Considerations on the contribution of ageing to loss of periodontal tissue support

Papapanou, Panos N.; Lindhe, Jan; Sterrett, John D.; Eneroth, L

doi:10.1111/j.1600-051x.1991.tb00098.x

Cited by 93 publications

(57 citation statements)

References 11 publications

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“…There is evidence that both the prevalence and severity of periodontitis increase with increasing age (Borrell and Papapanou, 2005). However, this age effect can conceivably represent the cumulative effect of prolonged exposure to other risk factors (Papapanou et al, 1991). Smoking has been established as an important risk factor for periodontitis (Genco, 1996;Kornman et al, 1997;Bergstrom, 2004;Kornman, 2005), which is in agreement with our study (OR adjusted ¼ 4.0;.…”

Section: Discussionsupporting

confidence: 83%

Lack of Association of a Functional Polymorphism in the Interleukin 8 Gene with Susceptibility to Periodontitis

Kim

Viana

Curtis

et al. 2009

DNA and Cell Biology

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The important inflammatory mediator interleukin-8 (IL-8) is responsible for the migration and activation of neutrophils. The IL8 gene contains a functional single-nucleotide polymorphism (SNP) (rs4073) in its promoter region that may influence the expression of IL-8, and which has been associated with inflammatory diseases. The purpose of this study was to investigate the association of the SNP (rs4073) in the IL8 gene with susceptibility to periodontitis. DNA was extracted from the buccal epithelial cells of 500 individuals (control n ¼ 224 and periodontitis n ¼ 276). Individuals were genotyped for the SNP (rs4073) using sequence-specific primer polymerase chain reaction. Associations between the SNP (rs4073) and subject phenotypes were analyzed using the chisquared test, followed by univariate and multivariate logistic regression modeling. The genotype distributions in both groups were consistent with Hardy-Weinberg equilibrium. Univariate and multivariate analysis showed that age, skin color, and smoking status were associated with periodontitis. No significant differences were found for sex and frequencies of alleles and genotypes between the control and periodontitis groups in the univariate analysis. These findings were replicated in the multivariate analysis. The SNP (rs4073) in the IL8 gene is not associated with susceptibility to periodontitis in Brazilian individuals, even after controlling for covariates.

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Section: Discussionsupporting

confidence: 83%

Lack of Association of a Functional Polymorphism in the Interleukin 8 Gene with Susceptibility to Periodontitis

Kim

Viana

Curtis

et al. 2009

DNA and Cell Biology

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“…Furthermore, it is worth noting that the factors that increase or decrease the prevalence of periodontitis in sheep in different categories of animals, or even between individuals of the same age, remain unknown. For example, in the epidemiology of periodontal diseases in humans, the higher prevalence of these conditions in adults is more likely due to longer exposure times to risk factors and is not related to age (Papapanou et al 1991).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological, clinical and pathological aspects of an outbreak of periodontitis in sheep

et al. 2016

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The objective of this study was to describe the epidemiological, clinical and pathological aspects of an outbreak of periodontitis in sheep that occurred on a rural property in Benevides, in the state of Pará, Brazil. The first clinical signs of this disease in the herdvisible nodular swollen mandible -were observed about one month after the sheep began grazing on a recently renovated Panicum maximum cv. Massai pasture; the animals were also supplemented with elephant grass (Pennisetum purpureum). From the 545 adult Santa Ines, Dorper, Texel and crossbred sheep, 20 (3.7%) showed facial bulging, particularly of the mandible. These 20 sheep, which were generally over 36 months of age, had low body condition scores as well as dull and ruffled coats; many of them had loose or missing pre, upper or lower molars, showed the formation of abscesses and fistulas, exhibited pain upon palpation and had difficulty chewing. In the same herd, the prevalence of periodontal lesions at the premolars and molar teeth was evaluated via post-mortem examination of 39 young and 17 adult sheep. In 51.3% (20/39) of adolescents and in 100% of adults, periodontal lesions were found at least at one tooth of the dental arch, with unilateral or bilateral periodontal lesions at the maxillary and mandibular teeth. Histopathological analysis of 13 sheep revealed pyogranulomatous inflammation. The second and third maxillary premolars were the teeth that were most affected in young animals, whereas the third pre-molar and the molars, of the maxilla and mandible, were most often affected in adults. These lesions led to severe bone destruction, alterations in the dental arch, occlusion, tooth loss and periodontal abscesses. The epidemiological and clinic-pathological characteristics of this periodontitis outbreak, described here for the first time in sheep in Brazil, were similar to those for bovine periodontitis ("cara inchada"). No mesmo rebanho, a prevalência de lesões periodontais nos dentes pré-molares e molares foi avaliada por meio do exame post-mortem em 39 ovinos jovens e 17 adultos. Assim, 51,3% (20/39) dos jovens e todos os adultos apresentavam lesões periodontais em pelo menos um dos dentes da arcada, com ocorrência uni ou bilateral nos maxilares e mandibulares. A análise histopatológica de 13 animais revelou processo inflamatório piogranulomatoso. Os dentes mais afetados nas arcadas dos animais jovens foram os segundo e terceiro pré-molares maxilares. Já nos adultos foram o terceiro pré-molar e os molares, tanto maxilares quanto mandibulares. As lesões causaram severa destruição óssea, alteração na arcada dentária, na oclusão, perda dental e ocorrência de abscessos periodontais. As características epidemiológicas e clínico-patológicas do surto de periodontite em ovinos, aqui descritos originalmente nesta espécie animal no País, assemelham-se às da periodontite bovina ("cara inchada").TERMOS DE INDEXAÇÃO: Doença periodontal, periodontite, epidemiologia, ovinos.

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“…17 It is recognised as a product of disease expe rience throughout life rather than some thing intrinsic with being older. 18 With all studies unanimous that with increased age comes increased disease, older age groups will exhibit more periodontal destruction practically every time.…”

Section: Agementioning

confidence: 99%

Who is at risk? Periodontal disease risk analysis made accessible for the general dental practitioner

2008

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Considerations on the contribution of ageing to loss of periodontal tissue support

Cited by 93 publications

References 11 publications

Lack of Association of a Functional Polymorphism in the Interleukin 8 Gene with Susceptibility to Periodontitis

Lack of Association of a Functional Polymorphism in the Interleukin 8 Gene with Susceptibility to Periodontitis

Epidemiological, clinical and pathological aspects of an outbreak of periodontitis in sheep

Who is at risk? Periodontal disease risk analysis made accessible for the general dental practitioner

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