Constituents of Caesalpinia crista from Indonesia

Awale, Suresh; Linn, Thein Zaw; Tezuka, Yasuhiro; Kalauni, Surya Kant; Banskota, Arjun H.; Attamimi, Faisal; Ueda, Junichi; Kadota, Shigetoshi

doi:10.1248/cpb.54.213

Cited by 38 publications

(15 citation statements)

References 15 publications

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“…[7][8][9] The purity of each diterpene was checked by TLC and 1 H-NMR spectrum, which did not show the presence of any impurity. Caesalpinins MA (1), ME-MJ (2-7), ML (8), and MO (9) and norcaesalpinins MC (10) and MD (11) were new compounds isolated from C. crista of Myanmar.…”

Section: Methodsmentioning

confidence: 99%

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Antimalarial Activity of Cassane- and Norcassane-Type Diterpenes from Caesalpinia crista and Their Structure-Activity Relationship

Kalauni

Awale

Tezuka

et al. 2006

Biological & Pharmaceutical Bulletin

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Section: Methodsmentioning

confidence: 99%

“…7) Thus, we carried out the detailed phytochemical investigation of this plant and isolated 40 new cassane-and norcassane-type diterpenes together with 18 known diterpenes. [7][8][9][10][11] In this paper, we report a biological profile on the antimalarial activity of the isolated diterpenes and their structure-activity relationships.…”

mentioning

confidence: 99%

Antimalarial Activity of Cassane- and Norcassane-Type Diterpenes from Caesalpinia crista and Their Structure-Activity Relationship

Kalauni

Awale

Tezuka

et al. 2006

Biological & Pharmaceutical Bulletin

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“…2 Caesalpinins H-P and norcaesalpinin F were isolated from the CH 2 Cl 2 extract of the seed kernels of Caesalpinia crista, together with 13 known diterpenes. 9 In Indonesia, seed kernel of this plant traditionally used for cough, malaria, and as anthelmintic. 6,10 Leaves for inflammation and liver disease, and the root was used for gastric and blood disorder.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, Total Flavonoid and Total Phenolic Content and Antioxidant Activity of Different Parts of Caesalpinia bonduc (L.) Roxb

Sembiring¹,

Elya²,

Sauriasari³

2017

172

118

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Background:Caesalpinia bonduc (L.) Roxb are traditionally used in Indonesia to treat various diseases, but still limited study about different part of this plant. Objective: The aim of this study was to screen the phytochemicals, to evaluate the total flavonoid and total phenolic contents as well as antioxidant activity of ethanol extract of root, stem, leaves, and seed kernel of C. bonduc. Methods: Each part of plant were extracted by reflux using 70% ethanol as the solvent for 2 h and repeated 3 times. Total flavonoid content was determined by aluminium chloride colorimetric assay on 415 nm. Total phenolic content was determined with Folin-Ciocalteu 1:4 on 765 nm using microplate reader. Antioxidant activity was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenger methods. Results: Phytochemical screening showed that all of samples positively contain flavonoid and saponin. Total flavonoid content was the highest in leaf and the lowest in root whereas total phenols content was highest in leaf and the lowest in seed kernel. The crude extracts displayed DPPH free radical scavenging activity with highest value in leaf extract followed by root, stem, and seed kernel. Conclusion: The 70% ethanol leaf extract of C. bonduc showed the highest yield, total flavonoid content and total phenolic content among other parts investigated. Moreover, leaf extract has highest DPPH free radical scavenging activity (79.802 µg/ml) which could be related to its higher phenolic content.

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“…Theses diterpenoids can be classified into eight categories: caesalpin, e.g., 14-deoxy-e-caesalpin [1]; neocaesalpin, e.g., neocaesalpin H [2]; caesaldekarin, e.g., caesaldekarin G [3]; caesalpinin, e.g., caesalpinin H [4]; caesalmin, e.g., caesalmin A [5]; bonducellin, e.g., bonducellpin D [6]; norcaesalpinin, e.g., norcaesalpinin F [4], and macrocaesalmin [4]. -The genus Caesalpinia is a rich source of cassane diterpenoids.…”

mentioning

confidence: 99%