Conserved virulence of C to B capsule switched Neisseria meningitidis clinical isolates belonging to ET-37/ST-11 clonal complex

Lancellotti, Marcelo; Guiyoule, Annie; Ruckly, Corinne; Hong, Eva; Alonso, Jean-Michel; Taha, Muhamed‐Kheir

doi:10.1016/j.micinf.2005.06.012

Cited by 47 publications

(42 citation statements)

References 26 publications

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“…Fine typing has been employed to evaluate the impact of mass anti-serogroup C vaccination on the risk of emergence of escape variants within the ST-11 clonal complex between the pre-and postvaccination periods in France (26). MLST and phenotyping have also been used to help evaluate the impact of serogroup C conjugate vaccines on meningococcal carriage in the United Kingdom (29).…”

Section: Discussionmentioning

confidence: 99%

Clonal Distribution of Disease-Associated and Healthy Carrier Isolates ofNeisseria meningitidisbetween 1983 and 2005 in Cuba

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Clonal Distribution of Disease-Associated and Healthy Carrier Isolates ofNeisseria meningitidisbetween 1983 and 2005 in Cuba

et al. 2010

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“…This relatively high proportion of non C serogroups among isolates belonging to CC ST-11 points to possible capsule switching resulting from selective pressure of the immune response to the Men CC vaccine. 30,31 Capsule switching events have been reported, but no expansion of these events has occurred so far. 32 Several European countries with high incidence rates of meningococcal C disease (UK, Netherlands, Ireland, Spain, etc.)…”

Section: Discussionmentioning

confidence: 99%

Association of Meningococcal Phenotypes and Genotypes With Clinical Characteristics and Mortality of Meningitis in Children

Lévy¹,

Taha²,

Olivier³

et al. 2010

Pediatric Infectious Disease Journal

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“…Horizontal transfer of genes may also result in the lack of association of genotypes or CCs with particular hosts or sources, as host adaptation factors could be transmitted frequently between genomic backgrounds. However, in N. meningitidis, some STs or CCs are known to be associated with specific epidemic or virulence properties (13,37), with important consequences for infection control and vaccination strategies. The MLST system described here should be useful for future investigations of these important public health-related questions in P. shigelloides.…”

Section: Discussionmentioning

confidence: 99%

Recombining Population Structure of Plesiomonas shigelloides ( Enterobacteriaceae ) Revealed by Multilocus Sequence Typing

et al. 2007

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Plesiomonas shigelloides is an emerging pathogen that is widespread in the aquatic environment and is responsible for intestinal diseases and extraintestinal infections in humans and other animals. Virtually nothing is known about its genetic diversity, population structure, and evolution, which severely limits epidemiological control. We addressed these questions by developing a multilocus sequence typing (MLST) system based on five genes (fusA, leuS, pyrG, recG, and rpoB) and analyzing 77 epidemiologically unrelated strains from several countries and several ecological sources. The phylogenetic position of P. shigelloides within family Enterobacteriaceae was precisely defined by phylogenetic analysis of the same gene portions in other family members. Within P. shigelloides, high levels of nucleotide diversity (average percentage of nucleotide differences between strains, 1.49%) and genotypic diversity (64 distinct sequence types; Simpson's index, 99.7%) were found, with no salient internal phylogenetic structure. We estimated that homologous recombination in housekeeping genes affects P. shigelloides alleles and nucleotides 7 and 77 times more frequently than mutation, respectively. These ratios are similar to those observed in the naturally transformable species Streptococcus pneumoniae with a high rate of recombination. In contrast, recombination within Salmonella enterica, Escherichia coli, and Yersinia enterocolitica was much less frequent. P. shigelloides thus stands out among members of the Enterobacteriaceae. Its high rate of recombination results in a lack of association between genomic background and O and H antigenic factors, as observed for the 51 serotypes found in our sample. Given its robustness and discriminatory power, we recommend MLST as a reference method for population biology studies and epidemiological tracking of P. shigelloides strains.Plesiomonas shigelloides is a species of rod-shaped gramnegative bacteria recently classified in the family Enterobacteriaceae and is the only oxidase-positive member of this family (32). Freshwater and estuarine water are considered to be the natural environment of P. shigelloides (36), which is often isolated from fish and seafood (30,42). Like many Enterobacteriaceae species, P. shigelloides is also found in a wide range of hosts, including dogs,

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Conserved virulence of C to B capsule switched Neisseria meningitidis clinical isolates belonging to ET-37/ST-11 clonal complex

Cited by 47 publications

References 26 publications

Clonal Distribution of Disease-Associated and Healthy Carrier Isolates ofNeisseria meningitidisbetween 1983 and 2005 in Cuba

Clonal Distribution of Disease-Associated and Healthy Carrier Isolates ofNeisseria meningitidisbetween 1983 and 2005 in Cuba

Association of Meningococcal Phenotypes and Genotypes With Clinical Characteristics and Mortality of Meningitis in Children

Recombining Population Structure of Plesiomonas shigelloides ( Enterobacteriaceae ) Revealed by Multilocus Sequence Typing

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