Several sources of interference in memory are identified. These sources may be grossly classified as processing interference, i.e., that due to disruption of whatever activity occurs during the input or output of to-be-remembered material, or trace interaction, i.e., that due to interference among the stored memories themselves. The latter would appear to be due to simultaneous activation of correct and incorrect associations mediated by confusion among cue stimuli. A consideration of the means by which interference is reduced suggests that interfering associates are not weakened, unlearned, or suppressed except possibly when nominal stimuli are identical and sets of target and interfering items are temporally discriminable. Discriminative encoding of cue stimuli may eliminate these associations, if it operates at the perceptual level. Otherwise, potential interfering associates are activated, but may be rendered functionally impotent by discriminating them from correct associations on the basis of either backward association with discriminative stimulus attributes or differential contextual attributes such as frequency, time, order, and strength.The concept of interference in psychological theories of human performance is so ubiquitous that it is often taken for granted. While it is sometimes used as a synonym for task difficulty, it more commonly appears as description of performance decrements resulting from the learning or performance of other tasks. Whereas some theorists use the term as an explanatory concept, it should be apparent that it possesses limited power in this respect. Without further elaboration it does little more than provide an operational restriction on the cause of performance difficulty and provide a name for this class of behavioral phenomena. This paper is directed toward the theoretical elaboration of a subset of these phenomena: manifestations of interference in the act of remembering. Scarcely a serious theory of memory has been proposed which does not assign all or some memory failures to interference. The theoretical problem is straightforward and involves two related questions: What are the mechanisms by which interference is produced, and how does the learner overcome interference in order to exhibit successful memorial performance? While both of these questions will be considered here, it is not the purpose of this paper to present a detailed and comprehensive model for interference and interference reduction. The focus instead will be on providing evidence for the existence of various processes involved in interference and considering how learners may be expected to cope with interference in some of its various manifestations.