“…While previous reviews have summarized the effects of different EDCs on female reproductive health and the ovary ( Bolden et al, 2017 , Hannon and Flaws, 2015 , Lauretta et al, 2019 , Patel et al, 2015 , Rattan et al, 2017 ), evidence regarding the effects of PAC exposure on mammalian ovarian function is limited. Toxicological studies investigating the endocrine disruptive effects of PACs focus largely on parent PAH compounds and overlooks other classes that are also present in the environment and may be more toxic than their parent/unsubstituted compounds ( Hsieh et al, 2021 , Lam et al, 2018 ; Lee et al, 2017 , Marvin et al, 2020 , Provencher et al, 2020 ). As such, there is an urgent need to consider PACs as a priority environmental contaminant, especially as the risk for exposure continues to grow in parallel with urban/industrial expansion and the global reliance for petroleum products ( Marvin et al, 2020 ).…”