Consolidative mechanisms of emotional processing in REM sleep and PTSD

Murkar, Anthony; Koninck, Joseph De

doi:10.1016/j.smrv.2018.03.001

Cited by 55 publications

(43 citation statements)

References 162 publications

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“…This hypothesis is supported by increased neural activation in affective brain networks during REM sleep, by the replay of the amygdala–hippocampal network, and by experiments that evaluate the sleep processing of negative emotional memories (Ackermann & Rasch, ; Baran, Pace‐Schott, Ericson, & Spencer, ; Genzel, Spoormaker, Konrad, & Dresler, ; Girardeau, Inema, & Buzsáki, ; Hutchison & Rathore, ; Nishida, Pearsall, Buckner, & Walker, ; Van Der Helm et al, ). Accordingly, REM alterations have been described for several neuropsychiatric conditions, such as the posttraumatic stress disorder (Cowdin, Kobayashi, & Mellman, ; Murkar & De Koninck, ) and depression (Agargun & Cartwright, ). Indeed REM sleep alterations have been recently considered not only as a consequence of depression, but as true endophenotypes of the illness (Palagini, Baglioni, Ciapparelli, Gemignani, & Riemann, ).…”

Section: Discussionmentioning

confidence: 99%

Hippocampal oscillatory dynamics and sleep atonia are altered in an animal model of fibromyalgia: Implications in the search for biomarkers

Blasco‐Serra

Alfosea‐Cuadrado

Cervera‐Ferri

et al. 2019

J of Comparative Neurology

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The pathogenesis of fibromyalgia is still unknown. Core symptoms include pain, depression, and sleep disturbances with high comorbidity, suggesting alterations in the monoaminergic system as a common origin of this disease. The reserpine‐induced myalgia (RIM) model lowers pain thresholds and produces depressive‐like symptoms. The present work aims to evaluate temporal dynamics in the oscillatory profiles and motor activity during sleep in this model and to evaluate if the model mimics the sleep disorders that occur in fibromyalgia patients. Hippocampal and electromyogram activity were recorded in chronically implanted rats. Following 3 days of basal recordings, reserpine was administered on three consecutive days to achieve the RIM. Postreserpine recordings were taken on alternate days for 21 days. Reserpine induced changes in the sleep architecture with more transitions between states, and a different pattern between the administration period and postreserpine weeks. Administration days were characterized by a larger amount of rapid eyes movement sleep with dominant theta waves without atonia. Following the reserpinization, theta oscillations were always more fragmented and with lower frequency. On the postreserpine days, sleep was dominated by slow‐wave sleep with fast intrusions and reduced hierarchical coupling with spindles and ripples. Simultaneous electromyography recordings also showed muscle twitches during sleep and the dissociation of theta activity and muscle atonia. Abnormally high slow waves, alpha/delta intrusions, frequent transitions, and muscle twitches are common traits in fibromyalgia. Therefore, our analyses support the validity of the RIM model to study sleep disorders in fibromyalgia, and provide new insights into the research of oscillographic biomarkers.

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Section: Discussionmentioning

confidence: 99%

Hippocampal oscillatory dynamics and sleep atonia are altered in an animal model of fibromyalgia: Implications in the search for biomarkers

Blasco‐Serra

Alfosea‐Cuadrado

Cervera‐Ferri

et al. 2019

J of Comparative Neurology

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“…5,6 Obstructive Sleep Apnea Airway collapses during the sleep cycle, preventing normal breathing, causing lack of oxygen to the brain, preventing the individual from reaching deep sleep along with body and brain repair. 1,5,6,13,14 Poor memory processing, poor emotion processing [2][3][4][5][6]9,12,37 out of the deep stages of sleep, they are prevented from obtaining rejuvenation of the body and brain needed to achieve or maintain optimal health. 1,2 Sleep arousals can be caused by poor sleep hygiene, restricted airway, systemic health issues, or cognitive health issues.…”

Section: Circadian Rhythm Disruptionsmentioning

confidence: 99%

“…1,2 Often, manifestations of poor sleep are misinterpreted as behavioral issues, cognitive dysfunction, and/or systemic health concerns that may present differently in children and adults. 1,3,4 The National Sleep Foundation estimates that 50 to 70 million Americans are affected by chronic sleep disorders or sleep disruptions that can significantly affect health and safety. 5 The Centers for Disease Control and Prevention (CDC) has declared sleep deprivation a public health crisis.…”

mentioning

confidence: 99%

Recognizing Poor Sleep Quality Factors During Oral Health Evaluations

Schroeder

Gurenlian

2019

Clin Med Res

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Oral health practitioners routinely perform oral health assessments for the dental patient to determine if oral disease is present. Systemic health is often a contributor to oral health concerns. One area in particular that has a direct effect on oral structures and oral health is poor sleep quality and open mouth breathing. Sleep is a fundamental process of the human body, which regulates core biological functions. Sleep quality reflects a person's ability to fall asleep, stay asleep, and enter into the various rejuvenating sleep cycles for the full duration. A person who does not obtain quality sleep can exhibit a wide range of oral, systemic, and cognitive health problems. Obstructive sleep apnea, which historically has been considered an adult male disease, is being recognized more often in women children. Research suggests various oral malformations found in newborns and young children can manifest as obstructive sleep apnea in adults. Oral health professionals are in a position to recognize the relationship between sleep and health, identify sleep quality concerns in relation to oral health assessments, administer sleep quality assessments, and determine appropriate referrals for further sleep quality evaluation.

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“…These findings suggest that ongoing seizures may suppress REM sleep, with possible adverse effects on the plastic and cognitive functions that depend upon this state. They also suggest that to better understand the cognitive deficits seen in epilepsy, we require a greater understanding of the mechanisms underlying REM‐related learning …”

Section: Sleep In Children With Epilepsy: Disrupted and Intact Aspectsmentioning

confidence: 99%

“…They also suggest that to better understand the cognitive deficits seen in epilepsy, we require a greater understanding of the mechanisms underlying REM-related learning. 25…”

Section: Influence Of Seizuresmentioning

confidence: 99%

Sleep architecture and homeostasis in children with epilepsy: a neurodevelopmental perspective

Chan¹

2019

Develop Med Child Neuro

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Although the influence of sleep on epilepsy has long been recognized, this relationship has yet to be fully exploited to benefit patients. The past decade has seen significant advances in understanding paediatric sleep, providing a framework by which to properly evaluate the sleep of children with epilepsy, which itself has been subject to increasing scrutiny. The role of sleep in learning and the potential for interictal discharges to disrupt sleep‐related memory consolidation provide a novel perspective for understanding the association of childhood epilepsy with a high rate of intellectual disability. In this review, I outline the evolution of sleep duration, architecture, and homeostasis across childhood, relating this to the development of cognitive functions. I describe how these may be disrupted or preserved in children with epilepsy; in particular, collating data from polysomnography. Finally, I explore how sleep may, in the future, be modulated to improve cognitive outcome in these patients. What this paper adds Children with epilepsy have less rapid eye movement sleep than controls, but this improves with seizure cessation. Deep or slow‐wave sleep is highly conserved in children with epilepsy. Sleep homeostasis may be disrupted either at a local or global level by the presence of interictal epileptiform discharges.

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Consolidative mechanisms of emotional processing in REM sleep and PTSD

Cited by 55 publications

References 162 publications

Hippocampal oscillatory dynamics and sleep atonia are altered in an animal model of fibromyalgia: Implications in the search for biomarkers

Hippocampal oscillatory dynamics and sleep atonia are altered in an animal model of fibromyalgia: Implications in the search for biomarkers

Recognizing Poor Sleep Quality Factors During Oral Health Evaluations

Sleep architecture and homeostasis in children with epilepsy: a neurodevelopmental perspective

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