Consistent ART Adherence Is Associated with Improved Quality of Life, CD4 Counts, and Reduced Hospital Costs in Central China

Abstract

This study aimed to assess levels of ART adherence and to examine the relationship between adherence and treatment outcomes. A longitudinal study in Hunan and Hubei provinces used the CPCRA Antiretroviral Medication Self-Report and a 7-day Visual Analogue Scale to assess levels of adherence, while quality of life was evaluated using SF-36. CD4 cell count and the number, duration, and cost of hospitalizations were collected from participant medical records. Measurements were obtained at baseline, month 3, and month 6. A total of 113 participants enrolled and 98 completed the study. The mean level of adherence was 91%, 89%, and 88% at baseline and at 3 and 6 months, respectively. Of participants, 54=98 (58%) reported taking all doses at all three interviews and were classified as consistent adherers (CA). CAs had better physical function ( p ¼ 0.001), general health ( p ¼ 0.009), vitality ( p ¼ 0.016), social functioning ( p ¼ 0.001), and mental health ( p ¼ 0.023), and presented a higher CD4 cell count ( p ¼ 0.028). CAs also had fewer hospital admissions and readmissions ( p ¼ 0.005), shorter hospital stays ( p ¼ 0.005), and lower hospital expenses ( p ¼ 0.006). Consistent adherence is associated with better outcomes including improved quality of life, higher CD4 counts, and lower health care costs.

Antiretroviral treatment adherence and associated factors among people living with HIV in developing country, Myanmar

“…1 Although the clinical outcomes of HIV infected patients have been improved by ART, maintaining an optimal adherence to ART is a great challenge. 2 Moreover, adverse effects of ART, complexity of the dosing and socio-economic factors also contribute the challenges to the patients and often influence the ART adherence. 3 Optimal adherence to ART suppresses the viral replication and less likelihood of transmission of HIV to uninfected persons.…”

Hubungan Kepatuhan Anti Retroviral Therapy (Art) Satu Bulan Terakhir Dengan Kualitas Hidup Pasien Hiv/Aids Di Rsud Dr. Soetomo Surabaya

“…Sari, et al (2013) karena kepatuhan ART memperbaiki imunitas, mengendalikan viral load dan menunda progresi penyakit (Silva, et al, 2014). Kepatuhan ART tinggi berhubungan dengan kualitas hidup pasien dalam bidang kesehatan fi sik karena kontribusinya pada peningkatan jumlah CD4 secara pesat (Wang, et al, 2009). Kepatuhan ART rendah berhubungan dengan kualitas hidup pasien dalam bidang kesehatan fi sik karena asupan obat antiretroviral yang bertambah.…”

“…Kepatuhan ART berhubungan dengan kualitas hidup pasien HIV/AIDS dalam bidang lingkungan di mana kepatuhan ART tinggi berhubungan dengan berkurangnya biaya rumah sakit (Wang, et al, 2009) dan kepatuhan ART rendah berhubungan dengan tingkat edukasi yang rendah dan pengangguran (Sarna, et al, 2008).…”

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“…Thus, we may only speculate that the differences in adherence could be because the population of the PLWHA on ART visiting Nyimba ART site is larger (4005) than that of Monze ART site (3251) [38,39]. This suggests that more (200, 55%) participants from Nyimba ART clinic site were included into the study compared to (164, 45%) from Monze ART clinic site.…”

“…It was further noted the mental disorders were highest among the age 50-64 group with 18-34 experiencing higher levels of severe disorders as compared to [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49]. Since most individuals with alcohol problems initiate drinking during adolescence, a period when not only the body is changing dramatically, but behavioural, cognitive, emotional, and attitudinal changes also take place (Dawson, 2000; Grant et al, 2006; Maggs and Schulenberg, 2005; Semlitz & Gold, 1986).…”