [19], Magnolia grandiflora [20], Hyptis mutabilis [21], Commiphora myrrha [22], Acanthogorgia vagae [23], Lallemantia iberica [24], Chloranthus spicatus [25], Cyperus articulatus [26], and Metrosideros diffusa [27]. In addition, 1 is noteworthy for its abundance in different essential oils (with yields higher than 20% of the total oil [36], and Pogostemon formosanus (36.6%) [37].…”

Section: Occurrencementioning

confidence: 99%

Germacrone: Occurrence, Synthesis, Chemical Transformations and Biological Properties

Barrero

Herrador

Arteaga

et al. 2008

Natural Product Communications

View full text Add to dashboard Cite

This paper is dedicated to Professor Pedro Joseph-Nathan for his 65 th birthday. Germacrone (1) forms part of a great number of essential oils, in some of them comprising more than 20% of the total oil. This compound presents a wide range of biological activities (CNS depressant, antiinflammatory, antiulcer, antifeedant, antibacterial, antifungal, antitumor, antitussive, vasodilator, choleretic, hepatoprotector), which are analyzed. The chemical reactivity of germacrone, including cyclization reactions, and complete synthesis are presented.

show abstract

Constituents of Rhizome Essential Oils of Two Types ofCyperus articulatusL. Grown in Nigeria

Cited by 24 publications

References 9 publications

Discovery of an oviposition attractant for gravid malaria vectors of the Anopheles gambiae species complex

Discovery of an oviposition attractant for gravid malaria vectors of the Anopheles gambiae species complex

In vitro and in vivo antimalarial activity of the volatile oil of Cyperus articulatus (Cyperaceae)

Germacrone: Occurrence, Synthesis, Chemical Transformations and Biological Properties

Contact Info

Product

Resources

About