Dr Jeffries); Northwest Pediatric Therapies, Issaquah, Washington (Dr Yocum).Purpose: To highlight key considerations for planning and implementing multisite research based on experiences and reflections in conducting a large, international, multisite study. Description: Successes and challenges encountered throughout a multisite study process, and collective recommendations for future researchers are presented. Considerations addressed include creation of the research team and a "community of practice," study preparation and management time, approval by institutional review boards, training of future researchers, recruitment and retention of participants, and dissemination and translation of study materials to consumers. Importance to Members: Multisite research has the potential to create knowledge for pediatric physical therapy through collaboration among knowledgeable researchers and expert practitioners and by increasing the potential for generalization of findings. Effective planning, including anticipation of challenges, is critical to a successful study. Our collective experiences may assist practitioners and researchers in planning, implementing, and completing future multisite studies. (Pediatr Phys Ther 2010;22:408-416) lows for collaboration of researchers and expert clinicians with varied knowledge, interests, and expertise and completion of studies that are not feasible to conduct at a single site. Multisite studies are needed to meet sample size requirements for research on populations with lower incidences 2 and to improve generalization of findings. Another advantage is the potential to foster collaboration between practitioners and researchers and, as a result, enhance translation of findings into practice.Despite the benefits, multisite studies are complex and require considerable resources, infrastructure, and coordination. Previous articles have described the challenges with multisite research including site coordination, 2 consistency of data collection, 2,3 selection of team members and team leadership, 4 consensus on research procedures, 4 and decisions on authorship. 3,4 The time and effort required to receive institutional review board (IRB) approval