Consistency of Clinical Diagnosis of Dementia in NEDICES: A Population-Based Longitudinal Study in Spain

Abstract

The diagnosis of dementia was highly accurate in this population-based, Spanish cohort study, and our prevalence figures agree with other European surveys. Given the high cost and difficulties of population rescreening and its relatively low yield, we conclude that a single 2-phase investigation (screening followed by clinical examination) provides accurate information for most population-based prevalence studies of dementia.

Statins and Cognitive Functioning in the Elderly: A Population-Based Study

“…Second, we only included people aged 65 and older; the NEDICES study, in which this study was nested, was a study of the elderly (age 65 years and older). However, the study of the relationship statins-cognition in elderly people is of special interest, since prevalence and incidence of cognitive problems is higher in this age group anyway [21,22]. Third, we used a relatively restricted neuropsychological test battery that did not sample all cognitive domains.…”

“…More specifically, the 37-MMSE was adopted to Chilean, Maltese, and Spanish socio-cultural backgrounds and then validated against clinical diagnoses of dementia [21,22,[30][31][32][33]. The 37-MMSE included all of the standard MMSE [30] items as well as three additional items: 1) an attention task, i.e., say 1, 3, 5, 7, 9 backwards; 2) a visual order, i.e., a man raising his arms; and 3) a simple construction task, i.e., copying two overlapping circles [21,22,[30][31][32][33].…”

“…Data for these analyses were derived from the Neurological Disorders in Central Spain (NEDICES) study, a longitudinal, population-based survey of the prevalence, incidence, and determinants of major ageassociated conditions of the elderly, including Parkinson's disease, essential tremor, stroke, and dementia [16][17][18][19][20][21][22][23][24][25]. Detailed accounts of the study population and sampling methods have been published [23][24][25].…”

Long sleep duration in elders without dementia increases risk of dementia mortality (NEDICES)

“…Data were derived from the NEDICES Study, a longitudinal, population-based survey of the epidemiology of major age-associated conditions of the elderly, including Parkinson disease, essential tremor, stroke, and dementia. [10][11][12][13][14][15][16][17][18][19][20] A detailed account of the NEDICES study population and sampling methods has been published. [21][22][23] The survey area consisted of 3 communities: (1) Las Margaritas (approximately 14,800 inhabitants), a working-class neighborhood in Getafe (Greater Madrid); (2) Lista (approximately 150,000 inhabitants), a professional-class neighborhood in the Salamanca district (Central Madrid); and (3) Arévalo (approximately 9,000 inhabitants), an agricultural zone of Arévalo County (located 125 km northwest of Madrid).…”

“…To address this question, we utilized data from the Neurological Disorders in Central Spain (NEDICES) Study, in which participants were followed for a median of 12.5 years, after which the death certificates of those who died were examined. [10][11][12][13][14][15][16][17][18][19][20] METHODS Study population. Data were derived from the NEDICES Study, a longitudinal, population-based survey of the epidemiology of major age-associated conditions of the elderly, including Parkinson disease, essential tremor, stroke, and dementia.…”