Herein, a facile oneâstep surface modification technique of coating functional biopolymer conjugated musselâinspired catechol (CA) onto substrate is applied to confer polyethersulfone (PES) membranes with remarkable blood compatibility, antifouling property, and antibacterial property, respectively. CA conjugated poly(2âacrylamidoâ2âmethylpropanesulfonic acid) (PAMPS), poly(sulfobetaine methacrylate) (PSBMA), and poly(methacryloxyethyltrimethyl ammonium chloride) are synthesized via free radical polymerization in the presence of CA, and simultaneously coated onto PES membrane surface. The surface chemical compositions, surface zetaâpotential convince the successful preparation of the modified PES membranes. PAMPSâcoated membrane exhibits excellent blood compatibility, especially anticoagulation property; PSBMAâcoated membrane displays excellent antifouling property and blood compatibility; meanwhile, PDMCâcoated membrane shows robust bactericidal property. In general, this work demonstrates that the musselâinspired surface modification protocol provides a facile and versitile method to confer the substrate with excellent blood compatibility, antifouling property, and antibacterial property, respectively, which has great potential for multibiomedical applications, such as blood purification, hemodialysis, and organ implantation.