Consider dosing, monitoring and complications when using anticoagulants to treat acute venous thromboembolism in paediatric patients

Abstract

Appropriate dosing, routine monitoring and the risks of complications are important considerations when treating acute venous thromboembolism (VTE) in paediatric patients. Due to the lack of high-quality evidence, the use of anticoagulants in paediatric patients is largely based on extrapolation from adult data. Age-dependent differences in haemostasis and drug metabolism, particularly in neonates, makes this approach sub-optimal.