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Organic by‐product and waste streams generated from agriculture and food production are important future feedstocks for manufacturing chemicals, polymers, and other materials in a circular bioeconomy. These waste streams are currently underutilized and under‐explored in the context of biomanufacturing though much funding and infrastructure have been made available for their use in energy generation. The natural ability of microorganisms to utilize compounds in organic wastes, coupled with advances in engineering biology that enable scientists to manipulate biological systems to produce chemicals, polymers, and materials, and improve upon those processes, present a promising technological approach to the utilization of these waste streams as feedstocks. However, the characteristics of waste streams make them challenging to incorporate into biomanufacturing processes. These challenges can be addressed with additional advances in engineering biology research and thoughtful approaches to process development. Research and process development around the use of existing, localized waste streams present distinct benefits and raise interesting considerations, and are important undertakings. These activities will be as complex as the waste streams targeted; as such, coordination of efforts across relevant agencies and organizations, and collaborations between researchers, waste generators, customers, and other stakeholders will be critical to their success. To make meaningful and rapid contributions towards utilization of organic wastes as biomanufacturing feedstocks we recommend: (1) The National Institute of Food and Agriculture (NIFA) at the US Department of Agriculture should incorporate into existing programs the development of organic waste conversion into chemicals, polymers, and other materials using engineering biology and, if possible, establish new programs focused on this area; and (2) NIFA should oversee, coordinate, and publicize collaborative efforts that include federal agencies, state and regional agricultural research centers and cooperatives, and program‐related infrastructure.
Organic by‐product and waste streams generated from agriculture and food production are important future feedstocks for manufacturing chemicals, polymers, and other materials in a circular bioeconomy. These waste streams are currently underutilized and under‐explored in the context of biomanufacturing though much funding and infrastructure have been made available for their use in energy generation. The natural ability of microorganisms to utilize compounds in organic wastes, coupled with advances in engineering biology that enable scientists to manipulate biological systems to produce chemicals, polymers, and materials, and improve upon those processes, present a promising technological approach to the utilization of these waste streams as feedstocks. However, the characteristics of waste streams make them challenging to incorporate into biomanufacturing processes. These challenges can be addressed with additional advances in engineering biology research and thoughtful approaches to process development. Research and process development around the use of existing, localized waste streams present distinct benefits and raise interesting considerations, and are important undertakings. These activities will be as complex as the waste streams targeted; as such, coordination of efforts across relevant agencies and organizations, and collaborations between researchers, waste generators, customers, and other stakeholders will be critical to their success. To make meaningful and rapid contributions towards utilization of organic wastes as biomanufacturing feedstocks we recommend: (1) The National Institute of Food and Agriculture (NIFA) at the US Department of Agriculture should incorporate into existing programs the development of organic waste conversion into chemicals, polymers, and other materials using engineering biology and, if possible, establish new programs focused on this area; and (2) NIFA should oversee, coordinate, and publicize collaborative efforts that include federal agencies, state and regional agricultural research centers and cooperatives, and program‐related infrastructure.
Glycosidic osmolytes are widespread natural compounds that protect microorganisms and their macromolecules from the deleterious effects of various environmental stresses. Their protective properties have attracted considerable interest for industrial applications, especially as active ingredients in cosmetics and healthcare products. In that regard, the osmolyte glucosylglycerate is somewhat overlooked. Glucosylglycerate is typically accumulated by certain organisms when they are exposed to high salinity and nitrogen starvation, and its potent stabilizing effects have been demonstrated in vitro. However, the applications of this osmolyte have not been thoroughly explored due to the lack of a cost-efficient production process. Here, we present an overview of the progress that has been made in developing promising strategies for the synthesis of glucosylglycerate and its precursor glycerate, and discuss the remaining challenges. Key points • Bacterial milking could be explored for fermentative production of glucosylglycerate • Glycoside phosphorylases of GH13_18 represent attractive alternatives for biocatalytic production • Conversion of glycerol with alditol oxidase is a promising strategy for generating the precursor glycerate
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