Considerations in evaluating new treatment alternatives following peripheral nerve injuries: A prospective clinical study of methods used to investigate sensory, motor and functional recovery

Åberg, Maria; Ljungberg, Christina; Edin, E; Jenmalm, Per; Millqvist, H; Nordh, Erik; Wiberg, Mikael

doi:10.1016/j.bjps.2006.04.019

Cited by 31 publications

(20 citation statements)

References 54 publications

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“…The data presented suggest that by specifically assessing neuron death, volumetric MRI has evident potential for the clinical study of neuroprotective agents in contrast to current inadequate sensory outcome measures that lack sensitivity and specificity. [12][13][14] The discriminatory power of volumetric MRI and its ability to reflect change (responsiveness) must now be established through the analysis of different injury patterns and postinjury time points. This study was designed to optimize detection of DRG volume loss by scanning patients at a sufficient time interval post-injury that neuron loss was complete and thus maximal.…”

Section: Neuron Death and The Neuroprotective Benefit Of Nerve Repairmentioning

confidence: 99%

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Sensory Neuron Death After Upper Limb Nerve Injury and Protective Effect of Repair

et al. 2013

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MRI provides noninvasive in vivo assessment of DRG volume as a proxy clinical measure of sensory neuron death. The significant decrease found after unrepaired nerve injury provides indirect clinical evidence of axotomy-induced neuronal death. This loss was less after nerve repair, indicating a neuroprotective benefit of early repair. Volumetric MRI has potential diagnostic applications and is a quantitative tool for clinical trials of neuroprotective therapies.

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Section: Neuron Death and The Neuroprotective Benefit Of Nerve Repairmentioning

confidence: 99%

“…Current sensory outcome measures lack requisite sensitivity, and none specifically address the significant issue of neuron death. [12][13][14] Hence a new tool is designed for assessing neuron death in vivo.…”

mentioning

confidence: 99%

Sensory Neuron Death After Upper Limb Nerve Injury and Protective Effect of Repair

et al. 2013

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“…Aberg et al presented a method for clinical evaluation following peripheral nerve injury. 59 They investigated the applicability of a battery of clinical tests in a small sample consisting of 15 patients with median nerve injuries and 15 control subjects. The tests in this clinical assessment were sensory recovery (two-point discrimination, cutaneous pressure thresholds, pin prick, thermal thresholds, sensory nerve conduction velocity and amplitude), motor recovery (manual muscle testing, grip and pinch strength, motor nerve conduction velocity and amplitude, needle electromyography), and functional recovery (four questions about function, pain, cold intolerance and dysaesthesia; DASH; motor performance test; Sollerman hand function test; sensorimotor test).…”

Section: Outcome Measuresmentioning

confidence: 99%

Neuropathic Pain in Patients with Upper-Extremity Nerve Injury

Novak

Katz²

2010

Physiotherapy Canada

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Purpose: The purpose of this review was to present an analysis of the literature of the outcome studies reported in patients following traumatic upperextremity (UE) nerve injuries (excluding amputation), to assess the presence of an association between neuropathic pain and outcome in patients following traumatic UE nerve injuries, and to provide recommendations for inclusion of more comprehensive outcome measures by clinicians who treat these patients. Summary of Key Points: A Medline and CINAHL literature search retrieved 48 articles. This review identified very few studies of patients with peripheral nerve injury that reported neuropathic pain. When pain was reported, visual analogue or numeric rating scales were most frequently used; standardized questionnaires measuring pain or psychosocial function were rarely administered. Recent evidence shows substantial long-term disability and pain in patients following peripheral nerve injury. Recommendation: To better understand neuropathic pain in patients following peripheral nerve injury, future outcome studies should include valid, reliable measures of physical impairment, pain, disability, health-related quality of life, and psychosocial functioning.Key Words: literature review, nerve injury, neuropathic pain, outcome Novak CB, Katz J. Neuropathic pain in patients with upper-extremity nerve injury. Physiother Can. 2010;62:190-201. RÉ SUMÉObjectif : L'objectif de cette revue é tait de pré senter une analyse de la documentation portant sur les é tudes ré pertorié es concernant les patients aux prises avec des lé sions nerveuses traumatiques des membres supé rieurs (excluant l'amputation), d'é valuer la pré sence d'un lien entre la douleur né vropathique et les ré sultats attendus chez les patients à la suite de lé sions nerveuses traumatiques des membres supé rieurs et de formuler des recommandations en vue d'inclure le recours à des mesures de rendement plus complè tes par les cliniciens traitant ces patients. Ré sumé des principales é tapes : Une recherche documentaire dans Medline et dans CINAHL a permis de ré pertorier 48 articles. Cette recherche a permis de constater que parmi les patients souffrant de lé sions nerveuses pé riphé riques é tudié s, trè s peu avaient signalé des douleurs né vropathiques. Lorsque de la douleur é tait signalé e, des é chelles de mesure numé riques ou des é chelles visuelles analogues é taient utilisé es le plus fré quemment et l'on faisait rarement appel à des questionnaires normalisé s pour é valuer la douleur ou la fonction psychosociale. Des faits ré cents dé montrent qu'à la suite d'une lé sion nerveuse pé riphé rique, de nombreux patients ressentent de la douleur et souffrent d'une incapacité à long terme. Recommandation : Pour mieux comprendre la douleur né vropathique qui survient à la suite d'une lé sion nerveuse pé riphé rique, les prochaines é tudes devraient inclure des mesures valables et fiables des dé ficiences physiques, de la douleur, des incapacité s, de la qualité de vie lié e à la santé et à la fonctio...

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“…In the current literature on CTS, there is a paucity of validated objective outcome measures for assessing hand functional impairment. Instead, subjective pain questionnaires, patient‐rated functional scales, electrophysiological parameters, and sensory and motor strength tests are commonly used ( Wong et al, 2006 ; Aberg et al, 2007 ; Unglaub et al, 2008 ) . Although those tests are helpful, they cannot substitute for function assessment ( Dellon and Kallman, 1983 ) .…”

Section: Introductionmentioning

confidence: 99%

Discriminative validity and test–retest reliability of the Dellon‐modified Moberg pick‐up test in carpal tunnel syndrome patients

Amirjani

Ashworth

Olson

et al. 2011

J Peripheral Nervous Sys

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There is a scarcity of validated hand performance tests with proven reliability for quantifying functional deficits in patients with carpal tunnel syndrome (CTS). The Dellon-modified Moberg pick-up test (DMMPUT), composed of commonly used daily objects, is potentially well suited for that purpose. This study was designed to evaluate the test-retest reliability and discriminative validity of the DMMPUT in CTS patients. We compared 162 CTS patients with 116 age-matched controls. CTS severity was determined based on electrophysiological parameters and Levine's Self-Assessment Questionnaire. The mean time to complete each subset of the DMMPUT by the CTS patients was compared with that by the healthy subjects. Test-retest reliability was examined in 46 CTS patients. Discriminative validity was demonstrated through a significant difference in test completion time between the CTS subjects and their age-matched controls. With few exceptions, the test scores declined with increasing severity of electrophysiological abnormalities and subjective symptom severity. Test-retest reliability of the DMMPUT was high with an intra-class correlation coefficient of 0.91. The DMMPUT has discriminative validity and high test-retest reliability in patients with CTS. It can be a useful standardized outcome measure to gauge disease severity.

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Considerations in evaluating new treatment alternatives following peripheral nerve injuries: A prospective clinical study of methods used to investigate sensory, motor and functional recovery

Cited by 31 publications

References 54 publications

Sensory Neuron Death After Upper Limb Nerve Injury and Protective Effect of Repair

Sensory Neuron Death After Upper Limb Nerve Injury and Protective Effect of Repair

Neuropathic Pain in Patients with Upper-Extremity Nerve Injury

Discriminative validity and test–retest reliability of the Dellon‐modified Moberg pick‐up test in carpal tunnel syndrome patients

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