Constituents from the Leaves of <i>Nelumbo nucifera</i> Stimulate Lipolysis in the White Adipose Tissue of Mice

Ohkoshi, Emika; Miyazaki, Hiromi; Shindo, Kazutoshi; Watanabe, Hiroyuki; Yoshida, Aruto; Yajima, Hiroaki

doi:10.1055/s-2007-990223

Cited by 125 publications

(90 citation statements)

References 18 publications

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“…Some examples of the natural compounds involved in b3-adrenergic receptor activation are the various flavonoids in the leaf of Nelumbo nucifera (NN). Through this pathway, NN extract dietary supplementation resulted in significant suppression of body weight gain in A/J mice fed a HFD [67]. Caffeine, one of the major bioactive components in oolong tea (Thea sinensis) possesses both a positive charge and a hydrophobic area like that of adrenaline.…”

Section: Lipid Metabolismmentioning

confidence: 99%

Review Article: Herbal Approach for Obesity Management

Chandrasekaran¹,

Vijayalakshmi²,

Prakash³

et al. 2012

AJPS

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Obesity, a complex interplay between environmental and genetic factors and is associated with significant morbidity and mortality. Usage of herbs for the management of obesity in the recent times is attracting attention. A web and manual based literature survey was conducted to assess the amount of information available on the herbal products for weight management. Traditional literature, PubMed, Scopus, Google scholar databases were screened up to February 2012. The search words were "obesity", "herbal medicine/products/extracts", "medicinal plants", "traditional medicine", "Ayurvedic medicine" without narrowing/limiting searching words or elements. Publications only with abstracts/full articles and books were reviewed in the search. Based on the available literature, for many of the herbal and weight loss products, there is little published information and there have been no clinical trials or the level of evidence is limited. Our literature survey also indicated that these herbal products fall under an acceptable level of evidence or with no scientific background at all, or they have a scientific rational but not to an acceptance level. Attempts were made in the review to define the features of possible herbal weight loss product. An ideal herbal anti obesity product should reduce the weight by 10% over placebo of treatment by showing an evidence of improvement of bio markers like blood pressure, lipids and glycemia without any side effects.

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Section: Lipid Metabolismmentioning

confidence: 99%

Review Article: Herbal Approach for Obesity Management

Chandrasekaran¹,

Vijayalakshmi²,

Prakash³

et al. 2012

AJPS

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“…1-3) In particular, numerous biological activities, including antioxidant, 4,5) anti-human immunodeficiency virus (HIV), 6) antihyperlipidemic, 1) hepatoprotective, and antiobesity effects [7][8][9] have been reported from the leaves of N. nucifera. In addition, Mukherjee et al reported 24) Recently, N. nucifera semen extract was reported to improve memory in rats with scopolamine-induced dementia through the induction of choline acetyltransferase expression and inhibition of acetylcholinesterase (AChE).…”

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confidence: 99%

Selective Cholinesterase Inhibitory Activities of a New Monoterpene Diglycoside and Other Constituents from Nelumbo nucifera Stamens

Jung

Hyun

et al. 2010

Biological & Pharmaceutical Bulletin

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Nelumbo nucifera GAERTN., the family of Nelumbonaceae, is a perennial, rhizomatous, aquatic plant distributed throughout Asia, including India, China, and Egypt. The plant is comprised of: membranous, peltate, orbicular, and concave leaves; nut-contained and ovoid fruits; black, hard, and ovoid seeds; nodal roots. In Korea, China and India, various parts of N. nucifera have been used in foodstuffs and traditional medicine for the treatment of diarrhea, gastritis, insomnia, nervous prostration and as a haemostatic.1-3) In particular, numerous biological activities, including antioxidant, 4,5) anti-human immunodeficiency virus (HIV), 6) antihyperlipidemic, 1) hepatoprotective, and antiobesity effects [7][8][9] have been reported from the leaves of N. nucifera. In addition, Mukherjee et al. reported 24) Recently, N. nucifera semen extract was reported to improve memory in rats with scopolamine-induced dementia through the induction of choline acetyltransferase expression and inhibition of acetylcholinesterase (AChE).25) Even though individual parts of this plant have been the target of distinct biological and pharmacological research, there are limited studies of the stamens, with the exception of research focusing upon the antioxidant and rat lens aldose reductase (RLAR) inhibition [26][27][28] and anti-allergic activities 29) attributed to the flavonoids. Alzheimer's disease (AD) is a neurodegenerative disease and the most frequent and predominant cause of dementia in the elderly, provoking progressive cognitive decline, psychobehavior disturbances, memory loss, the presence of senile plaques, neurofibrillary tangles, and a decrease in cholinergic transmission. 30,31) Although the pathogenesis of AD is complicated and involved in numerous pathways, two major hypotheses are currently under consideration regarding the molecular mechanism, the cholinergic hypothesis and the amyloid cascade hypothesis. Thus, the focus herein is upon inhibitors of select cholinesterases (ChEs) to alleviate cholinergic deficits and improve neurotransmission and b-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1; aspartyl protease, b-secretase, and memapsin2) inhibitors to preclude formation and accumulation of amyloid b peptide (Ab). Pursuant to this, both could then be established as viable therapeutic targets for AD. [31][32][33][34] Given that numerous promising pharmaceuticals and nutraceuticals are constantly isolated from effective natural products, and that a previous study from this lab indicated potent antioxidant and RLAR inhibitory activities of N. nucifera stamens, this plant was chosen for ongoing investigations into anti-AD activities. The present work deals with the isolation and characterization of a new b-cyclogeraniol diglycoside (5), and four known compounds: cycloartenol (1); p-hydroxybenzoic acid (2); vanilloloside (3); 5Ј-Omethyladenosine (4). Furthermore, the inhibitory activities of 1-5 toward ChEs, including AChE and butyrylcholinesterase (BChE), and BACE1 were evaluated. Busanjin-gu, Busan 61...

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“…In particular, the leaves are known for diuretic and astringent properties, and are used to treat obesity. In subsequent experiments, dietary supplementation of NN resulted in a significant suppression of body weight gain in A/J mice fed a high-fat diet 10 .…”

Section: Diuretic and Astringentmentioning

confidence: 95%

Untitled

2016

IJPSR

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objectives: Nelumbo nucifera Gaertn (Nelumbonaceae) known by numerous common names including Indian lotus, sacred lotus, bean of India, or simply lotus is one of the most important medicinal plants. In this review there is discussion about therapeutic potential of the different parts of the plant (leaves, seeds, flower, and rhizome) which can be used in traditional system of medicine. This review also describes various compounds isolated from different parts of the plant and therapeutic benefits derived from those phytocontituents. The aim of this review is to summarize the pharmacological, phytochemical and therapeutical knowledge of Nelumbo nucifera Gaertn. Key findings: The pharmacological studies have shown that N. nucifera possesses various pharmacological activities like anti-ischemic, antioxidant, anticancer, antiviral, antiobesity, lipolytic, hypocholestemic, antipyretic, hepatoprotective, hypoglycemic, antidiarrhoeal, antifungal, antibacterial, anti-inflammatory and diuretic activities. Several different types of compounds have been derived from this plant belonging to different chemical groups, including alkaloids, flavonoids, glycosides triterpenoid, etc., with own therapeutic impact. So the pharmacological effects and various active ingredients of different parts of N. nucifera are well understood. Summary: This review will facilitate to gain all about the past scientific research and will provide the necessary information about the enormous pharmacological activities of Nelumbo nucifera Gaertn which will insist the researchers for future research to protect human beings from various types of diseases and may serves as a natural gold for the promotion of mankind.

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Constituents from the Leaves of Nelumbo nucifera Stimulate Lipolysis in the White Adipose Tissue of Mice

Cited by 125 publications

References 18 publications

Review Article: Herbal Approach for Obesity Management

Review Article: Herbal Approach for Obesity Management

Selective Cholinesterase Inhibitory Activities of a New Monoterpene Diglycoside and Other Constituents from Nelumbo nucifera Stamens

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