Constituents of Morus alba var. multicaulis leaf improve lipid metabolism by activating the AMPK signaling pathway in HepG2 cells

Huang, Peijian; Hao, Mimi; Gao, Qian; Ruan, Jing; Yang, Shuxu; Li, Mengyang; Chen, Qian; Zhang, Yi; Wang, Tao

doi:10.1007/s11418-021-01581-3

Cited by 6 publications

(7 citation statements)

References 27 publications

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“…It had a molecular formula of C 19 H 30 O 10 as determined by positive HRESIMS with a [M + Na] + ion peak at m/z 441.1734 (calcd for C 19 H 30 O 10 Na + , 441.1731). The 1 H and 13 C NMR data (Table 1) of 1 were similar to those of 2-[4-(3-hydroxypropyl)-2methoxyphenoxy]propane-1,3-diol [10] except for a hexose residue in 1. In addition, the chemical shift of C-9 of 1 was shifted downfield by 4.1 ppm, indicating the sugar group was located at C-9 position.…”

Section: Resultsmentioning

confidence: 77%

“…The eight known analogues were identified as eugenyl-α-larabinofuranosyl-(1!6)-β-d-glucopyranoside (5), [13] canthoside A (6), [14] icariside D 1 (7), [15] 3-hydroxyphenethyl alcohol 4-O-β-dglucopyranoside (8), [16] henryoside (9), [17] virgaureoside A (10), [18] (+)-syringaresinol 4-O-β-d-glucoside (11), [19] and (7R,8S)-erythro-7,9,9'-trihydroxy-3,3'-dimethoxy-8-O-4'-neolignan-4-O-β-d glucopyranoside (12) [20] glucopyranoside (12) [20] by comparison of the spectroscopic results and literature data.…”

Section: Resultsmentioning

confidence: 99%

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Phenolic Glycosides from Viburnum chinshanense Leaves and their α‐Amylase and α‐Glucosidase Inhibitory Activity

Zhou,

Yang,

Chen

et al. 2024

Chemistry & Biodiversity

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The phytochemical investigation of Viburnum chinshanense leaves led to the isolation and identification of four new phenolic glycosides, viburninsides A−D (1−4), and eight known analogues (5−12). The structures of the four undescribed compounds were determined by spectroscopic techniques, including 1D NMR, 2D NMR, and HRESIMS, and their containing sugar units were confirmed by acid hydrolysis and HPLC analysis of the monosaccharide's chiral derivatives. Additionally, the α‐amylase and α‐glucosidase inhibitory activities of the isolated compounds were assessed. Compounds 1, 2, 4, 9, and 10 exhibited potential inhibitory activities against α‑amylase and α‐glucosidase with IC50 values ranging from 35.07 μM to 47.42 μM and 18.27 μM to 43.65 μM, respectively. Molecular docking analysis of compound 4 with the strongest inhibition against the target enzymes was also conducted.

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Section: Resultsmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Phenolic Glycosides from Viburnum chinshanense Leaves and their α‐Amylase and α‐Glucosidase Inhibitory Activity

Zhou,

Yang,

Chen

et al. 2024

Chemistry & Biodiversity

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“…Twenty-two known compounds were identified as quercetin-3- O - β -D-rhamnopyranoside ( 4 ) [ 17 ], 6-methoxy-naringenin ( 5 ) [ 18 ], 6-methoxy-kaempferol ( 6 ) [ 19 ], kaempferol ( 7 ) [ 20 ], apigenin ( 8 ) [ 21 ], abscisic acid ( 9 ) [ 22 ], (+)-dehydrovomifoliol ( 10 ) [ 23 ], grasshopper ketone ( 11 ) [ 24 ], roseoside ( 12 ) [ 25 ], citroside A ( 13 ) [ 23 ], 4′-(6-amino-9 H -purin-9-yl)pentan-2′-one ( 14 ) [ 26 ], seco-( S -Pro- R -Val) (1 5 ) [ 27 ], cyclo-( L -Pro- L -Ala) ( 16 ) [ 28 ], 3-methoxyl-1 H -pyrrole ( 17 ) [ 29 ], cyclo-(Ala-Val) ( 18 ) [ 30 ], indole-3-carboxyl- β -D-glucopyranoside ( 19 ) [ 31 ], uridine ( 20 ) [ 32 ], thymidine ( 21 ) [ 33 ], adenosine ( 22 ) [ 34 ], hypoxanthine ( 23 ) [ 35 ], aurantiamide acetate ( 24 ) [ 36 ], and L -pyroglutamic acid methyl ester ( 25 ) [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Constituents from the Flowers of Carthamus tinctorius L. and Their Lung Protective Activity

et al. 2022

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A new flavonoid, saffloflavanside (1), a new sesquiterpene, safflomegastigside (2), and a new amide, saffloamide (3), together with twenty-two known compounds (4–25), were isolated from the flowers of Carthamus tinctorius L. Their structures were determined based on interpretation of their spectroscopic data and comparison with those reported in the literature. The protective effects against lipopolysaccharide (LPS)-stimulated damage on human normal lung epithelial (BEAS-2B) cells of the compounds were evaluated using MTT assay and cellular immunofluorescence assay. The results showed that compounds 2–3, 8–11, and 15–19 exhibited protective effects against LPS-induced damage to BEAS-2B cells. Moreover, compounds 2–3, 8–11, and 15–19 can significantly downregulate the level of nuclear translocation of NF-κB p-p65. In summary, this study revealed chemical constituents with lung protective activity from C. tinctorius, which may be developed as a drug for the treatment of lung injury.

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“…The HPLC chromatogram of MLE generated by full-scan diode array detector (PDA) and the structures of identified components were shown in Figure 1A,B, respectively. These compounds have been identified in mulberry leaves and the flavonoids were major components in MLE [25,26]. components with higher peak areas in HPLC (3-5) were compared with commercial standards, and the identities of the compounds were confirmed.…”

Section: The Main Components In Mlementioning

confidence: 92%

Section: The Main Components In Mlementioning

confidence: 99%

Mulberry Leaf Extract Improves Metabolic Syndrome by Alleviating Lipid Accumulation In Vitro and In Vivo

Xing

Ren

et al. 2022

Molecules

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Metabolic syndrome (MS) is a metabolic disease with multiple complications. Mulberry leaf extract (MLE) is rich in flavonoids and has great potential in alleviating glucose and lipid metabolism disorders. This study evaluated the effect and mechanism of MLE on the alleviation of MS. The components of the MLE were analyzed, and then the regulation of lipid metabolism by MLE in vitro and in vivo was determined. In a hepatocyte model of oleic acid-induced lipid accumulation, it was found that MLE alleviated lipid accumulation and decreased the expression of genes involved in lipogenesis. Furthermore, MLE improved obesity, insulin resistance, plasma lipid profile, and liver function in MS mice after a 15-week intervention. MLE decreased the expression of SREBP1, ACC, and FAS through the AMPK signaling pathway to inhibit lipid synthesis and increase the level of CPT1A to promote lipid decomposition to achieve its hypolipidemic effect. Meanwhile, MLE was also shown to affect the composition of the gut microbiota and the production of short-chain fatty acids, which contributed to the alleviation of lipid accumulation. Our results suggest that MLE can improve MS by improving lipid metabolism through multiple mechanisms and can be developed into dietary supplements for the improvement of MS.

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Constituents of Morus alba var. multicaulis leaf improve lipid metabolism by activating the AMPK signaling pathway in HepG2 cells

Cited by 6 publications

References 27 publications

Phenolic Glycosides from Viburnum chinshanense Leaves and their α‐Amylase and α‐Glucosidase Inhibitory Activity

Phenolic Glycosides from Viburnum chinshanense Leaves and their α‐Amylase and α‐Glucosidase Inhibitory Activity

Chemical Constituents from the Flowers of Carthamus tinctorius L. and Their Lung Protective Activity

Mulberry Leaf Extract Improves Metabolic Syndrome by Alleviating Lipid Accumulation In Vitro and In Vivo

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