Constipation, laxative use and risk of colorectal cancer: The Miyagi Cohort Study

Watanabe, Tetsuo; Nakaya, Naoki; Kurashima, Koshi; Kuriyama, Shinichi; Tsubono, Yoshitaka; Tsuji, Ichiro

doi:10.1016/j.ejca.2004.06.014

Cited by 92 publications

(73 citation statements)

References 31 publications

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“…Increased intra-colonic pressure secondary to constipation can lead to weakness in the colon walls, particularly in the sigmoid colon, predisposing patients to diverticulosis (ADA, 2008). Long-term use of laxatives may be a risk factor for the development of colonrectal cancer, possibly because toxicants have more time to be absorbed by the lining of the colon (Brocklehurst et al, 1998;Jacobs, 1998;Roberts et al, 2003;Watanabe et al, 2004). Other complications that can develop from chronic constipation include decreased rectal sensitivity, The end of his ileum emptied rapidly during the meal, while his caecum and ascending colon filled.…”

Section: Symptomsmentioning

confidence: 95%

The use of abdominal massage to treat chronic constipation

Sinclair¹

2011

Journal of Bodywork and Movement Therapies

118

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Section: Symptomsmentioning

confidence: 95%

The use of abdominal massage to treat chronic constipation

Sinclair¹

2011

Journal of Bodywork and Movement Therapies

118

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“…Constipation and laxative use may increase colon cancer risk (category III evidence). However, mild dehydration seems not to be a confounder [47].…”

Section: Bladder and Colon Cancermentioning

confidence: 99%

Hydration and Disease

Manz

2007

Journal of the American College of Nutrition

102

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Many diseases have multifactorial origins. There is increasing evidence that mild dehydration plays a role in the development of various morbidities. In this review, effects of hydration status on acute and chronic diseases are depicted (excluding the acute effects of mild dehydration on exercise performance, wellness, cognitive function, and mental performance) and categorized according to four categories of evidence (I-IV). Avoidance of a high fluid intake as a precautionary measure may be indicated in patients with cardiovascular disorders, pronounced chronic renal failure (III), hypoalbuminemia, endocrinopathies, or in tumor patients with cisplatin therapy (IIb) and menace of water intoxication. Acute systemic mild hypohydration or dehydration may be a pathogenic factor in oligohydramnios (IIa), prolonged labor (IIa), cystic fibrosis (III), hypertonic dehydration (III), and renal toxicity of xenobiotica (Ib). Maintaining good hydration status has been shown to positively affect urolithiasis (Ib) and may be beneficial in treating urinary tract infection (IIb), constipation (III), hypertension (III), venous thromboembolism (III), fatal coronary heart disease (III), stroke (III), dental disease (IV), hyperosmolar hyperglycemic diabetic ketoacidosis (IIb), gallstone disease (III), mitral valve prolapse (IIb), and glaucoma (III). Local mild hypohydration or dehydration may play a critical role in the pathogenesis of several broncho-pulmonary disorders like exercise asthma (IIb) or cystic fibrosis (Ib). In bladder and colon cancers, the evidence on hydration status' effects is inconsistent.

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“…Constipation is a possible risk factor of colon cancer, (35)(36)(37)(38) and this can be relieved by exercise. (39)(40)(41)(42) High physical activity has been reported to be related to low prevalence of constipation in some, (43,44) but not all, studies.…”

Section: Discussionmentioning

confidence: 99%

Physical activity and colorectal cancer: The Fukuoka Colorectal Cancer Study

et al. 2006

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The number of cases of colorectal cancer in Japan has increased over the past few decades, and incidence rates are now among the highest in the world. The present investigation within the Fukuoka Colorectal Cancer Study, including 778 cases and 767 controls aged 20-74 years, examined the association between physical activity and colorectal cancer risk by subsite. Employment-associated and leisure time physical activity was assessed by a questionnaire and interview. Division of sites into the proximal and distal colon, as well as the rectum, revealed clear site-dependent protective effects, with adjustment for smoking, alcohol consumption, BMI and age. In males, greater job-related physical activity was associated with significant reduction of risk in the distal colon and rectum (P = 0.047 and 0.02, respectively), whereas total and moderate or hard non-job physical activity exerted effects limited to the rectum (P = 0.01 and 0.004, respectively). In females, job-related physical activity and moderate or hard non-job physical activity was also protective, but only in the distal colon. Separate assessment of the influence of BMI 10 years previous to the study showed increase in risk with obesity in males but not in females, limited to distal colon and rectum. The results of the present study indicate that physical activity associated with work and leisure-time exerts beneficial effects in Japanese, but not on the proximal colon. (Cancer Sci 2006; 97: 1099-1104)

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Constipation, laxative use and risk of colorectal cancer: The Miyagi Cohort Study

Cited by 92 publications

References 31 publications

The use of abdominal massage to treat chronic constipation

The use of abdominal massage to treat chronic constipation

Hydration and Disease

Physical activity and colorectal cancer: The Fukuoka Colorectal Cancer Study

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