Constituents of aromatic plants: eucalyptol

Vincenzi, M. De; Silano, Marco; Vincenzi, A. De; Maialetti, Francesca; Scazzocchio, Beatrice

doi:10.1016/s0367-326x(02)00062-x

Cited by 81 publications

(50 citation statements)

References 12 publications

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“…1,8-cineole is the major constituent of the volatile fractions in EG and ECA, whereas in EC the major constituent is citronellal with citronellol and spathulenol. According to the literature, compounds with highest reducing ability have delocalized chemical bonds [56][57][58][59][60] . Prior research suggested a strong positive correlation (R 2 = 0.99) between phenolic content and antioxidative potential [12,18,58,59] .…”

Section: Resultsmentioning

confidence: 99%

“…According to the literature, compounds with highest reducing ability have delocalized chemical bonds [56][57][58][59][60] . Prior research suggested a strong positive correlation (R 2 = 0.99) between phenolic content and antioxidative potential [12,18,58,59] . Polyphenols received wide attention because of their antioxidant properties which refers to their ability to prevent damage from ROS through radical scavenging or prevent the generation of these species by iron chelation [61] .…”

Section: Resultsmentioning

confidence: 99%

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Exploration of natural enzyme inhibitors with hypoglycemic potentials amongst Eucalyptus Spp. by in vitro assays

Dey¹,

Mitra²,

Katakam³

et al. 2014

WJD

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AIM:To investigate the presence and potency of natural enzyme inhibitors with hypoglycemic potentials amongst Eucalyptus Spp. by in vitro assays. METHODS:The leaf extracts of the three different Eucalyptus species [E. globulus (EG), E. citriodora (EC), E. camaldulensis (ECA)] were subjected to in vitro assay procedures to explore the prevalence of natural enzyme inhibitors (NEIs) after preliminary qualitative and quantitative phytochemical evaluations, to study their inhibitory actions against the enzymes like α-amylase, α-glucosidase, aldose reductase, angiotensin converting enzyme and dipeptidyl peptidase 4 playing pathogenic roles in type 2 diabetes. The antioxidant potential and total antioxidant capacity of the species were also evaluated. RESULTS:Major bioactive compounds like polyphenols (341.75 ± 3.63 to 496.85 ± 3.98) and flavonoids (4.89 ± 0.01 to 7.15 ± 0.02) were found in appreciable quantity in three species. Based on the IC50 values of the extracts under investigation, in all assays the effectivity was in the order of EG > ECA > EC. The results of the ferric reducing antioxidant power assay showed that the reducing ability of the species was also in the order of EG > ECA > EC. A strong correlation (R 2 = 0.81-0.99) was found between the phenolic contents and the inhibitory potentials of the extracts against the targeted enzymes. CONCLUSION:

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Exploration of natural enzyme inhibitors with hypoglycemic potentials amongst Eucalyptus Spp. by in vitro assays

Dey¹,

Mitra²,

Katakam³

et al. 2014

WJD

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“…Eucalyptus oil is generally compared to menthol because of its tendency to acts on receptors in the nasal mucosa, which help to alleviate nasal congestion. [21] …”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Antioxidant Activity of essential oil of Eucalyptus leaf

Mishra¹,

Sahu²,

Mishra³

et al. 2010

Pharmacognosy Journal

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A b s t R A c t barks, roots, fruits, buds, leaves and other parts of plant are considered as source of essential aromatic oils to cure several ailments. the antioxidant property has been shown to be important in recovery from several diseases. the essential oil extracted from eucalyptus leaves was tested for phytochemical analysis and antioxidant activities. the eucalyptus oil extracted from the leaves of Eucalyptus globulus family Myrtaceae was screened for the presence of phytochemicals and their effect on 2, 2-Diphenyl-1-picryl-hydrazyl radical (DPPH) and Nitric oxide free radical. Phytochemical screening of the plants showed the presence of flavonoids, terpenoids, saponins and reducing sugars. Eucalyptus globulus is not having any cardiac glycosides and anthraquinones. the free radical scavenging activity of the different concentrations of the leaf oil (10, 20, 40, 60 and 80% (v/v) in DMsO) of E. globulus increased in a concentration dependent fashion. In DPPH method, the oil in 80% (v/v) concentration exhibited 79.55 ± 0.82%. In nitric oxide radical scavenging assay method, it was found that 80% (v/v) concentration exhibited 81.54 ± 0.94% inhibition. It was concluded that leaf oil is potent inhibition of free radicals.

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“…Accidental ingestion by a 3-year-old boy was reported, causing depression of the central nervous system (16). Fatal episodes have also been reported in humans (17) resulting from accidental exposure and also from large-volume mouthwash ingestion that contributed to severe anion-gap metabolic acidosis and osmolar gap, resulting in multiple organ system failure and death (18).…”

Section: Introductionmentioning

confidence: 99%

Eucalyptol, an essential oil, reduces contractile activity in rat cardiac muscle

Soares

Damiani

Moreira

et al. 2005

Braz J Med Biol Res

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Eucalyptol is an essential oil that relaxes bronchial and vascular smooth muscle although its direct actions on isolated myocardium have not been reported. We investigated a putative negative inotropic effect of the oil on left ventricular papillary muscles from male Wistar rats weighing 250 to 300 g, as well as its effects on isometric force, rate of force development, time parameters, post-rest potentiation, positive inotropic interventions produced by Ca 2+ and isoproterenol, and on tetanic tension. The effects of 0.3 mM eucalyptol on myosin ATPase activity were also investigated. Eucalyptol (0.003 to 0.3 mM) reduced isometric tension, the rate of force development and time parameters. The oil reduced the force developed by steady-state contractions (50% at 0.3 mM) but did not alter sarcoplasmic reticulum function or post-rest contractions and produced a progressive increase in relative potentiation. Increased extracellular Ca 2+ concentration (0.62 to 5 mM) and isoproterenol (20 nM) administration counteracted the negative inotropic effects of the oil. The activity of the contractile machinery evaluated by tetanic force development was reduced by 30 to 50% but myosin ATPase activity was not affected by eucalyptol (0.3 mM), supporting the idea of a reduction of sarcolemmal Ca 2+ influx. The present results suggest that eucalyptol depresses force development, probably acting as a calcium channel blocker. Correspondence

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Constituents of aromatic plants: eucalyptol

Cited by 81 publications

References 12 publications

Exploration of natural enzyme inhibitors with hypoglycemic potentials amongst Eucalyptus Spp. by in vitro assays

Exploration of natural enzyme inhibitors with hypoglycemic potentials amongst Eucalyptus Spp. by in vitro assays

Phytochemical Screening and Antioxidant Activity of essential oil of Eucalyptus leaf

Eucalyptol, an essential oil, reduces contractile activity in rat cardiac muscle

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