Considerations in the use of different spirometers in epidemiological studies

Milanzi, Edith B.; Koppelman, Gerard H.; Oldenwening, Marieke; Augustijn, Sonja W.S.; Ruijter, Bernadette Aalders-de; Farenhorst, Martijn P.; Vonk, Judith M.; Tewis, Marjan; Brunekreef, Bert; Gehring, Ulrike

doi:10.1186/s12940-019-0478-2

Cited by 19 publications

(17 citation statements)

References 23 publications

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“…Third, we included patients that were assessed with two different types of spirometers, resulting in potential systematic differences between lung function measurements. 30 Finally, the interval between PFTs varied. In Korea, the national health insurance covers almost all Koreans, allowing patients to use medical services frequently and quickly.…”

Section: Discussionmentioning

confidence: 99%

FEF25-75% Values in Patients with Normal Lung Function Can Predict the Development of Chronic Obstructive Pulmonary Disease

Kwon¹,

Choi²,

Kim³

et al. 2020

COPD

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Purpose The forced mid-expiratory flow (FEF 25-75% ) value is a potentially sensitive marker of obstructive peripheral airflow. We aimed to assess whether FEF 25-75% can be an early predictor of chronic obstructive pulmonary disease (COPD). Patients and Methods Between July 1, 2007 and June 31, 2009, we identified 3624 patients who underwent a pulmonary function test (PFT) in Gangnam Severance Hospital. We selected 307 patients aged over 40 years without COPD who had normal PFT results at baseline and who had follow-up PFT records more than 1 year later. A FEF 25-75% z-score less than −0.8435 was considered low. We defined COPD as a forced expiratory volume in one second/forced vital capacity value of less than 0.7 before July 31, 2019. Results Among 307 patients, 91 (29.6%) had low FEF 25-75% at baseline. After 10 years, the incidence rate of COPD in the low FEF 25-75% group was significantly higher than that in the normal FEF 25-75% group (41.8% vs 7.4%; P-value <0.001). The Cox proportional hazard model showed that age (hazard ratio [HR] 1.09; P -value<0.001), smoking status (occasional smoker HR, 4.59; P -value<0.001 and long-term smoker HR, 2.18; P -value=0.023), and low FEF 25-75% (HR, 3.31; P -value<0.001) were predictive factors for the development of COPD. Conclusion The FEF 25-75% value in patients with normal lung function is a useful predictor for the development of COPD. We should carefully monitor patients who present with low FEF 25-75% values, even if they have normal lung function.

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Section: Discussionmentioning

confidence: 99%

FEF25-75% Values in Patients with Normal Lung Function Can Predict the Development of Chronic Obstructive Pulmonary Disease

Kwon¹,

Choi²,

Kim³

et al. 2020

COPD

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“…The 16-year lung function measurements were performed using two different spirometers in two different centres for logistical reasons. We performed a comparison study in healthy volunteers using the two spirometers to establish a calibration equation which we used to correct for systematic differences 49. We observed very high correlation between measurements from the two spirometers (0.98–0.99); moreover, we do not expect exposure patterns to be different for measurements performed by either of the spirometers so that effect of using different spirometers is likely very small.…”

Section: Discussionmentioning

confidence: 97%

Timing of secondhand smoke, pet, dampness or mould exposure and lung function in adolescence

Milanzi

Koppelman

Smit

et al. 2019

Thorax

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BackgroundThe relevance of timing of exposure in the associations of secondhand tobacco smoke (SHS), pets, and dampness or mould exposure with lung function is unclear. We investigated the relevance of timing of these exposures for lung function in adolescence.MethodsWe used data from participants of the Dutch Prevention and Incidence of Asthma and Mite Allergy (PIAMA) cohort with spirometric measurements at ages 12 and 16 years (n=552). Data on residential exposure to SHS, pets, and dampness or mould were obtained by repeated parental questionnaires. We characterised timing of exposure through longitudinal patterns using latent class growth modelling and assessed associations of these patterns with FEV1 and FVC at ages 12 and 16 and FEV1 and FVC growth between ages 12 and 16 using linear regression models.ResultsChildhood SHS exposure was associated with reduced FEV1 growth/year (95% CI) (−0.34% (−0.64% to −0.04%)). Late childhood and early life pet exposure was associated with increased FEV1 growth (0.41% (0.14% to 0.67%)) and reduced FVC growth (−0.28% (−0.53% to −0.03%)), respectively, compared with very low exposure. Early life dampness or mould exposure was associated with reduced lung function growth. All time windows of SHS exposure tended to be associated with lower attained lung function and pet exposure tended to be associated with higher FEV1.ConclusionSHS exposure during childhood could lead to reduced lung function growth and lower attained lung function in adolescence. While pet exposure in late childhood may not adversely affect lung function, early childhood pet exposure may slow down FVC growth in adolescence.

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“…Seventeen spirometric indicators were registered by spirometric tests. Of these, three were analyzed in the present study: forced expiratory volume for 1 s (FEV1), forced vital capacity (FVC) and their percentage FEV1/ FVC (Tiffeneau index) [5,6].…”

Section: Methodsmentioning

confidence: 99%

Study of Some Physiological Indicators of the Respiratory System and Related Anthropometric Data in Persons Training for Marine Professionals

Stavrev¹,

Nikolova²,

Doncheva³

et al. 2021

JofIMAB

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The normal functioning of the respiratory system is a leading factor, both for the survival of people caught in an aquatic environment in a marine casualty and for the effectiveness of the assistance activities. In view of this, in 2020 a team of researchers from Varna Medical University, the Naval Academy Varna and the Bulgarian Red Cross set out to study some physiological respiratory parameters and related anthropometric data of 51 individuals, 41 men and 10 women aged between 17 and 48 years of age. The subjects were divided into two groups: 1) trainees in the water rescue courses conducted at BRC-Varna and 2) 1st - year students of the Naval Academy. All participants in the study are non-smokers. The examination of the respiratory indicators is performed according to a standardized methodology with the same spirometer, which is able to measure and register over 30 indicators. Of these, three were analyzed in the present study: forced expiratory volume for 1 s (FEV1), forced vital capacity (FVC), and their FEV1/FVC percentage (Tiffeneau index). The results show that, according to anthropometric data, FVC and FEV1 are higher in water rescue trainees than in Naval Academy cadets. The Tiffeneau index is higher than the reference values of the participants in both study groups, but the results are better in the group of naval cadets. As far as the functional capabilities of the respiratory system are essential for the activity of marine professionals, it can be assumed that the high results obtained from the spirometric examination of the participants from both groups are a prerequisite for higher efficiency of rescue operations and improvement of their personal safety. when working in a marine environment. The prospect is that after collecting a statistically significant amount of data combined with results obtained from other types of functional tests, to create better safety practices for people who are professionally engaged in maritime activities. As far as the functional capabilities of the respiratory system are essential for the activity of marine professionals, it can be assumed that the high results of the spirometric study in all study participants are a prerequisite for improving both their personal safety when working in the marine environment and for higher efficiency and success of rescue operations. The perspective is, after collecting a statistically significant volume of data and in combination with other functional studies, to create good practices to improve the safety systems of people in contact with the marine environment .

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Considerations in the use of different spirometers in epidemiological studies

Cited by 19 publications

References 23 publications

<p>FEF<sub>25-75%</sub> Values in Patients with Normal Lung Function Can Predict the Development of Chronic Obstructive Pulmonary Disease</p>

<p>FEF<sub>25-75%</sub> Values in Patients with Normal Lung Function Can Predict the Development of Chronic Obstructive Pulmonary Disease</p>

Timing of secondhand smoke, pet, dampness or mould exposure and lung function in adolescence

Study of Some Physiological Indicators of the Respiratory System and Related Anthropometric Data in Persons Training for Marine Professionals

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