Considerations for continuing diet therapy in patients with epilepsy during the COVID-19 pandemic: A scoping review

Fujimoto, Ayataka

doi:10.1016/j.ebr.2021.100498

Cited by 1 publication

(1 citation statement)

References 19 publications

(42 reference statements)

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“…The 2019 coronavirus disease (COVID-19) pandemic and the associated lock-down measures have certainly affected children with epilepsy, particularly those who are candidates for KD ( 17 ), as a result, inpatient KD initiation has been sharply restricted ( 18 ). Therefore, continuing a specific diet during the COVID-19 pandemic is expected to be difficult in some aspects ( 19 ). Outpatient KD initiation that will result in easier implementation, shorter hospital stays, and reduced medical and family costs would have clinical and economic advantages ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Analysis of the efficacy and safety of inpatient and outpatient initiation of KD for the treatment of pediatric refractory epilepsy using generalized estimating equations

Hao

et al. 2023

Front. Neurol.

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ObjectiveTo compare the efficacy and safety of inpatient and outpatient initiation ketogenic diet (KD) protocol of pediatric refractory epilepsy.MethodsEligible children with refractory epilepsy were randomly assigned to receive KD with inpatient and outpatient initiation. The generalized estimation equation (GEE) model was used to analyze the longitudinal variables of seizure reduction, ketone body, weight, height, body mass index (BMI), and BMI Z-score at different follow-up times between the two groups.ResultsBetween January 2013 and December 2021, 78 and 112 patients were assigned to outpatient and inpatient KD initiation groups, respectively. There were no statistical differences between the two groups based on baseline demographics and clinical characteristics (all Ps > 0.05). The GEE model indicated that the rate of reduction of seizures≥50% in the outpatient initiation group was higher than that of the inpatient initiation group (p = 0.049). A negative correlation was observed between the seizure reduction and blood ketone body at 1, 6, and 12 months (all Ps < 0.05). There were no significant differences in height, weight, BMI, and BMI Z-score between the two groups over the 12-month period by the GEE models (all Ps > 0.05). Adverse events were reported by 31 patients (43.05%) in the outpatient KD initiation group and 46 patients (42.20%) in the inpatient KD initiation group, but these differences were not statistically significant (p = 0.909).ConclusionOur study shows that outpatient KD initiation is a safe and effective treatment for children with refractory epilepsy.

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Section: Introductionmentioning

confidence: 99%

Analysis of the efficacy and safety of inpatient and outpatient initiation of KD for the treatment of pediatric refractory epilepsy using generalized estimating equations

Hao

et al. 2023

Front. Neurol.

View full text Add to dashboard Cite

show abstract

Considerations for continuing diet therapy in patients with epilepsy during the COVID-19 pandemic: A scoping review

Cited by 1 publication

References 19 publications

Analysis of the efficacy and safety of inpatient and outpatient initiation of KD for the treatment of pediatric refractory epilepsy using generalized estimating equations

Analysis of the efficacy and safety of inpatient and outpatient initiation of KD for the treatment of pediatric refractory epilepsy using generalized estimating equations

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