Consistency of radiologists in identifying pulmonary nodules based on low-dose computed tomography

Ming, Shuai; Yang, Wei; Cui, Shuai; Huang, Shuai; Gong, Xiangyang

doi:10.21037/jtd.2019.07.52

J. Thorac. Dis

2019

DOI: 10.21037/jtd.2019.07.52

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Consistency of radiologists in identifying pulmonary nodules based on low-dose computed tomography

Shuai Ming

Wei Yang

Shuai Cui

et al.

Abstract: cancer within a period of 2 years (2). Lung cancer accounted for 17.1% of all newly diagnosed cancer cases 21.7% of all cancer-related mortality in China (3). Therefore, early screening and treatment became a top priority for lung cancer (4). The experience of radiologists plays a major role in the detection and correct categorization of the pulmonary nodules on screening LDCT (5). Although, there have many guidelines for reporting of pulmonary nodules, radiologists still have a huge difference

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2024

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Validation of a commercially available CAD-system for lung nodule detection and characterization using CT-scans

Paramasamy,

Mandal,

Blomjous

et al. 2024

Eur Radiol

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Objectives This study aims to externally validate a commercially available Computer-Aided Detection (CAD)-system for the automatic detection and characterization of solid, part-solid, and ground-glass lung nodules (LN) on CT scans. Methods This retrospective study encompasses 263 chest CT scans performed between January 2020 and December 2021 at a Dutch university hospital. All scans were read by a radiologist (R1) and compared with the initial radiology report. Conflicting scans were assessed by an adjudicating radiologist (R2). All scans were also processed by CAD. The standalone performance of CAD in terms of sensitivity and false-positive (FP)-rate for detection was calculated together with the sensitivity for characterization, including texture, calcification, speculation, and location. The R1’s detection sensitivity was also assessed. Results A total of 183 true nodules were identified in 121 nodule-containing scans (142 non-nodule-containing scans), of which R1 identified 165/183 (90.2%). CAD detected 149 nodules, of which 12 were not identified by R1, achieving a sensitivity of 149/183 (81.4%) with an FP-rate of 49/121 (0.405). CAD’s detection sensitivity for solid, part-solid, and ground-glass LNs was 82/94 (87.2%), 42/47 (89.4%), and 25/42 (59.5%), respectively. The classification accuracy for solid, part-solid, and ground-glass LNs was 81/82 (98.8%), 16/42 (38.1%), and 18/25 (72.0%), respectively. Additionally, CAD demonstrated overall classification accuracies of 137/149 (91.9%), 123/149 (82.6%), and 141/149 (94.6%) for calcification, spiculation, and location, respectively. Conclusions Although the overall detection rate of this system slightly lags behind that of a radiologist, CAD is capable of detecting different LNs and thereby has the potential to enhance a reader’s detection rate. While promising characterization performances are obtained, the tool’s performance in terms of texture classification remains a subject of concern. Clinical relevance statement Numerous lung nodule computer-aided detection-systems are commercially available, with some of them solely being externally validated based on their detection performance on solid nodules. We encourage researchers to assess performances by incorporating all relevant characteristics, including part-solid and ground-glass nodules. Key Points Few computer-aided detection (CAD) systems are externally validated for automatic detection and characterization of lung nodules. A detection sensitivity of 81.4% and an overall texture classification sensitivity of 77.2% were measured utilizing CAD. CAD has the potential to increase single reader detection rate, however, improvement in texture classification is required. Graphical Abstract

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Validation of a commercially available CAD-system for lung nodule detection and characterization using CT-scans

Paramasamy,

Mandal,

Blomjous

et al. 2024

Eur Radiol

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Consistency of radiologists in identifying pulmonary nodules based on low-dose computed tomography

Cited by 1 publication

References 27 publications

Validation of a commercially available CAD-system for lung nodule detection and characterization using CT-scans

Validation of a commercially available CAD-system for lung nodule detection and characterization using CT-scans

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