Constituents of Aegle marmelos

Sharma, Baldev; Sharma, Perveen

doi:10.1055/s-2007-971486

Cited by 25 publications

(10 citation statements)

References 2 publications

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“…The results were similar to earlier reports [40,41]. The chromatogram of the HPTLC fingerprinting analysis of the methanol soluble fraction of the decoction scanned at 254 nm has been presented in Fig 1.…”

Section: Resultssupporting

confidence: 90%

Studies on the antidiarrhoeal activity of Aegle marmelos unripe fruit: Validating its traditional usage

Brijesh

Daswani

Tetali

et al. 2009

BMC Complement Altern Med

134

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BackgroundAegle marmelos (L.) Correa has been widely used in indigenous systems of Indian medicine due to its various medicinal properties. However, despite its traditional usage as an anti-diarrhoeal there is limited information regarding its mode of action in infectious forms of diarrhoea. Hence, we evaluated the hot aqueous extract (decoction) of dried unripe fruit pulp of A. marmelos for its antimicrobial activity and effect on various aspects of pathogenicity of infectious diarrhoea.MethodsThe decoction was assessed for its antibacterial, antigiardial and antirotaviral activities. The effect of the decoction on adherence of enteropathogenic Escherichia coli and invasion of enteroinvasive E. coli and Shigella flexneri to HEp-2 cells were assessed as a measure of its effect on colonization. The effect of the decoction on production of E. coli heat labile toxin (LT) and cholera toxin (CT) and their binding to ganglioside monosialic acid receptor (GM1) were assessed by GM1-enzyme linked immuno sorbent assay whereas its effect on production and action of E. coli heat stable toxin (ST) was assessed by suckling mouse assay.ResultsThe decoction showed cidal activity against Giardia and rotavirus whereas viability of none of the six bacterial strains tested was affected. It significantly reduced bacterial adherence to and invasion of HEp-2 cells. The extract also affected production of CT and binding of both LT and CT to GM1. However, it had no effect on ST.ConclusionThe decoction of the unripe fruit pulp of A. marmelos, despite having limited antimicrobial activity, affected the bacterial colonization to gut epithelium and production and action of certain enterotoxins. These observations suggest the varied possible modes of action of A. marmelos in infectious forms of diarrhoea thereby validating its mention in the ancient Indian texts and continued use by local communities for the treatment of diarrhoeal diseases.

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Section: Resultssupporting

confidence: 90%

Studies on the antidiarrhoeal activity of Aegle marmelos unripe fruit: Validating its traditional usage

Brijesh

Daswani

Tetali

et al. 2009

BMC Complement Altern Med

134

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“…It is claimed to be useful in treating pain, fever, inflammation, respiratory disorders, cardiac disorders, dysentery and diarrhoea (Dymock William et al, 1890;Kirtikar et al, 1935;Murugesa Mudaliar, 1988). More than 30 identified compounds from the leaves of Aegle marmelos have been reported (Chatterjee and Bose, 1952;Sharma et al, 1980;Chatterjee and Satyesh, 1994). The major constituents of the leaves extract were identified to be tannins, skimmianin, essential oil (mainly caryophyllene, cineole, citral, citronellal, d-limonene and eugenol), sterols and/or triterpenoids, including lupeol, ␤-and ␥-sitosterol, ␣-and ␤-amyrin, flavanoids (mainly rutin) and coumarins, including aegeline, marmesin and umbelliferone (Karawya et al, 1980).…”

Section: Introductionmentioning

confidence: 99%

Studies on the anti-inflammatory, antipyretic and analgesic properties of the leaves of Aegle marmelos Corr.

Veerappan

Miyazaki

Dhananjayan

2005

Journal of Ethnopharmacology

134

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“…The various physicochemical values of leaves such as ash values, extractive values, and loss on drying were determined according to the pharmacopoeial method. [10]…”

Section: Physicochemical Standardizationmentioning

confidence: 99%

Untitled

Agrawal¹

2017

IJGP

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Background: Ficus carica Linn. (Moraceae) is commonly known as edible fig. It has been cultivated by humans for over 5000 years. In India, it is cultivated in many parts of North India for its fruits. Aim: Due to the useful effect of leaves in skin diseases, pharmacognostical standardization of F. carica leaves was carried out. Material and Methods: Morphological examination showed that leaves are long, palmate-shaped, and dark green in color. The leaves powder had characteristic odor and taste. Transverse section of leaves showed upper and lower epidermis with covering and glandular trichomes, and midrib showed arc-shaped vascular bundle. Results: Successive extractive value was highest (23.60%) in case of aqueous extract. Mean ash values (%) were 23.04 (total), 6.48 (acid insoluble), and 12.69 (water soluble). Loss on drying was 5.9107%. Resin content was found 1.33%. Phytochemical screening of leaves powder showed the presence of carbohydrates, phenolic compounds, flavonoids, steroids, tannin, resin, and acidic compounds. Conclusion: Further work is needed to isolate, characterize, and quantify active constituents present in the leaves of F. carica by sophisticated techniques.

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Constituents of Aegle marmelos

Abstract: A new naturaly occurring alkaloid has been isolated from the rpe fruits of Aegle marmelos and characterized as 0-methyihalfordinol (I). Alloimperatorin methyl ether, hitherto unknown in the genus Aegle, and 0-isopentenyihalfordinol, earlier detected in leaves, were also obtained.

Cited by 25 publications

References 2 publications

Studies on the antidiarrhoeal activity of Aegle marmelos unripe fruit: Validating its traditional usage

Studies on the antidiarrhoeal activity of Aegle marmelos unripe fruit: Validating its traditional usage

Studies on the anti-inflammatory, antipyretic and analgesic properties of the leaves of Aegle marmelos Corr.

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