Constipation – a difficult therapeutic problem

Dzierżanowski, Tomasz; Rydzewska, Grażyna

doi:10.5114/pg.2012.32063

Cited by 5 publications

(3 citation statements)

References 56 publications

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“…Furthermore, it is well documented that adding osmotic laxatives such as polyethylene glycol or lactulose can increase stool frequency and improve symptoms of constipation [ 12 ]. Sometimes prokinetic drugs are recommended; however, their effect is limited to the upper gastrointestinal tract [ 13 ].…”

Section: Functional Constipationmentioning

confidence: 99%

Butyric acid in functional constipation

Pituch¹,

Walkowiak²,

Banaszkiewicz³

2013

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Butyric acid, a short-chain fatty acid, is a major energy source for colonocytes. It occurs in small quantities in some foods, and in the human body, it is produced in the large intestine by intestinalkacteria. This production can be reduced in some cases, for which butyric acid supplementation may be useful. So far, the use of butyric acid in the treatment of gastrointestinal disorders has been limited because of its specific characteristics such as its rancid smell and rapid absorption in the upper gastrointestinal tract. In the Polish market, sodium butyrate has been recently made available, produced by the modern technology of microencapsulation, which allows the active substance to reach the small and large intestines, where butyrate easily dissociates into butyric acid. This article presents the potential beneficial mechanisms of action of butyric acid in defecation disorders, which are primarily associated with reductions in pain during defecation and inflammation in the gut, among others.

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Section: Functional Constipationmentioning

confidence: 99%

Butyric acid in functional constipation

Pituch¹,

Walkowiak²,

Banaszkiewicz³

2013

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“…W skrajnych przypadkach dochodzi do niedrożności przewodu pokarmowego wskutek nagromadzenia się zbitych mas kałowych [10,11]. Zaparcie stolca wywołane opioidami częściej wymaga przyjmowania leków przeczyszczających i słabiej reaguje na zwykłe środki przeczyszczające niż zaparcie z innych przyczyn [12]. Zaparcie stolca wiąże się także z dwukrotnie wyższym obciążeniem ekonomicznym wynikającym z kosztów stosowanych środków przeczyszczających, interwencji personelu medycznego, dodatkowych wizyt lekarskich i pielęgniarskich, dodatkowych hospitalizacji i ich wydłużenia [13].…”

Section: Wstępunclassified

The role of peripherally acting mu-opioid receptor antagonists (PAMORA) in the treatment of constipation in palliative care

Dzierżanowski¹

2019

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Zaparcie stolca wywołane opioidami (opioid-induced constipation-OIC) to najczęstszy objaw niepożądany stosowania analgetyków opioidowych. Jego leczenie jest trudne i w dużej mierze zależy od licznych nakładających się czynników dietetycznych, behawioralnych, zależnych od choroby oraz jatrogennych. Wymagana jest profilaktyka zaparcia wraz z rozpoczęciem podawania opioidu. W leczeniu OIC zaleca się w pierwszej kolejności stosowanie zwykłych środków przeczyszczających pomimo ich małej skuteczności. W razie ich nieskuteczności należy zastosować jeden z obwodowo działających antagonistów receptora opioidowego m-metylonaltrekson, naloksegol lub naldemedynę. Po uzyskaniu wypróżnienia należy kontynuować leczenie antagonistą. Słowa kluczowe: zaparcie, opieka paliatywna, obwodowo działające antagonisty receptora opioidowego m, PAMORA.

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“…Various other risk factors are associated with constipation, such as dietary habits (e.g. consumption of olive oil and meat), lifestyle factors (living in a large community or retirement home and immobility), pregnancy, frequency of breastfeeding, waist/hip ratio, anxiety and depression, clinical condition (comorbidities, other bowel disorders, previous hysterectomy and posterior colpocele), and the use of various medications including laxatives [2–4].…”

Section: Introductionmentioning

confidence: 99%

The occurrence and risk factors of constipation in inpatient palliative care unit patients vs. nursing home residents

Dzierżanowski¹,

Ciałkowska-Rysz

2018

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IntroductionConstipation is one of the most frequent clinical and nursing problems both in palliative care patients and in nursing home residents.AimTo assess the occurrence of constipation and its risk factors in adult inpatient palliative care units versus nursing homes.Material and methodsAn epidemiological study was performed in an inpatient hospice and a nursing home.ResultsFifty-one hospice patients and 49 nursing home residents were included in the study. Cancer was the main clinical condition in 90% of the palliative care patients (PCPs), and dementia or other psychotic disorders were predominant in the nursing home residents (NHRs). More PCPs had constipation than did NHRs (80% vs. 59%; p = 0.02), although none of the single constipation symptoms differed statistically between these two groups. The insufficient food intake was twice as severe in the hospice patients (p = 0.0001). 68.6% of PCPs took strong opioids, while none of the NHRs did. Three times more NHRs spent at least 50% of daytime in bed than did PCPs (73.5% vs. 23.5%; p < 0.0001).ConclusionsConstipation is very frequent in both palliative care patients and nursing home residents, but PCPs are more prone to it. The NHR and PCR groups should not be treated uniformly as the end-of-life population, referring to prevention and treatment of constipation, therapy needs, and the means enrolled for optimal symptom control.

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Constipation – a difficult therapeutic problem

Cited by 5 publications

References 56 publications

Butyric acid in functional constipation

Butyric acid in functional constipation

The role of peripherally acting mu-opioid receptor antagonists (PAMORA) in the treatment of constipation in palliative care

The occurrence and risk factors of constipation in inpatient palliative care unit patients vs. nursing home residents

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