Consommations problématiques des antalgiques codéinés en automédication : résultats de l’étude DANTE (une Décennie d’ANTalgiques En France)

Guerlais, Marylène; Victorri‐Vigneau, Caroline; Lauzeille, D.; Baumevieille, Marie; Boucher, Alexandra; Chevallier, Claude; Deheul, Sylvie; Eiden, Céline; Fouilhé, Nathalie; Gibaja, Valérie; Boisselier, Reynald Le; Pain, Stéphanie; Pochard, Liselotte; Haramburu, Françoise; Daveluy, Amélie; Roussin, Anne

doi:10.1016/j.therap.2018.09.055

Cited by 2 publications

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“…Diversion of cough syrups in a recreational context has been increasingly described at the international level 6 . In France, scheduling codeine, dextromethorphan, ethylmorphine and noscapine occurred in the contexts of: (i) problematic drug use of codeine tablets indicated as antalgic; and (ii) an expansion of the purple drank phenomenon among adolescents and young adults, in parallel with the reporting of serious intoxications (including 2 deaths in minors in 2017) 7–11 . By contrast, the reclassification of pholcodine occurred earlier in 2011, due to an allergic cross‐reactivity with curare 12 …”

Section: Introductionmentioning

confidence: 99%

“…(ii) an expansion of the purple drank * phenomenon among adolescents and young adults, in parallel with the reporting of serious intoxications (including 2 deaths in minors in 2017). [7][8][9][10][11] By contrast, the reclassification of pholcodine occurred earlier in 2011, due to an allergic cross-reactivity with curare. 12 The French Addictovigilance Network (FAN) has surveyed the diversion of non-prescription drugs (NPD) from the 1990s 13,14 and besides, it has monitored falsified prescription forms for >20 years.…”

Section: Introductionmentioning

confidence: 99%

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Medical prescription forms of opioid cough suppressants falsified by the patients before and after they switched from over‐the‐counter to prescription‐only in France

Jouanjus

Gibaja

Fabre

et al. 2021

Brit J Clinical Pharma

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The French Ministry of Health scheduled opioid cough suppressants as prescription-only drugs on 12 July 2017. The present study assessed the impact of this regulation on the diversion modalities of the concerned drugs and the related drug pholcodine by analysing the national OSIAP (Ordonnances Suspectes Indicateur d'Abus Possible) database. Methods: Medical prescriptions with at least 1 mention of codeine, dextromethorphan, ethylmorphine, noscapine or pholcodine for cough suppression recorded in 2013-2019 were extracted from OSIAP. Annual mentioning rates were estimated by dividing numbers of mentions over those of prescriptions recorded the year considered. A descriptive analysis compared the characteristics of prescriptions before and after 12 July 2017.Results: Overall, 832 mentions of the requested drugs were retrieved on 827 prescription forms. Codeine was the most frequent (n = 809, 8.7%) with 6 additional mentions of codeine/ethylmorphine combination, followed by dextromethorphan (n = 11, 0.1%) and pholcodine (n = 6, 0.1%). There was no mention of noscapine.Annual mentioning rates varied between 0 and 0.3% for all drugs except codeine.Codeine mentioning rates ranged between 0.3% (n = 2) and 0.7% (n = 9) before 12 July 2017 and increased to 10.1% (n = 61) thereafter in 2017, 16.1% (n = 314) in 2018, and 19.8% (n = 414) in 2019. The profile of subjects evolved accordingly with an increased male/female ratio (10.0 vs. 1.5 before) and decreased age (23 vs. 40 y before, P < .001).Discussion: The sharp increase of recourse to falsified prescription forms indicates that codeine diversion continues despite restricted access, whereas the other drugs studied do not seem to have been impacted.

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Section: Introductionmentioning

confidence: 99%