Considerations and Complications in Patients Undergoing Ileal Pouch Anal Anastomosis

Francone, Todd D.; Champagne, Brad

doi:10.1016/j.suc.2012.09.004

Cited by 48 publications

(30 citation statements)

References 159 publications

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“…The overall IAA leak rate in our UC cohort requiring PPP was 3.55 % (n=71) which is slightly lower than the quoted range in the literature of 5 to 19 % [1][2][3][4]. An IAA leak is the single most important determinant of pouch failure, which can occur in up to 30 % of cases.…”

Section: Discussionmentioning

confidence: 48%

“…An IAA leak is the single most important determinant of pouch failure, which can occur in up to 30 % of cases. Pouch failure can cause significant long-term morbidity including functional deterioration and requirement of subsequent operative intervention(s) [3,15,16]. Determining factors associated with increased risk of post-operative IAA leaks is imperative for patients with UC undergoing elective PPP.…”

Section: Discussionmentioning

confidence: 99%

“…One of the most significant post-operative complications of the PPP is an IAA leak, occurring in 5-19 % of cases [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…Multiple risk factors have been observed as potential contributors to this post-operative complication. These include patient-related factors [3,11,12] (such as male gender, older age, malnutrition, increased body mass index [BMI], steroid use and a diagnosis of Crohn's disease) and operative-related factors [3,11,13] (including transfusion requirement and lack of a de-functioning ileostomy, hand-sewn anastomosis, tension and ischemia at the anastomotic site).…”

Section: Introductionmentioning

confidence: 99%

“…

Purpose The pelvic pouch procedure (PPP) carries significant post-operative complication risks including a 4-14 % risk of ileo-anal anastomotic (IAA) leak [1][2][3][4]. The aim of this study is to evaluate the severity of disease at the distal resection margin as an independent risk factor for an IAA leak following the PPP for patients with ulcerative colitis (UC).

…”

mentioning

confidence: 99%

See 4 more Smart Citations

Severity of inflammation as a risk factor for ileo-anal anastomotic leak after a pouch procedure in ulcerative colitis

Zerhouni

Kirsch

Bakonyi

et al. 2015

Int J Colorectal Dis

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

“…One of the most significant post-operative complications of the PPP is an IAA leak, occurring in 5-19 % of cases [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…

…”

mentioning

confidence: 99%

See 3 more Smart Citations

Severity of inflammation as a risk factor for ileo-anal anastomotic leak after a pouch procedure in ulcerative colitis

Zerhouni

Kirsch

Bakonyi

et al. 2015

Int J Colorectal Dis

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Retrospective investigation of tacrolimus combined with an anti‐tumor necrosis factorα antibody as remission induction therapy for refractory ulcerative colitis: Efficacy, safety, and relapse rate

et al. 2019

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Background and AimCombined therapy with tacrolimus (TAC) and an anti‐tumor necrosis factorα (TNFα) antibody is used to induce remission in ulcerative colitis (UC) patients who have not responded to monotherapy with either drug. We evaluated the efficacy and safety of combined therapy, as well as the relapse rate.MethodsCombined therapy was performed to induce remission in UC patients showing an inadequate response to monotherapy with TAC or an anti‐TNFα antibody. The following items were assessed retrospectively: (i) clinical characteristics, (ii) the remission induction rate, (iii) the relapse rate, and (iv) adverse events.ResultsCombined therapy induced remission in 7 of the 12 patients (58.3%). There were no significant differences in clinical characteristics between the patients with and without the successful induction of remission. However, the number of female patients tended to be higher in the remission group than in the nonremission group. The remission group also showed trends of a lower clinical activity index (Lichtiger index; CAI) on admission and before combined therapy and a lower total dose of prednisolone during hospitalization. The 1‐year relapse rate was 33.3%. Adverse events due to combined therapy included renal impairment (n = 2), tremors (n = 2), influenza (n = 1), and a positive cytomegalovirus antibody test (n = 3). None of these events were serious.ConclusionsCombined therapy was effective in more than half of the patients with refractory UC who had not responded to monotherapy. Our findings suggest that combination therapy may be a new, third option for the treatment of refractory UC.

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Segmental versus extended resection for sporadic colorectal cancer in young patients

Klos

Montenegro

Jamal

et al. 2014

Journal of Surgical Oncology

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Considerations and Complications in Patients Undergoing Ileal Pouch Anal Anastomosis

Cited by 48 publications

References 159 publications

Severity of inflammation as a risk factor for ileo-anal anastomotic leak after a pouch procedure in ulcerative colitis

Severity of inflammation as a risk factor for ileo-anal anastomotic leak after a pouch procedure in ulcerative colitis

Retrospective investigation of tacrolimus combined with an anti‐tumor necrosis factorα antibody as remission induction therapy for refractory ulcerative colitis: Efficacy, safety, and relapse rate

Segmental versus extended resection for sporadic colorectal cancer in young patients

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