Considerations for successful cancer immunotherapy in aged hosts

Hurez, Vincent; Padrón, Álvaro; Svatek, Robert S.; Curiel, Tyler J.

doi:10.1111/cei.12875

Cited by 57 publications

(33 citation statements)

References 115 publications

(149 reference statements)

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“…The most important of these receptors are PD-1, CTLA-4, LAG-3, TIM-3, and TIMIN. This distinction has gained considerable importance since it has been reported that a number of cancers in some elderly subjects could be successfully modulated and T cells engineered to be immunotoxic toward such cancers, namely melanoma and NSCLC ( 80 – 82 ).…”

Section: Immune Changes With Aging: Immunosenescence and Inflamm-aginmentioning

confidence: 99%

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

et al. 2018

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The immune system is the most important protective physiological system of the organism. It has many connections with other systems and is, in fact, often considered as part of the larger neuro–endocrine–immune axis. Most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflamm-aging. Together, immunosenescence and inflamm-aging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of immune-gerontologists have challenged this negative interpretation of immunosenescence with respect to its significance in aging-related alterations of the immune system. If one considers these changes from an evolutionary perspective, they can be viewed preferably as adaptive or remodeling rather than solely detrimental. Whereas it is conceivable that global immune changes may lead to various diseases, it is also obvious that these changes may be needed for extended survival/longevity. Recent cumulative data suggest that, without the existence of the immunosenescence/inflamm-aging duo (representing two sides of the same phenomenon), human longevity would be greatly shortened. This review summarizes recent data on the dynamic reassessment of immune changes with aging. Accordingly, attempts to intervene on the aging immune system by targeting its rejuvenation, it may be more suitable to aim to maintain general homeostasis and function by appropriately improving immune-inflammatory-functions.

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Section: Immune Changes With Aging: Immunosenescence and Inflamm-aginmentioning

confidence: 99%

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

et al. 2018

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“…As we dissect components and interactions in more detail, the research enterprise can begin to embrace variation to learn better from animal models [223,224] and humans [225,226] , including with respect to age [227] . Data sharing can help ensure technical advances are employed towards broad evidence-based progress [228] .…”

Section: Monitoring and Modelingmentioning

confidence: 99%

A primer on recent developments in cancer immunotherapy, with a focus on neoantigen vaccines

Tokuyasu¹,

Huang²

2018

JCMT

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Cancer immunotherapy has now been conclusively shown to be capable of producing durable responses for a substantial number of patients. Adoptive cell transfer and checkpoint blockade therapies in particular both demonstrate that antigen-specific immune responses can be dramatically effective, even in previously refractory late stage disease. Such developments, together with advances in technology, have strongly encouraged revisiting the concept of neoantigen vaccines. Here we introduce basic ideas in the field to allow investigators from diverse backgrounds to understand these developments, grasp current issues, and contribute to further progress.

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“…Finally, it is well known that cancer incidence increases with age. Measures of aging in the immune system [294] could potentially be used to predict tumor/immune interactions and guide treatment decisions [295] .…”

Section: Systemic Immune Responsementioning

confidence: 99%

Informatics for Cancer Immunotherapy

Hammerbacher

Charen

2017

Preprint

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Abstract:The rapid development of immunomodulatory cancer therapies has led to a concurrent increase in the application of informatics techniques to the analysis of tumors, the tumor microenvironment, and measures of systemic immunity. In this review, the use of tumors to gather genetic and expression data will first be explored. Next, techniques to assess tumor immunity are reviewed, including HLA status, predicted neoantigens, immune microenvironment deconvolution and T-cell receptor (TCR) sequencing. Attempts to integrate these data are in early stages of development and are discussed next. Finally, we review the application of these informatics strategies to therapy development, with a focus on vaccines, adoptive cell transfer, and checkpoint blockade therapies.

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Considerations for successful cancer immunotherapy in aged hosts

Cited by 57 publications

References 115 publications

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

A primer on recent developments in cancer immunotherapy, with a focus on neoantigen vaccines

Informatics for Cancer Immunotherapy

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