Constituents of Couepia paraensis

Sanduja, Radhika; Alam, Mohammad Mahboob; Kl, Euler

doi:10.1021/np50025a019

Cited by 6 publications

(2 citation statements)

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“…[2][3][4][5] In biological systems, the production of ROS and RNS is important to maintain homeostasis. [9][10][11] Furthermore, there are other reports in the literature that support the presence of interesting bioactive compounds in the Couepia genus. 6 The Couepia bracteosa Benth species (Brazilian name: "pajurá") belongs to the Chrysobalanaceae R. Br.…”

Section: Introductionmentioning

confidence: 99%

“…However, tocopherols, flavonoids and derivatives and also triterpenes were reported for other species from the Couepia genus, such as C. edulis 8 and C. paraensis. [9][10][11] Furthermore, there are other reports in the literature that support the presence of interesting bioactive compounds in the Couepia genus. For example, the chemopreventive activity (induction of quinone reductase activity) of C. ulei compounds, 12 the antibacterial, antioxidant and cytotoxic activity against Artemia salina of C. grandiflora extracts, 13 and the anticancer activity (lyase inhibitors of DNA β-polymerase activity) of C. polyandra.…”

Section: Introductionmentioning

confidence: 99%

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The seed of the Amazonian fruit Couepia bracteosa exhibits higher scavenging capacity against ROS and RNS than its shell and pulp extracts

et al. 2015

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Among the large number of scientifically unstudied fruits from the Amazonia biome, Couepia bracteosa acts as an interesting source of bioactive compounds, such as phenolic compounds and carotenoids, which may be used for protecting human health against oxidative damage. For the first time, the phenolic compounds and carotenoids in extracts obtained from the pulp, shell and seeds of C. bracteosa fruits are reported, as well as their in vitro scavenging capacities against some reactive oxygen species (ROS) and reactive nitrogen species (RNS). The shell extract presented the highest phenolic compound and carotenoid contents (5540 and 328 μg per g extract, dry basis, respectively), followed by the pulp and seed extracts. The major phenolic compound was acacetin sulphate (one methoxy and two OH groups) (62%) in the shells; however, only seeds presented apigenin sulphate (three OH groups), in which it was the major compound (44%). The high content of apigenin sulphate may explain why the seed extract had the highest scavenging efficiency against all tested ROS/RNS among the studied extracts. Regarding carotenoids, all-trans-neochrome (17%) and all-trans-β-carotene (16%) were the major carotenoids in the pulp extracts, while all-trans-lutein (44%) was the most prevalent in the shell extracts and all-trans-α-carotene (32%) and all-trans-β-carotene (29%) were the major ones in the seed extracts.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The seed of the Amazonian fruit Couepia bracteosa exhibits higher scavenging capacity against ROS and RNS than its shell and pulp extracts

et al. 2015

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The minor flavonoids

Bohm¹

1988

The Flavonoids

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Phenolic compounds obtained from stems ofcouepia ulei with the potential to induce quinone reductase

et al. 2004

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Activity-guided fractionation of the EtOAc-soluble extract of the stems of Couepia ulei, using a bioassay based on the induction of quinone reductase (QR) in cultured Hepa 1c1c7 mouse hepatoma cells led to the isolation of two active compounds, a new natural product, erythro-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-ethoxypropan-1-ol (1), and a known compound, evofolin-B (2), along with five inactive compounds all of known structure, viz., betulinic acid, oleanolic acid, pomolic acid, (+/-)-syringaresinol, and ursolic acid. These isolates were identified by analysis of physical and spectral data. Compounds 1 and 2 exhibited QR inducing activity, with observed CD (concentration required to double induction) values of 16.7 and 16.4 microM, respectively.

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Constituents of Couepia paraensis

Cited by 6 publications

References 0 publications

The seed of the Amazonian fruit Couepia bracteosa exhibits higher scavenging capacity against ROS and RNS than its shell and pulp extracts

The seed of the Amazonian fruit Couepia bracteosa exhibits higher scavenging capacity against ROS and RNS than its shell and pulp extracts

The minor flavonoids

Phenolic compounds obtained from stems ofcouepia ulei with the potential to induce quinone reductase

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