Constituents of Eriobotrya japonica. A Study of Their Antiviral Properties

Tommasi, Nunziatina De; Simone, Francesco De; Pìzza, Cosimo; Mahmood, Naheed; Moore, Patrick S.; Conti, Cinzia; Orsi, N; Stein, M. L.

doi:10.1021/np50086a006

Cited by 86 publications

(50 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among Chinese medicine preparations, Eriobotrya japonica folia are an ingredient in Shini-seihai-to and Biwayo-to used as antiphlogistic, analgesic, antitussive, and expectorant agents. Recently, the blood sugar-reducing 9-11) and antiphlogistic actions 12,13) of Eriobotrya japonica folia have also been reported. On the other hand, Eriobotrya japonica seeds, like those of apricots and peaches of the same genus (Rosaceae), contain amygdalin as the main constituent; therefore, they were used as a substitute medication for the latter seeds in prewar Japan.…”

mentioning

confidence: 99%

The Effect of Eriobotrya japonica Seed Extract on Oxidative Stress in Adriamycin-Induced Nephropathy in Rats

Hamada

Yoshioka

Takuma

et al. 2004

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Recent studies have shown that oxidative damage in the body induced by reactive oxygen species (ROS) and free radicals is frequently involved in the development of many diseases.1-3) ROS are continuously produced physiologically, and play an important role in the expression of cell functions such as the transmission of impulse information. However, if they are produced excessively from any cause, they act cytotoxically as mediators of adverse events such as inflammation, necrosis, and apoptosis. In the kidney, ROS are important causes of acute and subacute renal failure in most cases. It has also been reported that renal failure results from decreased levels of the antioxidant vitamin E and decreased activity of the antioxidant enzyme glutathione peroxidase (GPx), 4,5) and can be prevented by free-radical scavengers and polyphenols. 6,7) Also, certain anticancer drugs themselves produce free radicals, and act as factors promoting nephrotoxicity. 8) In particular, adriamycin (ADR), which is used to treat leukemia and lung cancer, generates superoxide anions and hydroxy radicals, thereby inducing nephrotoxicity, suggesting that the administration of antioxidant substances is effective in inhibiting nephrotoxicity. However, no clinically useful drugs are currently available.Eriobotrya japonica is widely cultivated as a fruit crop. Among Chinese medicine preparations, Eriobotrya japonica folia are an ingredient in Shini-seihai-to and Biwayo-to used as antiphlogistic, analgesic, antitussive, and expectorant agents. Recently, the blood sugar-reducing 9-11) and antiphlogistic actions 12,13) of Eriobotrya japonica folia have also been reported. On the other hand, Eriobotrya japonica seeds, like those of apricots and peaches of the same genus (Rosaceae), contain amygdalin as the main constituent; therefore, they were used as a substitute medication for the latter seeds in prewar Japan.To date, we have discovered the antioxidant action and associated hepatotoxicity-inhibiting action of an extract from Eriobotrya japonica seeds.14) In this study, to clarify the physiological action of an extract from Eriobotrya japonica seeds, we administered an Eriobotrya japonica seed extract (ESE) with 70% ethanol to rats with ADR nephrotoxicity, and evaluated its improvement effect. MATERIALS AND METHODS MaterialsSufficiently sun-dried seeds of Mogi-loquant collected at Muroto and Susaki cities in Kochi Prefecture of Japan were the Eriobotrya japonica seeds used. Adriamycin (ADR) was provided by Kyowahakko (Japan). All other chemicals were of reagent grade.Extraction of Seed Eriobotrya japonica seeds were extracted by 70% ethanol. Briefly, 1.0 kg of seeds was crushed in a blender equipped with a refrigerator at 1000 rpm, and then continuously stirred by a mixer at 300 rpm for 7 d after being dissolved in the 70% ethanol. The supernatant was then collected and evaporated to dryness to prepare the dried extracts.Animals Male Wistar rats, aged seven weeks, 180-200 g, were purchased from NSC Japan. Animals were acclimatized for seven days ...

show abstract

mentioning

confidence: 99%

The Effect of Eriobotrya japonica Seed Extract on Oxidative Stress in Adriamycin-Induced Nephropathy in Rats

Hamada

Yoshioka

Takuma

et al. 2004

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…japonica leaves contain triterpenes, sesquiterpenes, flavonoids, tannins, and amygdalin [1,2]. Among them, the triterpenes from E. japonica leaves might be expected to have potent bioactivities in vivo and in vitro [3].…”

Section: Hplc Fingerprinting Of Triterpenes In Eriobotrya Japonica Lementioning

confidence: 99%

“…The dried leaves of E. japonica are used in Japanese Kampo medicines and Traditional Chinese Medicines (TCM) for chronic bronchitis, cough, skin disease, inflammation, and diabetes. Previous phytochemical investigations have demonstrated that E. japonica leaves contain triterpenes, sesquiterpenes, flavonoids, tannins, and amygdalin [1,2]. Among them, novel biological properties of triterpenes, such as the attenuation of glycosylated serum protein, total cholesterol, and triglyceride level in diabetic mice have been reported [3].…”

Section: Introductionmentioning

confidence: 99%

Bioactivities of Eriobotrya japonica (Thunb.) Lindl. Leaf and Its Triterpenes

Uto¹,

Tung²,

Nakajima³

et al. 2017

J Pharmacogn Nat Prod

View full text Add to dashboard Cite

The dried leaves of Eriobotrya japonica have traditionally been widely used to treat various diseases, such as chronic bronchitis, cough, inflammation, skin disease, and diabetes. Our previous studies have reported several functions and their molecular mechanisms of E. japonica leaf extract and triterpenes contained in the extract. In this review article, we focus on the effects of E. japonica leaf extract and triterpenes on inflammatory mediators, proliferation of cancer cells, and ghrelin production. 1) The leaf extract of E. japonica suppressed inflammatory mediators including nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) production in lipopolysaccharide (LPS)-stimulated RAW264 murine macrophage cells. The anti-inflammatory properties of E. japonica leaf extract resulted from inhibition of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions through downregulation of nuclear factor-κB (NF-κB) activation and mitogen-activated protein kinases (MAPK) phosphorylation. 2) E. japonica leaves contain triterpenes such as corosolic acid, ursolic acid, maslinic acid, and oleanolic acid. Corosolic acid exterted the strongest anti-proliferative activity in human leukemia cell lines. Moreover, corosolic acid induced apoptosis mediated by mitochondrial dysfunction and caspase activation. 3) Ghrelin is an appetite-stimulating peptide hormone with an octanoyl modification at serine 3 that is essential for its orexigenic effect. Our investigation of triterpenes from E. japonica, corosolic acid, oleanolic acid, and ursolic acid suppressed octanoylated ghrelin levels in AGS-GHRL8 cell line, which produces octanoylated ghrelin in the presence of octanoic acid, without decreasing transcript expression of ghrelin O-acyltransferase (GOAT) or furin.

show abstract

“…비파 잎에는 다양한 terpenoid (Nazato et al 1984)와 플라보노이드 (Jung et al 1999 (Nazato et al 1994;Jung et al 1994;Taniguchi et al 2002). 이 밖에도 비파 잎, 씨 또는 과육에 다량 함유되어 있는 유용한 화합물들의 항산화효과 (Jung et al 1994;Koba et al 2007;Lee et al 2009), 항 당뇨효과 (Chen et al 2008), 항염증 및 항암효과 Banno et al 2005;Huang et al 2007), 항바이러스효과 (De Tommasi et al 1992 Seedless fruit.…”

Section: 서론unclassified

Effects of Loquat (Eriobotrya japonica Lindl.) Ethanol Extracts of Different Aerial Parts on Antioxidant Activity and Antiproliferation of Human Cancer Cells

Lee¹,

Kim²,

Lee³

et al. 2016

KJCLS

View full text Add to dashboard Cite

The current study was carried out to determine the effects of the seed, flesh (seedless fruit), and leaf of loquat (Eriobotrya japonica Lindle.) on antioxidative activity and anti-proliferation in human cancer cells. Total polyphenol contents of loquat seed, flesh, and leaf ethanol extracts were found to be 17.77, 32.32, and 28.08 mg/g, respectively. Also, total flavonoid contents of loquat seed, flesh, and leaf ethanol extracts were found to be 18.77, 28.73, and 21.35 mg/g, respectively. The IC 50 values of DPPH hydroxyl scavenging of loquat seed, flesh, and leaf ethanol extracts were 0.049, 0.063, and 0.042 mg/mL, respectively. Antioxidative indexes of loquat leaf and seed ethanol extracts was highly and it was similar to the BHA and BHT. The antioxidative activities in loquat seed and leaf ethanol extracts were higher in loquat flesh. The antiproliferation effect of loquat seed and leaf ethanol extracts on liver cancer cell line (H460), stomach cancer cell line (AGS) and lung cancer cell line (A549) showed higher values compared with the flesh ethanol extracts. These results indicate that loquat ethanol extracts may play a positive role in antioxidative properties and cancer prevention.

show abstract

Constituents of Eriobotrya japonica. A Study of Their Antiviral Properties

Cited by 86 publications

References 18 publications

The Effect of Eriobotrya japonica Seed Extract on Oxidative Stress in Adriamycin-Induced Nephropathy in Rats

The Effect of Eriobotrya japonica Seed Extract on Oxidative Stress in Adriamycin-Induced Nephropathy in Rats

Bioactivities of Eriobotrya japonica (Thunb.) Lindl. Leaf and Its Triterpenes

Effects of Loquat (Eriobotrya japonica Lindl.) Ethanol Extracts of Different Aerial Parts on Antioxidant Activity and Antiproliferation of Human Cancer Cells

Contact Info

Product

Resources

About