Constant heat stress reduces skeletal muscle protein deposition in broilers

Zuo, Jianjun; Xu, Mingming; Abdullahi, A. Y.; Ma, Limei; Zhang, Zhongyue; Feng, Dan

doi:10.1002/jsfa.6749

Cited by 51 publications

(48 citation statements)

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“…To our knowledge, this is the first study to address the correlation between plasma BCAA contents and the relative mRNA expressions of intestine mucosal sensing receptor genes ( T1R1 and T1R3 ) in heat‐stressed chickens. It is well known that, under heat conditions, fat tissue cannot be utilized as energy, and more fats would be deposited and affiliated to some organs, which may cause metabolic disturbance of stimulating lipid accumulation, increase de novo lipogenesis, and enhance amino acid catabolism for broilers . The increased concentrations of BCAAs in plasma observed on day 42 were likely a consequence of protein catabolism, and due to the transporters of amino acid were likely downregulated under heat stress condition, which might result in surplus amino acid retention and accumulation in the body.…”

Section: Discussionmentioning

confidence: 99%

“…The increased concentrations of BCAAs in plasma observed on day 42 were likely a consequence of protein catabolism, and due to the transporters of amino acid were likely downregulated under heat stress condition, which might result in surplus amino acid retention and accumulation in the body. Therefore, as a compensatory or adaptation mode, the energy of the body might be redistributed by accelerating protein decomposition, with higher concentrations of the BCAAs in plasma, inducing overexpression of taste sensing receptors in the intestinal tract, which were probably inducing the satiety and inhibiting hunger feeling, finally reducing appetite.…”

Section: Discussionmentioning

confidence: 99%

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Effects of chronic heat exposure on growth performance, intestinal epithelial histology, appetite‐related hormones and genes expression in broilers

et al. 2018

J Sci Food Agric

100

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of chronic heat exposure on growth performance, intestinal epithelial histology, appetite‐related hormones and genes expression in broilers

et al. 2018

J Sci Food Agric

100

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“…It has been proposed that heat stress impairs mitochondrial functions and induces oxidative damage in plasma, liver, heart and skeletal muscle of broilers [5]. Varasteh et al found differential gene expression of broiler intestine to heat stress [9], and Zuo et al identified a reduction in skeletal muscle protein deposition in response to high ambient temperature [33]. In addition to metabolic effects, altered immune response of broilers under heat stress has also been widely reported [9, 14, 34–39].…”

Section: Discussionmentioning

confidence: 99%

Liver transcriptome response to hyperthermic stress in three distinct chicken lines

et al. 2016

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BackgroundHigh ambient temperatures cause stress in poultry, especially for broiler lines, which are genetically selected for rapid muscle growth. RNA-seq technology provides powerful insights into environmental response from a highly metabolic tissue, the liver. We investigated the effects of acute (3 h, 35 °C) and chronic (7d of 35 °C for 7 h/d) heat stress on the liver transcriptome of 3-week-old chicks of a heat-susceptible broiler line, a heat-resistant Fayoumi line, and their advanced intercross line (AIL).ResultsTranscriptome sequencing of 48 male chickens using Illumina HiSeq 2500 technology yielded an average of 33.9 million, 100 base-pair, single-end reads per sample. There were 8 times more differentially expressed genes (DEGs) (FDR < 0.05) in broilers (n = 627) than Fayoumis (n = 78) when comparing the acute-heat samples to the control (25 °C) samples. Contrasting genetic lines under similar heat treatments, the highest number of DEGs appeared between Fayoumi and broiler lines. Principal component analysis of gene expression and analysis of the number of DEGs suggested that the AIL had a transcriptomic response more similar to the Fayoumi than the broiler line during acute heat stress. The number of DEGs also suggested that acute heat stress had greater impact on the broiler liver transcriptome than chronic heat stress. The angiopoietin-like 4 (ANGPTL4) gene was identified as differentially expressed among all 6 contrasts. Ingenuity Pathway Analysis (IPA) created a novel network that combines the heat shock protein family with immune response genes.ConclusionsThis study extends our understanding of the liver transcriptome response to different heat exposure treatments in distinct genetic chicken lines and provides information necessary for breeding birds to be more resilient to the negative impacts of heat. The data strongly suggest ANGPTL4 as a candidate gene for improvement of heat tolerance in chickens.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-3291-0) contains supplementary material, which is available to authorized users.

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“…Different physiological responses may occur during heat stress and they depend on the intensity, severity, and duration of heat stress (Azad et al, 2010), thereby causing higher or lower levels of glucocorticoid release (Gonzalez-Esquerra and Leeson, 2006). These physiological responses are: changes in the functional integrity of the intestinal mucosa (Horn et al, 2009), body temperature increase (Marchini et al, 2007;Mitchell and Lemme, 2008), muscle degradation (Zuo et al, 2015), and increase in mortality rate (Estrada-Pareja et al, 2007) when high environmental temperatures coincide with the age to market (Arjona et al, 1988).…”

Section: Physiological Changes Induced By Heat Stress In Broilersmentioning

confidence: 99%

Physiology, cell dynamics of small intestinal mucosa, and performance of broiler chickens under heat stress: a review

Marchini

Café

Araújo

et al. 2016

Rev Colomb Cienc Pecu

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Physiology, cell dynamics of small intestinal mucosa, and performance of broiler chickens under heat stress: a review ¤ Fisiología, dinámica celular de la mucosa del intestino delgado y rendimiento de pollos de engorde sometidos a estrés calórico: revisión de literatura Fisiologia, dinâmica celular da mucosa do intestino delgado e desempenho de frangos de corte submetidos ao estresse pelo calor: revisão de literatura SummaryHigh room temperature reduces production efficiency of broiler chickens. Different factors contribute to this situation: fast growth, physiological variations, and changes in the small intestine mucosa. This review aims to define the concept of heat stress and its effects on several physiological aspects related to the development of the small intestine mucosa and the performance of broiler chickens. Heat stress triggers a corticosteroid increase and a circulating triiodothyronine hormone (T 3 ) reduction, increases respiratory frequency, which triggers respiratory alkalosis, diminishes food intake, and leads to changes in the cellular dynamics of the small intestine mucosa. These changes depend on animal genotype, intensity, and duration of the stressor. Acute heat stress leads to a reduction in enterocyte proliferation and also to a decrease in crypt depth, without affecting villus height or villus/crypt ratio. On the other hand, chronic stress diminishes villus height and jejunum weight. These changes affect the capacity of broilers to digest and absorb the nutrients required for maintenance and production. ResumenUna alta temperatura ambiente disminuye la eficiencia de la producción de pollos de engorde. Diversos factores contribuyen a esta situación: crecimiento rápido, cambios fisiológicos, y anomalías de la mucosa del intestino delgado. El objetivo de la presente revisión fue definir el concepto de estrés calórico y sus efectos sobre algunos aspectos de la fisiología, en el desarrollo de la mucosa del intestino delgado, y en el rendimiento de pollos de engorde. El estrés calórico desencadena un aumento de los niveles de corticosteroides, reducción de la hormona triyodotironina (T 3 ) circulante, aumento en la frecuencia respiratoria que resulta en alcalosis respiratoria, disminuye la ingesta de alimentos y provoca cambios en la dinámica celular de la mucosa del intestino delgado. Estos cambios dependen del genotipo del animal y de la intensidad y duración de la acción del factor estresante. El estrés calórico agudo causa una disminución en la proliferación de enterocitos, reducción de la profundidad de las criptas sin cambio en la altura de las vellosidades y en la relación vellosidades/cripta. Ya el estrés crónico disminuye la altura de las vellosidades y el peso del yeyuno. Estos cambios afectan la capacidad del pollo de engorde para digerir y absorber los nutrientes para su mantenimiento y producción. Palabras clave: corticoesteroides, hallazgos microscópicos, hallazgos morfológicos, proliferación de enterocitos, tracto gastrointestinal. ResumoA temperatura ambiente elevada diminu...

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Constant heat stress reduces skeletal muscle protein deposition in broilers

Abstract: Poor performance of the birds under heat stress may be due to lower synthesis and increased degradation of proteins.

Cited by 51 publications

References 55 publications

Effects of chronic heat exposure on growth performance, intestinal epithelial histology, appetite‐related hormones and genes expression in broilers

Effects of chronic heat exposure on growth performance, intestinal epithelial histology, appetite‐related hormones and genes expression in broilers

Liver transcriptome response to hyperthermic stress in three distinct chicken lines

Physiology, cell dynamics of small intestinal mucosa, and performance of broiler chickens under heat stress: a review

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