Considerations concerning interaction characterization of oligopeptide mixtures with vancomycin using affinity capillary electrophoresis-electrospray mass spectrometry

Lynen, Frédéric; Zhao, Yining; Becu, Chr.; Borremans, Frans; Sandra, Pat

doi:10.1002/(sici)1522-2683(19990801)20:12<2462::aid-elps2462>3.0.co;2-5

Cited by 32 publications

(10 citation statements)

References 48 publications

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“…One may predict that the coupling of ACE methods with MS, so far used rarely and only for model studies [112,113], will increase. In complex, multi-component equilibriums, the qualitative identification power of MS will be more important the more partners there are in the complex.…”

Section: Discussionmentioning

confidence: 99%

Determination of binding constants by affinity capillary electrophoresis, electrospray ionization mass spectrometry and phase-distribution methods

Chen

Weber

2008

TrAC Trends in Analytical Chemistry

129

108

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Many methods for determining intermolecular interactions have been described in the literature in the past several decades. Chief among them are methods based on spectroscopic changes, particularly those based on absorption or nuclear magnetic resonance (NMR) [especially proton NMR ( 1 H NMR)]. Recently, there have been put forward several new methods that are particularly adaptable, use very small quantities of material, and do not place severe requirements on the spectroscopic properties of the binding partners. This review covers new developments in affinity capillary electrophoresis, electrospray ionization mass spectrometry (ESI-MS) and phasetransfer methods.

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Section: Discussionmentioning

confidence: 99%

Determination of binding constants by affinity capillary electrophoresis, electrospray ionization mass spectrometry and phase-distribution methods

Chen

Weber

2008

TrAC Trends in Analytical Chemistry

129

108

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“…77,212 Recently, vancomycin was evaluated as the chiral selector for the quantitation of loxiglumide enantiomers, 213 acidic herbicides in groundwater and river water, 214 and for the hyphenation of electrophoretic chiral separations with electrospray mass spectrometry. 215,216 In MEKC with sodium dodecyl sulfate as the micelle-forming constituent, vancomycin resolves a variety of uncharged hydrophobic drugs and pesticides. 192,193 Positively charged vancomycin, recommended for chiral separations, 78,203 adsorbs onto bare fused silica.…”

Section: E Macrocyclic Antibioticsmentioning

confidence: 99%

Chiral Separations in Capillary Electrophoresis

2000

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“…This approach can couple on-line reaction with the separation. Lynen et al [130] [131]. The library components that showed the strongest interaction were identified.…”

Section: Small Molecule-small Molecule Interactionmentioning

confidence: 99%

Recent advances in the study of biomolecular interactions by capillary electrophoresis

Ding

et al. 2004

Electrophoresis

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Recent advances in the study of biomolecular interactions by capillary electrophoresisCapillary electrophoresis (CE) has been abundantly used in the study of molecular interactions owing to such advantages as short analysis time, low sample size requirement, high separation efficiency, and flexible applications. The focus of this paper is to review recent studies and advances (mainly from 1998 to now) in biomolecular interactions using CE. Five CE modes: zone migration CE, affinity CE, frontal analysis (FA), Hummel-Dreyer (HD) and vacancy peak (VP) are cited and compared. Quantitative aspects of the thermodynamics and kinetics of biomolecular interaction are reviewed. Several biomolecular binding systems, including protein-protein (polypeptide), protein-DNA (RNA), protein(polypeptide)-carbohydrate, protein-small molecule, DNAsmall molecule, small molecule-small molecule, have been well characterized by CE. CE is shown to be a powerful tool for the determination of the binding parameters of various bioaffinity interactions.

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Considerations concerning interaction characterization of oligopeptide mixtures with vancomycin using affinity capillary electrophoresis-electrospray mass spectrometry

Cited by 32 publications

References 48 publications

Determination of binding constants by affinity capillary electrophoresis, electrospray ionization mass spectrometry and phase-distribution methods

Determination of binding constants by affinity capillary electrophoresis, electrospray ionization mass spectrometry and phase-distribution methods

Chiral Separations in Capillary Electrophoresis

Recent advances in the study of biomolecular interactions by capillary electrophoresis

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