Considerations for application of benchmark dose modeling in radiation research: workshop highlights

Chauhan, Vinita; Yu, Jihang; Vuong, Ngoc Q.; Haber, Lynne T.; Williams, Andrew; Auerbach, Scott S.; Beaton, Danielle; Wang, Yi; Stainforth, R.; Wilkins, Russell; Azzam, Edouard I.; Richardson, Richard B.; Khan, Gulam Musawwir; Jadhav, Ashok; Burtt, Julie; Leblanc, Julie; Randhawa, Kristi; Tollefsen, Knut Erik; Yauk, Carole

doi:10.1080/09553002.2023.2181998

Cited by 4 publications

(2 citation statements)

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“…Benchmark dose (BMD) modeling is a method used in chemical toxicology to determine the point of departure from a dose-response curve associated with a health-related outcome (11). It involves tting mathematical models to dose-response data and identifying the BMD, or its lower bound.…”

Section: Introductionmentioning

confidence: 99%

“…BMD modeling has also been explored in the analysis of transcriptional data for the development of quantitative adverse outcome pathways (12). It has been shown that BMDs derived from molecular endpoints can correlate with apical endpoints of interest for regulatory decisions (11). It is widely used in risk assessment to establish health standards and guidelines for exposure to toxins.…”

Section: Introductionmentioning

confidence: 99%

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Benchmark dose determining airborne crystalline silica particles based on A549 lung-cell line survival in an in vitro study

Rafieepour,

Shekarloo,

Ashtarinezhad

et al. 2024

Preprint

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Crystalline silica has emerged as a prominent occupational toxicant over extended periods, leading to the development of lung fibrosis and cancer. The objective of this investigation is to establish a benchmark dose (BMD) for crystalline silica micro and nanoparticles based on the viability of the A549 lung-cell line. The impact of exposure to crystalline silica micro-particles (C-SiO2 MPs) and crystalline silica nanoparticles (C-SiO2 NPs) on A549 epithelial lung cells was examined for durations of 24 and 72 hours to evaluate cell viability using the MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay. The determination of dose-response and BMD was carried out through the BMD software v 3.2. The findings reveal a dose-dependent relationship between cell viability and both C-SiO2 MPs and -NPs. The BMDL values for 24-h treatment of C-SiO2 MPs and -NPs were determined to be 2.26 and 0.97 µg/ml, respectively, based on exponential models. Correspondingly, these values were found to be 1.17 and 0.85 µg/ml for the 72-h treatment. This investigation underscores the significance of particle size as a contributing factor in assessing occupational health risks. Moreover, the utilization of BMDL can facilitate the determination of more precise values for occupational exposures by considering various parameters associated with particle presence.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%